New opportunities in immunotherapy in multiple myeloma
Abstract
Immunotherapy is a rapidly developing field of multiple myeloma, a disease which despite the development of new drugs remains incurable. There are several antigens that are being assessed in preclinical and clinical settings, but the most studied of all is B-cell maturation antigen (BCMA). BCMA is a target for antibody conjugated with toxins (ADCs), bispecific engagers (BITEs), and modified autologous lymphocytes (CAR-T, chimeric antigen receptor T cells). Belantamab mafodotin (ADC, registered in the European Union), teclistamab (BITE) and two CAR-Ts: ide-cel (Food and Drug Administation-approved) and cilta-cel are the most studied therapies in myeloma. Immunotherapy will definitely change the treatment strategy of multiple myeloma and accelerate the fight against myeloma.
Keywords: immunotherapyCAR-Tbispecific antibodies
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