open access

Vol 52, No 4 (2021)
Review article
Published online: 2021-08-31
Submitted: 2021-04-30
Accepted: 2021-05-12
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Optimal timing and conditioning regimen in allogeneic stem cell transplantation for AML

Christoph Schmid1
DOI: 10.5603/AHP.2021.0046
·
Acta Haematol Pol 2021;52(4):237-241.
Affiliations
  1. Department of Hematology and Oncology, Augsburg University Hospital and Medical Faculty, Augsburg, Germany

open access

Vol 52, No 4 (2021)
REVIEW ARTICLE
Published online: 2021-08-31
Submitted: 2021-04-30
Accepted: 2021-05-12

Abstract

In all stages of the disease, allogeneic stem cell transplantation (allo-SCT) plays an important role in the treatment of acute myeloid leukemia. It is an ongoing challenge to find the right balance between the chance of a cure and the risk of dying from side effects of the procedure. With respect to the conditioning, the large number of available protocols, ranging from non-myeloablative to a classical high-dose regimen, offers the opportunity to individualize the treatment, considering both the clinical situation and patient-specific factors such as age and co-morbidities. As a consequence, allo-SCT has become available to a larger percentage of patients, and the question as to whether or not to undergo a transplantation needs to be answered more frequently. The factors to be considered vary widely among patients in remission, those with relapsed disease, and those who never responded to conventional therapy. This review addresses this discussion, focusing on how to define an individualized and weighted treatment concept for each patient.

Abstract

In all stages of the disease, allogeneic stem cell transplantation (allo-SCT) plays an important role in the treatment of acute myeloid leukemia. It is an ongoing challenge to find the right balance between the chance of a cure and the risk of dying from side effects of the procedure. With respect to the conditioning, the large number of available protocols, ranging from non-myeloablative to a classical high-dose regimen, offers the opportunity to individualize the treatment, considering both the clinical situation and patient-specific factors such as age and co-morbidities. As a consequence, allo-SCT has become available to a larger percentage of patients, and the question as to whether or not to undergo a transplantation needs to be answered more frequently. The factors to be considered vary widely among patients in remission, those with relapsed disease, and those who never responded to conventional therapy. This review addresses this discussion, focusing on how to define an individualized and weighted treatment concept for each patient.

Get Citation

Keywords

AML, allogeneic transplantation, timing, conditioning

About this article
Title

Optimal timing and conditioning regimen in allogeneic stem cell transplantation for AML

Journal

Acta Haematologica Polonica

Issue

Vol 52, No 4 (2021)

Article type

Review article

Pages

237-241

Published online

2021-08-31

DOI

10.5603/AHP.2021.0046

Bibliographic record

Acta Haematol Pol 2021;52(4):237-241.

Keywords

AML
allogeneic transplantation
timing
conditioning

Authors

Christoph Schmid

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