open access

Vol 28, No 1 (2022)
Research paper
Published online: 2022-05-02
Get Citation

Evaluation of the Predictive Role of Standard Laboratory Tests for Disease Severity in Patients with Deep Venous Thrombosis

Mustafa Etli1, Oguz Karahan1, Faruk Serhatlıoglu2, Hakan Ontas3
DOI: 10.5603/AA.2022.0001
·
Acta Angiologica 2022;28(1):16-21.
Affiliations
  1. Medical School of Alaaddin Keykubat University, Department of Cardiovascular Surgery, Oba mah. Fidanlık cad Alanya, 07400 Antalya, Turkey
  2. Medical School of Omer Halis Demir University, Department of Cardiovascular Surgery, Nigde, Turkey
  3. Balıkesir Atatürk City Hospital, Department of Cardiovascular Surgery, Balıkesir, Turkey

open access

Vol 28, No 1 (2022)
Original papers
Published online: 2022-05-02

Abstract

Introduction: Deep venous thrombosis (DVT) can result in fatal outcomes if it is not timely diagnosed and sufficiently treated. Some laboratory markers were identified in previous reports for predicting the disease with low sensitivity or specificity. We aimed to evaluate the predictive value of serum albumin levels and compare them with conventional laboratory parameters. Material and Methods: Fifty patients with acute lower-extremity DVT who has no previous history of malignancy or hematologic disorder were included in the study. The demographical variables and standard biomarkers of the DVT group were compared with the normal population (n:50). Thereafter patients were divided into two groups as extensive DVT (thrombosis involves popliteal, femoral, and iliac veins together) and localized DVT (thrombosis involves popliteal vein and below) and biomarkers were compared in patient groups. Results: The demographical variables and white blood cell count (WBC) found as similar between healthy groups and DVT groups. However, mean platelet volume (MPV), D-Dimer, neutrophil to lymphocyte ratio (NLR), and fibrinogen to albumin ratio (FAR) were found markedly higher in DVT patients. Moreover, statistically incremental FAR and NLR levels were detected (p < 0.05) in patients with extensive DVT (involved iliac and femoral veins). Conclusion: Serum NLR and FAR levels seem to be significant predictors for the extensive thrombotic event in patients with DVT.

Abstract

Introduction: Deep venous thrombosis (DVT) can result in fatal outcomes if it is not timely diagnosed and sufficiently treated. Some laboratory markers were identified in previous reports for predicting the disease with low sensitivity or specificity. We aimed to evaluate the predictive value of serum albumin levels and compare them with conventional laboratory parameters. Material and Methods: Fifty patients with acute lower-extremity DVT who has no previous history of malignancy or hematologic disorder were included in the study. The demographical variables and standard biomarkers of the DVT group were compared with the normal population (n:50). Thereafter patients were divided into two groups as extensive DVT (thrombosis involves popliteal, femoral, and iliac veins together) and localized DVT (thrombosis involves popliteal vein and below) and biomarkers were compared in patient groups. Results: The demographical variables and white blood cell count (WBC) found as similar between healthy groups and DVT groups. However, mean platelet volume (MPV), D-Dimer, neutrophil to lymphocyte ratio (NLR), and fibrinogen to albumin ratio (FAR) were found markedly higher in DVT patients. Moreover, statistically incremental FAR and NLR levels were detected (p < 0.05) in patients with extensive DVT (involved iliac and femoral veins). Conclusion: Serum NLR and FAR levels seem to be significant predictors for the extensive thrombotic event in patients with DVT.

Get Citation

Keywords

Deep venous thrombosis; extensive disease; neutrophil to lymphocyte ratio; fibrinogen to albumin ratio

About this article
Title

Evaluation of the Predictive Role of Standard Laboratory Tests for Disease Severity in Patients with Deep Venous Thrombosis

Journal

Acta Angiologica

Issue

Vol 28, No 1 (2022)

Article type

Research paper

Pages

16-21

Published online

2022-05-02

Page views

170

Article views/downloads

26

DOI

10.5603/AA.2022.0001

Bibliographic record

Acta Angiologica 2022;28(1):16-21.

