English Polski
Vol 27, No 2 (2021)
Review paper
Published online: 2021-10-15

open access

Page views 6677
Article views/downloads 669
Get Citation

Connect on Social Media

Connect on Social Media

Head and neck lymphedema (HNL) – a review paper.

Karolina Dorobisz1, Andrzej Szuba2, Tomasz Zatoński1
Acta Angiologica 2021;27(2):53-56.

Abstract

Lymphedema is a common condition of tissue swelling and fluid retention. Due to improper tissue drainage and is a sign of lymphatic system dysfunction. It may occur on the trunk, limbs and in the head and neck region - head and neck cancer. Head and neck lymphedema is a common complication of ENT procedures. The research reveals that up to 50% of patients with head and neck cancer develop head and neck lymphedema. The lack of appropriate diagnostics and treatment of lymphedema lead to serious complications, longer hospitalization and much higher costs of treatment. Head and neck lympedema significantly increases the level of frustration in patients, especially those with cancer who experience greater stress and anxiety as a result of uncertain prognosis. Therefore, it is advisable to broaden the research on HNL diagnosis and treatment. This review presents symptoms, current diagnosis strategies, treatment and recommendations in head and neck lymphedema.

Article available in PDF format

View PDF Download PDF file

References

  1. Foldi M, Foldi E. Lymphostatic diseases. In: Strossenruther RH, Kubic S. ed. Foldi’s textbook of lymphology for physicians and lymphedema therapists. Urban and Fischer, Munich 2006: 224–240.
  2. Miaskowski C, Dodd M, Paul SM, et al. Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. PLoS One. 2013; 8(4): e60164.
  3. Deng J, Ridner SH, Dietrich MS, et al. Factors associated with external and internal lymphedema in patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2012; 84(3): e319–e328.
  4. Taylor M, Hoerauf A, Bockarie M. Lymphatic filariasis and onchocerciasis. The Lancet. 2010; 376(9747): 1175–1185.
  5. DiSipio T, Rye S, Newman B, et al. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol. 2013; 14(6): 500–515.
  6. Miaskowski C, Dodd M, Paul SM, et al. Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. PLoS One. 2013; 8(4): e60164.
  7. Newman B, Lose F, Kedda MA, et al. Possible genetic predisposition to lymphedema after breast cancer. Lymphat Res Biol. 2012; 10(1): 2–13.
  8. Wolff HA, Overbeck T, Roedel RM, et al. Toxicity of daily low dose cisplatin in radiochemotherapy for locally advanced head and neck cancer. J Cancer Res Clin Oncol. 2009; 135(7): 961–967.
  9. Tribius S, Kronemann S, Kilic Y, et al. Radiochemotherapy including cisplatin alone versus cisplatin + 5-fluorouracil for locally advanced unresectable stage IV squamous cell carcinoma of the head and neck. Strahlenther Onkol. 2009; 185(10): 675–681.
  10. Smith BG, Lewin JS. Lymphedema management in head and neck cancer. Curr Opin Otolaryngol Head Neck Surg. 2010; 18(3): 153–158.
  11. Büntzel J, Glatzel M, Mücke R, et al. Influence of amifostine on late radiation-toxicity in head and neck cancer--a follow-up study. Anticancer Res. 2007; 27(4A): 1953–1956.
  12. Dietz A, Rudat V, Nollert J, et al. [Chronic laryngeal edema as a late reaction to radiochemotherapy]. HNO. 1998; 46(8): 731–738.
  13. Büntzel J, Glatzel M, Mücke R, et al. Amifostine in simultaneous radiochemotherapy of advanced head and neck cancer. Semin Radiat Oncol. 2002; 12(1 Suppl 1): 4–13.
  14. Schiefke F, Akdemir M, Weber A, et al. Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection. Head Neck. 2009; 31(4): 503–512.
