open access

Vol 52, No 3 (2021)
Original research article
Submitted: 2021-05-31
Accepted: 2021-05-31
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High mean platelet volume and neutrophil-to-lymphocyte ratio are predictors of mortality in patients with HIV-related non-Hodgkin’s lymphoma

Juan Camilo Salgado Sánchez1, Jorge Leonardo Gamboa Quiñones1, Oscar Mauricio Muñoz-Velandia12, Mónica Arévalo Zambrano23, José Roberto José Roberto Támara Ramírez124
DOI: 10.5603/AHP.2021.0037
·
Acta Haematol Pol 2021;52(3):195-201.
Affiliations
  1. Department of Internal Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia
  2. Hospital Universitario San Ignacio, Bogotá, Colombia
  3. Hematology Unit, Department of Internal Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia
  4. Infectology Unit, Department of Internal Medicine, Pontificia Universidad Javeriana, Bogotá, Colombia

open access

Vol 52, No 3 (2021)
ORIGINAL RESEARCH ARTICLE
Submitted: 2021-05-31
Accepted: 2021-05-31

Abstract

Introduction: Simple indices derived from a blood count are useful as predictors of survival in both solid and hematological tumors. However, these indices have not been studied in human immunodeficiency virus (HIV)-associated non-Hodgkin’s lymphoma (NHL). The present study evaluates whether there are differences in the survival of such patients at two years according to baseline values of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR). Material and methods: A retrospective cohort of patients between 2003 and 2018 with HIV and a confirmed diagnosis of some variant of nNHL at the Hospital Universitario San Ignacio, Bogotá, Colombia, was evaluated. 2-year survival was analyzed by comparing groups according to baseline values of MPV and NLR using Kaplan-Meier curves and log rank test. Cox regression model was used to control for confounding factors. Results: 31 patients were included. The combined follow-up time was 602 months. Ten patients died during follow-up. The 2-year survival was lower for patients with MPV > 7.5 fL (41.6 vs. 84.0%, p =0.01, log rank test: 0.0057) and NLR > 4.35 (33.0% vs. 76.0%, p =0.04; log rank test 0.028). Mortality was higher in patients with MPV > 7.5 fL (HR 6.39; confidence interval 95% 1.35–30.21, p =0.015) controlling by the effect of type of lymphoma, International Prognostic Index and functionality. Conclusion: High values of MPV and NLR at the time of diagnosis of NHL are associated with mortality in patients with HIV infection. It is necessary to evaluate the utility of including these markers in prognostic indices.

Abstract

Introduction: Simple indices derived from a blood count are useful as predictors of survival in both solid and hematological tumors. However, these indices have not been studied in human immunodeficiency virus (HIV)-associated non-Hodgkin’s lymphoma (NHL). The present study evaluates whether there are differences in the survival of such patients at two years according to baseline values of mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR). Material and methods: A retrospective cohort of patients between 2003 and 2018 with HIV and a confirmed diagnosis of some variant of nNHL at the Hospital Universitario San Ignacio, Bogotá, Colombia, was evaluated. 2-year survival was analyzed by comparing groups according to baseline values of MPV and NLR using Kaplan-Meier curves and log rank test. Cox regression model was used to control for confounding factors. Results: 31 patients were included. The combined follow-up time was 602 months. Ten patients died during follow-up. The 2-year survival was lower for patients with MPV > 7.5 fL (41.6 vs. 84.0%, p =0.01, log rank test: 0.0057) and NLR > 4.35 (33.0% vs. 76.0%, p =0.04; log rank test 0.028). Mortality was higher in patients with MPV > 7.5 fL (HR 6.39; confidence interval 95% 1.35–30.21, p =0.015) controlling by the effect of type of lymphoma, International Prognostic Index and functionality. Conclusion: High values of MPV and NLR at the time of diagnosis of NHL are associated with mortality in patients with HIV infection. It is necessary to evaluate the utility of including these markers in prognostic indices.

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Keywords

non-Hodgkin’s lymphoma, HIV, mean platelet volume, neutrophil-to-lymphocyte ratio

About this article
Title

High mean platelet volume and neutrophil-to-lymphocyte ratio are predictors of mortality in patients with HIV-related non-Hodgkin’s lymphoma

Journal

Acta Haematologica Polonica

Issue

Vol 52, No 3 (2021)

Article type

Original research article

Pages

195-201

DOI

10.5603/AHP.2021.0037

Bibliographic record

Acta Haematol Pol 2021;52(3):195-201.

Keywords

non-Hodgkin’s lymphoma
HIV
mean platelet volume
neutrophil-to-lymphocyte ratio

Authors

Juan Camilo Salgado Sánchez
Jorge Leonardo Gamboa Quiñones
Oscar Mauricio Muñoz-Velandia
Mónica Arévalo Zambrano
José Roberto José Roberto Támara Ramírez

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