Vol 53, No 1 (2022)
Original research article
Published online: 2022-02-25

open access

Page views 5137
Article views/downloads 352
Get Citation

Connect on Social Media

Connect on Social Media

Mean platelet volume and other hematological parameters in pediatric migraine

Yılmaz Akbaş1
Acta Haematol Pol 2022;53(1):53-57.


Introduction: According to our hypothesis, the mean platelet volume (MPV) value in migraine patients should be lower than in healthy individuals due to recurrent neuroinflammation during headache attacks. Therefore, this study aimed to identify differences between MPV and other hemogram parameters between pediatric patients with migraine and a healthy control group. Material and methods: This study included a total of 80 people, 40 patients and 40 control subjects. Those with hematological diseases, using alcohol or smoking, with malignancy, pregnancy, or with any chronic disease were excluded from the study. Results: Individuals in the control group were chosen to have the same age and same sex as the patient group (p = 0.98). The patient group had statistically significantly higher platelet counts than the control group (p = 0.043). MPV was lower in the patient group compared to the control group (p = 0.001), but platelet distribution width was higher in the patient group compared to the control group (p = 0.034) Conclusions: Migraine patients in the pediatric period were shown in our study to have low MPV values and elevated platelet counts due to recurrent neuroinflammation. This result shows that inflammation especially plays a vital role in migraine pathophysiology.

Article available in PDF format

View PDF Download PDF file


  1. Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018; 38(1): 1–211.
  2. Rasmussen BK. Epidemiology of headache. Cephalalgia. 2001; 21(7): 774–777.
  3. Ashina M, Hansen J, Do T, et al. Migraine and the trigeminovascular system — 40 years and counting. Lancet Neurol. 2019; 18(8): 795–804.
  4. Gasparyan AY, Ayvazyan L, Mikhailidis DP, et al. Mean platelet volume: a link between thrombosis and inflammation? Curr Pharm Des. 2011; 17(1): 47–58.
  5. Brzeźniakiewicz-Janus K, Lancé MD, Tukiendorf A, et al. Is migraine an MPV-related disease? An observational study of Polish neurological patients. Dis Markers. 2019; 2019: 9454580.
  6. Sarıcam G. Relationship between migraine headache and hematological parameters. Acta Neurol Belg. 2021; 121(4): 899–905.
  7. Poyrazoğlu HG, Öztürk AB. Predictive value of laboratory parameters in childhood migraine. Acta Neurol Belg. 2020; 120(4): 907–914.
  8. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol. 2001; 96(3): 776–781.
  9. Yüksel O, Helvaci K, Başar O, et al. An overlooked indicator of disease activity in ulcerative colitis: mean platelet volume. Platelets. 2009; 20(4): 277–281.
  10. Shen J, Ran ZH, Zhang Y, et al. Biomarkers of altered coagulation and fibrinolysis as measures of disease activity in active inflammatory bowel disease: a gender-stratified, cohort analysis. Thromb Res. 2009; 123(4): 604–611.
  11. Stamatelopoulos KS, Kitas GD, Papamichael CM, et al. Atherosclerosis in rheumatoid arthritis versus diabetes: a comparative study. Arterioscler Thromb Vasc Biol. 2009; 29(10): 1702–1708.
  12. Kisacik B, Tufan A, Kalyoncu U, et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008; 75(3): 291–294.
  13. Karabudak O, Ulusoy RE, Erikci AA, et al. Inflammation and hypercoagulable state in adult psoriatic men. Acta Derm Venereol. 2008; 88(4): 337–340.
  14. Makay B, Türkyilmaz Z, Unsal E. Mean platelet volume in children with familial Mediterranean fever. Clin Rheumatol. 2009; 28(8): 975–978.
  15. Ulusoy E. Use of MPV and MPV/PLT ratio in the differentiation of migraine and tension-type headache. Acta Haematol Pol. 2018; 49(1): 15–19.
  16. Kaushansky K. The molecular mechanisms that control thrombopoiesis. J Clin Invest. 2005; 115(12): 3339–3347.
  17. Butkiewicz AM, Kemona H, Dymicka-Piekarska V, et al. Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thromb Res. 2006; 118(2): 199–204.
  18. de Jager CPC, van Wijk PTL, Mathoera RB, et al. Lymphocytopenia and neutrophil-lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care. 2010; 14(5): R192.
  19. Lee SM, Russell A, Hellawell G. Predictive value of pretreatment inflammation-based prognostic scores (neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio) for invasive bladder carcinoma. Korean J Urol. 2015; 56(11): 749–755.
  20. Losada B, Guerra JA, Malón D, et al. Pretreatment neutrophil/lymphocyte, platelet/lymphocyte, lymphocyte/monocyte, and neutrophil/monocyte ratios and outcome in elderly breast cancer patients. Clin Transl Oncol. 2019; 21(7): 855–863.
  21. Marín Hernández C, Piñero Madrona A, Gil Vázquez PJ, et al. Usefulness of lymphocyte-to-monocyte, neutrophil-to-monocyte and neutrophil-to-lymphocyte ratios as prognostic markers in breast cancer patients treated with neoadjuvant chemotherapy. Clin Transl Oncol. 2018; 20(4): 476–483.
  22. Shi J, Zhao W, Ying H, et al. The relationship of platelet to lymphocyte ratio and neutrophil to monocyte ratio to radiographic grades of knee osteoarthritis. Z Rheumatol. 2018; 77(6): 533–537.