  15. Deng J, Ridner SH, Dietrich MS, et al. Prevalence of secondary lymphedema in patients with head and neck cancer. J Pain Symptom Manage. 2012; 43(2): 244–252.
  16. Withey S, Pracy P, Vaz F, et al. Sensory deprivation as a consequence of severe head and neck lymphoedema. J Laryngol Otol. 2001; 115(1): 62–64.
  17. Piso DU, Eckardt A, Liebermann A, et al. Early rehabilitation of head-neck edema after curative surgery for orofacial tumors. Am J Phys Med Rehabil. 2001; 80(4): 261–269.
  18. Murphy BA, Gilbert J. Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae, and rehabilitation. Semin Radiat Oncol. 2009; 19(1): 35–42.
  19. Honnor A. Understanding the management of lymphoedema for patients with advanced disease. Int J Palliat Nurs. 2009; 15(4): 162, 164, 166–9.
  20. Penner JL. Psychosocial care of patients with head and neck cancer. Semin Oncol Nurs. 2009; 25(3): 231–241.
  21. Tschiesner U, Linseisen E, Baumann S, et al. Assessment of functioning in patients with head and neck cancer according to the International Classification of Functioning, Disability, and Health (ICF): a multicenter study. Laryngoscope. 2009; 119(5): 915–923.
  22. Smith B, Lewin J. Lymphedema management in head and neck cancer. Current Opinion in Otolaryngology & Head & Neck Surgery. 2010; 18(3): 153–158.
  23. Chikly BJ. Manual techniques addressing the lymphatic system: origins and development. J Am Osteopath Assoc. 2005; 105(10): 457–464.
  24. Micke O, Schomburg L, Buentzel J, et al. Selenium in oncology: from chemistry to clinics. Molecules. 2009; 14(10): 3975–3988.
  25. Hammerl B, Döller W. [Secondary malignant lymphedema in head and neck tumors]. Wien Med Wochenschr. 2008; 158(23-24): 695–701.
  26. Taylor SM, Brake M. Liposuction for the management of submental lymphedema in the head and neck cancer patient. Otolaryngol Head Neck Surg. 2012; 146(6): 1028–1030.
  27. Mihara M, Uchida G, Hara H, et al. Lymphaticovenous anastomosis for facial lymphoedema after multiple courses of therapy for head-and-neck cancer. J Plast Reconstr Aesthet Surg. 2011; 64(9): 1221–1225.
  28. Shaitelman S, Cromwell K, Rasmussen J, et al. Recent progress in the treatment and prevention of cancer-related lymphedema. CA: A Cancer Journal for Clinicians. 2014; 65(1): 55–81.
  29. Smith BG, Hutcheson KA, Little LG, et al. Lymphedema outcomes in patients with head and neck cancer. Otolaryngol Head Neck Surg. 2015; 152(2): 284–291.
  30. Szolnoky G, Szendi-Horváth K, Seres L, et al. Manual lymph drainage efficiently reduces postoperative facial swelling and discomfort after removal of impacted third molars. Lymphology. 2007; 40(3): 138–142.
  31. McGarvey AC, Osmotherly PG, Hoffman GR, et al. Lymphoedema following treatment for head and neck cancer: impact on patients, and beliefs of health professionals. Eur J Cancer Care (Engl). 2014; 23(3): 317–327.
  32. Shih YCT, Xu Y, Cormier JN, et al. Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study. J Clin Oncol. 2009; 27(12): 2007–2014.
  33. Blome C, Augustin M, Heyer K, et al. Evaluation of patient-relevant outcomes of lymphedema and lipedema treatment: development and validation of a new benefit tool. Eur J Vasc Endovasc Surg. 2014; 47(1): 100–107.
  34. Cheville AL, Almoza M, Courmier JN, et al. A prospective cohort study defining utilities using time trade-offs and the Euroqol-5D to assess the impact of cancer-related lymphedema. Cancer. 2010; 116(15): 3722–3731.
  35. Greenslade MV, House CJ. Living with lymphedema: a qualitative study of women's perspectives on prevention and management following breast cancer-related treatment. Can Oncol Nurs J. 2006; 16(3): 165–179.