Serum peroxiredoxin-1 in patients undergoing carotid endarterectomy – short report
, 1, 2, 2, 2, 3, 4
Abstract
Background: Endarterectomy of the internal carotid artery (CEA) plays an important role in the prevention of cerebral ischemic stroke; however, this surgical procedure may cause neurological complications. The aim of this study was to evaluate changes in serum levels of the oxidative stress marker peroxiredoxin-1 (PRDX1) in patients undergoing CEA. Material and methods: Twenty-four patients undergoing endarterectomy for critical stenosis of the internal carotid artery participated in the study. Blood for testing was collected before CEA and twice after surgery. PRDX1 was determined by ELISA. Results: The timing of blood sampling did not affect PRDX1 levels (p > 0.05). There was no statistically significant difference in serum PRDX1 levels between male and female groups and depending on the age of the patients (p > 0.05). Conclusion: PRDX1 cannot be considered as a marker of neurological complications after CEA.
Keywords: brain ischemia-reperfusion injurycarotid endarterectomyperoxiredoxin-1
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