open access

Vol 27, No 2 (2021)
Research paper
Published online: 2021-10-15
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Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report

Marek Iłżecki1, Marcin Feldo1, Anna Bogucka-Kocka2, Daniel Zalewski2, Paulina Chmiel2, Shavn Dave3, Joanna Iłżecka4
DOI: 10.5603/AA.2021.0009
·
Acta Angiologica 2021;27(2):49-52.
Affiliations
  1. Chair and Department of Vascular Surgery and Angiology, Medical University of Lublin, Poland, Staszica 11, 20-081 Lublin, Poland
  2. Chair and Department of Biology and Genetics, Medical University of Lublin, Poland, Lublin, Poland
  3. University of Oklahoma Health Sciences Center in Oklahoma City, Oklahoma, USA, Oklahoma City, United States
  4. Independent Neurological Rehabilitation Unit, Medical University of Lublin, Poland, Poland

open access

Vol 27, No 2 (2021)
Original papers
Published online: 2021-10-15

Abstract

Background: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to evaluate changes in serum levels of the oxidative stress marker peroxiredoxin-1 (PRDX1) in patients undergoing CEA. Material and methods: Twenty-four patients undergoing endarterectomy for critical stenosis of the internal carotid artery participated in the study. Blood for testing was collected before CEA and twice after surgery. PRDX1 was determined by ELISA. Results: The timing of blood sampling did not affect PRDX1 levels (p > 0.05). There was no statistically significant difference in serum PRDX1 levels between male and female groups and depending on the age of the patients (p > 0.05). Conclusion: PRDX1 cannot be considered as a marker of neurological complications after CEA.

Abstract

Background: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to evaluate changes in serum levels of the oxidative stress marker peroxiredoxin-1 (PRDX1) in patients undergoing CEA. Material and methods: Twenty-four patients undergoing endarterectomy for critical stenosis of the internal carotid artery participated in the study. Blood for testing was collected before CEA and twice after surgery. PRDX1 was determined by ELISA. Results: The timing of blood sampling did not affect PRDX1 levels (p > 0.05). There was no statistically significant difference in serum PRDX1 levels between male and female groups and depending on the age of the patients (p > 0.05). Conclusion: PRDX1 cannot be considered as a marker of neurological complications after CEA.

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Keywords

brain ischemia-reperfusion injury, carotid endarterectomy, peroxiredoxin-1

About this article
Title

Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report

Journal

Acta Angiologica

Issue

Vol 27, No 2 (2021)

Article type

Research paper

Pages

49-52

Published online

2021-10-15

DOI

10.5603/AA.2021.0009

Bibliographic record

Acta Angiologica 2021;27(2):49-52.

Keywords

brain ischemia-reperfusion injury
carotid endarterectomy
peroxiredoxin-1

Authors

Marek Iłżecki
Marcin Feldo
Anna Bogucka-Kocka
Daniel Zalewski
Paulina Chmiel
Shavn Dave
Joanna Iłżecka

References (17)
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