Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 as a diagnostic marker for acute ST-elevation myocardial infarction
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Abstract
Background: ST-elevation myocardial infarction (STEMI) is a major cause of mortality and morbidity worldwide, but fast and reliable diagnosis can reduce mortality. Therefore, this study aimed to assess the diagnostic value of serum soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1) among patients with acute STEMI, and also its importance to monitor the response to percutaneous coronary intervention (PCI). A total of 30 healthy subjects and 150 acute STEMI patients treated by PCI were enrolled into our study. Beside the routine lab work; serum sLOX-1 level was measured using commercial ELISA kit. Results: Our results revealed that the increased serum sLOX-1 level among patients with acute STEMI (112.79±10.76) than controls (47.75±12.87). After the treatment of acute STEMI patients with the primary PCI, the level of serum sLOX-1 was nonsigificantly decreased either after 12hrs (111.04±11.06) or 48hrs (110.31±11.24) from PCI management. Our results also showed that serum sLOX-1 level was positively correlated with cholesterol, LDL, troponin I, CK-MB, CRP, TG and VLDL. Results obtained from ROC curve analysis showed that serum sLOX-1 is an excellent biomarker for acute STEMI disease, its AUC is one with 100% sensitivity and specificity. Conclusions: Finally, from these results we can conclude that LOX-1 has a crucial role in the pathogenesis of acute STEMI; also, serum sLOX-1 could be a good diagnostic clinical biomarker for the detection of acute STEMI disease and to monitor the response to PCI.
Keywords: Acute coronary syndrome (ACS)coronary heart diseaselectin-like oxidized low-density lipoprotein receptor-1 (LOX-1)percutaneous coronary intervention (PCI)myocardial infarction (MI)ST-elevation myocardial infarction (STEMI).
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