open access

Vol 52, No 5 (2021)
Short communication
Submitted: 2021-07-16
Accepted: 2021-07-24
Published online: 2021-10-28
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Dysgranulopoiesis in patients with coronavirus disease 2019

Carolin Riemer1, Elisabeth Mack1, Andreas Burchert1, Margrit Gündisch2, Sarah Greib2, Rojin Etati1, Thomas Tarawneh1, Ihab Karim1, Christian Keller3, Harald Renz2, Chrysanthi Skevaki2, Andreas Neubauer1, Christian Michel1
Acta Haematol Pol 2021;52(5):516-521.
  1. Department of Hematology, Oncology, Immunology, Philipps-University Marburg, Baldingerstr., 35043 Marburg, Germany
  2. Institute of Laboratory Medicine, Universities of Giessen and Marburg Lung Center (UGMLC), Philips University Marburg, German Center for Lung Research (DZL)
  3. Institute of Virology, Philipps University Marburg and University Hospital Giessen and Marburg, Marburg, Germany

open access

Vol 52, No 5 (2021)
Submitted: 2021-07-16
Accepted: 2021-07-24
Published online: 2021-10-28


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Dysgranulopoiesis in patients with coronavirus disease 2019


Acta Haematologica Polonica


Vol 52, No 5 (2021)

Article type

Short communication



Published online


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Acta Haematol Pol 2021;52(5):516-521.


Carolin Riemer
Elisabeth Mack
Andreas Burchert
Margrit Gündisch
Sarah Greib
Rojin Etati
Thomas Tarawneh
Ihab Karim
Christian Keller
Harald Renz
Chrysanthi Skevaki
Andreas Neubauer
Christian Michel

References (15)
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  2. Zhu Na, Zhang D, Wang W, et al. China Novel Coronavirus Investigating and Research Team. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020; 382(8): 727–733.
  3. Terpos E, Ntanasis-Stathopoulos I, Elalamy I, et al. Hematological findings and complications of COVID-19. Am J Hematol. 2020; 95(7): 834–847.
  4. Jones JR, Ireland R. Morphological changes in a case of SARS-CoV-2 infection. Blood. 2020; 135(25): 2324.
  5. Lüke F, Orsó E, Kirsten J, et al. Coronavirus disease 2019 induces multi-lineage, morphologic changes in peripheral blood cells. EJHaem. 2020 [Epub ahead of print].
  6. Zini G, Bellesi S, Ramundo F, et al. Morphological anomalies of circulating blood cells in COVID-19. Am J Hematol. 2020; 95(7): 870–872.
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  8. Nazarullah A, Liang C, Villarreal A, et al. Peripheral blood examination findings in SARS-CoV-2 infection. Am J Clin Pathol. 2020; 154(3): 319–329.
  9. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020; 395(10223): 497–506.
  10. Wang D, Hu Bo, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020; 323(11): 1061–1069.
  11. Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020; 180(7): 934–943.
  12. Veras FP, Pontelli MC, Silva CM, et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology. J Exp Med. 2020; 217(12).
  13. Gustine JN, Jones D. Immunopathology of hyperinflammation in COVID-19. Am J Pathol. 2021; 191(1): 4–17.
  14. Berber I, Cagasar O, Sarici A, et al. Peripheral blood smear findings of COVID-19 patients provide information about the severity of the disease and the duration of hospital stay. Mediterr J Hematol Infect Dis. 2021; 13(1): e2021009.
  15. Lacy P. Mechanisms of degranulation in neutrophils. Allergy Asthma Clin Immunol. 2006; 2(3): 98–108.


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