Keywords

Deep venous thrombosis
extensive disease
neutrophil to lymphocyte ratio
fibrinogen to albumin ratio

Authors

Mustafa Etli
Oguz Karahan
Faruk Serhatlıoglu
Hakan Ontas

References (19)
  1. Thachil J. Deep vein thrombosis. Hematology. 2014; 19(5): 309–310.
  2. Baglin T. Using the laboratory to predict recurrent venous thrombosis. Int J Lab Hematol. 2011; 33(4): 333–342.
  3. Riddle DL, Hillner BE, Wells PS, et al. Diagnosis of lower-extremity deep vein thrombosis in outpatients with musculoskeletal disorders: a national survey study of physical therapists. Phys Ther. 2004; 84(8): 717–728.
  4. Rabinovich A, Cohen JM, Cushman M, et al. Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome. J Thromb Haemost. 2015; 13(3): 398–408.
  5. Aydın U. Is low serum albumin level a risk factor for deep venous thrombosis in temporary hemodialysis catheter inserted patients? Turkish Journal of Thoracic and Cardiovascular Surgery. 2013; 21(4): 955–958.
  6. Rezende SM, Lijfering WM, Rosendaal FR, et al. Hematologic variables and venous thrombosis: red cell distribution width and blood monocyte count are associated with an increased risk. Haematologica. 2014; 99(1): 194–200.
  7. Byrnes JR, Wolberg AS, Walton BL, et al. Fibrinogen and red blood cells in venous thrombosis. Thromb Res. 2014; 133 Suppl 1(16): S38–S40.
  8. Wakefield TW, Strieter RW, Schaub R. Venous thrombosis prophylaxis by inflammatory inhibition without anticoagulation therapy. J Vasc Surg. 2000; 31(2): 309–324.
  9. Gulcan M, Varol E, Etli M, et al. Mean platelet volume is increased in patients with deep vein thrombosis. Clin Appl Thromb Hemost. 2012; 18(4): 427–430.
  10. Lai HM, Xu R, Yang YN, et al. Association of mean platelet volume with angiographic thrombus burden and short-term mortality in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Catheter Cardiovasc Interv. 2015; 85 Suppl 1: 724–733.
  11. Tanboga IH, Topcu S, Aksakal E, et al. Determinants of angiographic thrombus burden in patients with ST-segment elevation myocardial infarction. Clin Appl Thromb Hemost. 2014; 20(7): 716–722.
  12. Erkol A, Oduncu V, Turan B, et al. Neutrophil to lymphocyte ratio in acute ST-segment elevation myocardial infarction. Am J Med Sci. 2014; 348(1): 37–42.
  13. Barker T, Rogers VE, Henriksen VT, et al. Is there a link between the neutrophil-to-lymphocyte ratio and venous thromboembolic events after knee arthroplasty? A pilot study. J Orthop Traumatol. 2016; 17(2): 163–168.
  14. Canan A, Halıcioğlu SS, Gürel S. Mean platelet volume and D-dimer in patients with suspected deep venous thrombosis. J Thromb Thrombolysis. 2012; 34(2): 283–287.
  15. Klovaite J, Nordestgaard BG, Tybjærg-Hansen A, et al. Elevated fibrinogen levels are associated with risk of pulmonary embolism, but not with deep venous thrombosis. Am J Respir Crit Care Med. 2013; 187(3): 286–293.
  16. Joven J, Clivillé X, Camps J, et al. Plasma protein abnormalities in nephrotic syndrome: effect on plasma colloid osmotic pressure and viscosity. Clin Chem. 1997; 43(7): 1223–1231.
  17. Folsom AR, Lutsey PL, Heckbert SR, et al. Serum albumin and risk of venous thromboembolism. Thromb Haemost. 2010; 104(1): 100–104.
  18. Sapmaz I, Saba T, Haberal C, et al. Fibrinogen- Albumin Ratio: An Intriguing Relationship for Assessing Trombosis Risk and Suspicious Effect on Blood viscosity. International Cardiovascular Research Journal. 2011; 5(4): 153–154.
  19. Karahan O, Yavuz C, Kankilic N, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagul Fibrinolysis. 2016; 27(6): 684–690.

Regulations

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

By "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail: viamedica@viamedica.pl