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Vol 26, No 2 (2020)
Review paper
Published online: 2020-09-25

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Management of isolated distal deep vein thrombosis. A persistent conundrum?

Nalaka Gunawansa1, Thilina Gunawardena1
Acta Angiologica 2020;26(2):65-71.


Isolated distal deep vein thrombosis (IDDVT) accounts for approximately 50% of all patients diagnosed with
DVT. While the definitive management of patients with proximal deep vein thrombosis is fairly well defined,
IDDVT remains shrouded uncertainty. The great majority of patients with IDDVT may remain with little or no
symptoms and have spontaneous resolution of the thrombi. However, a small but significant fraction may show
proximal thrombus extension and may proceed to cause pulmonary embolism or late deep venous reflux.
Identification of this subgroup of patients with IDDVT who have a greater propensity for thrombus extension or
further sequelae remains the cornerstone of individualized management for optimal results.

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