open access

Vol 27, No 4 (2021)
Research paper
Published online: 2022-01-28
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New predictors of atherosclerosis progression after surgical interventions on the arteries of the lower extremities

DOI: 10.5603/AA.2021.0015
·
Acta Angiologica 2021;27(4):130-137.
Affiliations
  1. Ryazan State Medical University, 390026 Vysokovoltnaya str. 9, Ryazan, Russia, 390026 Рязань, Russian Federation

open access

Vol 27, No 4 (2021)
-- For assignment --
Published online: 2022-01-28

Abstract

BACKGROUNDː Thanks to experiments on animals, the influence of biomarkers of apoptosis, proliferation and endothelial dysfunction on the pathogenesis of atherosclerosis was proved. Aim: to identify the effect of these biomarkers on the progression of atherosclerosis in patients with peripheral arterial disease after surgery. METHODSː Patients were divided into two groups: A - 40 patients who have undergone endovascular interventions, B -38 patients, who have undergone hybrid surgery on the arteries of the lower extremities. Biomarkers Bax, sFas, PDGF BB, and nitric oxide (NO) were studied before intervention, on the 1st, 7th, 30th day after the operation. RESULTSː When comparing initial values of indicators and their values in the dynamics, the difference between group A and B was not found (p > 0.05). Nine patients of group В developed progression of atherosclerosis after 17 months. Roc analysis showed that initial sFas ≤ 0,92 ng / ml, initial Вах ≥ 25,3 ng / ml, NO values ≤128.4 mmol / ml, sFas ≤ 0.645 ng / ml, Вах ≥ 33,8 ng / ml on the first postoperative day, and PDGF BB amount on the 7th day ≥ 28 ng / ml is associated with progression of atherosclerosis. CONCLUSIONSː The dynamics of biomarkers of apoptosis, proliferation and endothelium dysfunction in patients after endovascular and hybrid interventions did not differ significantly. The activation of two pathways markers of apoptosis against the background of reduced synthesis of NO leads to an enhanced proliferative response and is associated with progression of atherosclerosis after surgery.

Abstract

BACKGROUNDː Thanks to experiments on animals, the influence of biomarkers of apoptosis, proliferation and endothelial dysfunction on the pathogenesis of atherosclerosis was proved. Aim: to identify the effect of these biomarkers on the progression of atherosclerosis in patients with peripheral arterial disease after surgery. METHODSː Patients were divided into two groups: A - 40 patients who have undergone endovascular interventions, B -38 patients, who have undergone hybrid surgery on the arteries of the lower extremities. Biomarkers Bax, sFas, PDGF BB, and nitric oxide (NO) were studied before intervention, on the 1st, 7th, 30th day after the operation. RESULTSː When comparing initial values of indicators and their values in the dynamics, the difference between group A and B was not found (p > 0.05). Nine patients of group В developed progression of atherosclerosis after 17 months. Roc analysis showed that initial sFas ≤ 0,92 ng / ml, initial Вах ≥ 25,3 ng / ml, NO values ≤128.4 mmol / ml, sFas ≤ 0.645 ng / ml, Вах ≥ 33,8 ng / ml on the first postoperative day, and PDGF BB amount on the 7th day ≥ 28 ng / ml is associated with progression of atherosclerosis. CONCLUSIONSː The dynamics of biomarkers of apoptosis, proliferation and endothelium dysfunction in patients after endovascular and hybrid interventions did not differ significantly. The activation of two pathways markers of apoptosis against the background of reduced synthesis of NO leads to an enhanced proliferative response and is associated with progression of atherosclerosis after surgery.

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Keywords

apoptosis, cell proliferation, endothelial dysfunction, atherosclerosis progression, endovascular interventions, hybrid interventions.

About this article
Title

New predictors of atherosclerosis progression after surgical interventions on the arteries of the lower extremities

Journal

Acta Angiologica

Issue

Vol 27, No 4 (2021)

Article type

Research paper

Pages

130-137

Published online

2022-01-28

Page views

1038

Article views/downloads

91

DOI

10.5603/AA.2021.0015

Bibliographic record

Acta Angiologica 2021;27(4):130-137.

Keywords

apoptosis
cell proliferation
endothelial dysfunction
atherosclerosis progression
endovascular interventions
hybrid interventions.

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