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Vol 27, No 2 (2021)
Research paper
Published online: 2021-10-15

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Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report

Marek Iłżecki1, Marcin Feldo1, Anna Bogucka-Kocka2, Daniel Zalewski2, Paulina Chmiel2, Shavn Dave3, Joanna Iłżecka4
Acta Angiologica 2021;27(2):49-52.


Background: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to evaluate changes in serum levels of the oxidative stress marker peroxiredoxin-1 (PRDX1) in patients undergoing CEA. Material and methods: Twenty-four patients undergoing endarterectomy for critical stenosis of the internal carotid artery participated in the study. Blood for testing was collected before CEA and twice after surgery. PRDX1 was determined by ELISA. Results: The timing of blood sampling did not affect PRDX1 levels (p > 0.05). There was no statistically significant difference in serum PRDX1 levels between male and female groups and depending on the age of the patients (p > 0.05). Conclusion: PRDX1 cannot be considered as a marker of neurological complications after CEA.

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  1. Campbell B, Khatri P. Stroke. The Lancet. 2020; 396(10244): 129–142.
  2. Campbell BCV, De Silva DA, Macleod MR, et al. Ischaemic stroke. Nat Rev Dis Primers. 2019; 5(1): 70.
  3. Orrapin S, Rerkasem K. Carotid endarterectomy for symptomatic carotid stenosis. Cochrane Database Syst Rev. 2017; 6: CD001081.
  4. Pasin L, Marrocco Trischitta MM, Landoni G, et al. Operative morbidity and mortality in octogenarians after carotid endarterectomy: a propensity score matching study. J Cardiovasc Surg (Torino). 2019; 60(6): 703–707.
  5. Lieb M, Shah U, Hines GL. Cerebral hyperperfusion syndrome after carotid intervention: a review. Cardiol Rev. 2012; 20(2): 84–89.
  6. Sundefeld Tardini DM, Bonetti Yoshida W. Brain injury due ischemia and reperfusion in carotid endarterectomy surgery. Rev Port Cir Cardiotorac Vasc. 2003; 10(3): 133–140.
  7. Zhu H, Santo A, Li Y. The antioxidant enzyme peroxiredoxin and its protective role in neurological disorders. Exp Biol Med (Maywood). 2012; 237(2): 143–149.
  8. Park MiH, Jo M, Kim YuRi, et al. Roles of peroxiredoxins in cancer, neurodegenerative diseases and inflammatory diseases. Pharmacol Ther. 2016; 163: 1–23.
  9. Garcia-Bonilla L, Iadecola C. Peroxiredoxin sets the brain on fire after stroke. Nat Med. 2012; 18(6): 858–859.
  10. Kunze A, Zierath D, Tanzi P, et al. Peroxiredoxin 5 (PRX5) is correlated inversely to systemic markers of inflammation in acute stroke. Stroke. 2014; 45(2): 608–610.
  11. Pascot R, Parat B, Le Teurnier Y, et al. Predictive Factors of Silent Brain Infarcts after Asymptomatic Carotid Endarterectomy. Ann Vasc Surg. 2018; 51: 225–233.
  12. Rots ML, Meershoek AJA, Bonati LH, et al. Editor's Choice - Predictors of New Ischaemic Brain Lesions on Diffusion Weighted Imaging After Carotid Stenting and Endarterectomy: A Systematic Review. Eur J Vasc Endovasc Surg. 2019; 58(2): 163–174.
  13. Shichita T, Hasegawa E, Kimura A, et al. Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med. 2012; 18(6): 911–917.
  14. Brea D, Rodríguez-González R, Sobrino T, et al. Proteomic analysis shows differential protein expression in endothelial progenitor cells between healthy subjects and ischemic stroke patients. Neurol Res. 2011; 33(10): 1057–1063.
  15. Liu Q, Zhang Y. PRDX1 enhances cerebral ischemia-reperfusion injury through activation of TLR4-regulated inflammation and apoptosis. Biochem Biophys Res Commun. 2019; 519(3): 453–461.
  16. Tao RR, Wang H, Hong LJ, et al. Nitrosative stress induces peroxiredoxin 1 ubiquitination during ischemic insult via E6AP activation in endothelial cells both in vitro and in vivo. Antioxid Redox Signal. 2014; 21(1): 1–16.
  17. Richard S, Lapierre V, Girerd N, et al. Diagnostic performance of peroxiredoxin 1 to determine time-of-onset of acute cerebral infarction. Sci Rep. 2016; 6: 38300.