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Vol 27, No 2 (2021)
Research paper
Published online: 2021-10-15

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Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report

Marek Iłżecki1, Marcin Feldo1, Anna Bogucka-Kocka2, Daniel Zalewski2, Paulina Chmiel2, Shavn Dave3, Joanna Iłżecka4
Acta Angiologica 2021;27(2):49-52.

Abstract

Background: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to evaluate changes in serum levels of the oxidative stress marker peroxiredoxin-1 (PRDX1) in patients undergoing CEA. Material and methods: Twenty-four patients undergoing endarterectomy for critical stenosis of the internal carotid artery participated in the study. Blood for testing was collected before CEA and twice after surgery. PRDX1 was determined by ELISA. Results: The timing of blood sampling did not affect PRDX1 levels (p > 0.05). There was no statistically significant difference in serum PRDX1 levels between male and female groups and depending on the age of the patients (p > 0.05). Conclusion: PRDX1 cannot be considered as a marker of neurological complications after CEA.

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