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Investigation of clinical and genetic factors in patients with deep vein thrombosis. A retrospective study
, 2, 2
Affiliations- bozok university, Department of Medical Biology, Faculty of Medicine, Bozok University,, 66100 YOZGAT, Türkiye
- Department of Cardiovascular Surgery, Faculty of Medicine, Yozgat Bozok University, Yozgat, TURKEY
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Abstract
Introduction: Generally, risk factors for deep vein thrombosis (DVT) include advanced age, surgery, fractures,
pregnancy, puerperium, use of oral contraceptives, hormone replacement therapy, cancer and genetics
associated with the hemostatic system in influencing thrombotic risk. The aim of this study was to evaluate
routine complete blood count parameters, the clinical and genetic data of patients with diagnosis of DVT in
our hospital and to contribute to the literature with our results.
Material and methods: This retrospective study included a total of 152 patients (67 males and 85 females)
diagnosed with DVT between January 2016 and September 2019. The history, clinical findings, venous doppler
ultrasonography and genetic analysis results of patients were evaluated.
Results: The study included 152 DVT patients. When the lower extremity venous doppler ultrasonography
(VDU) results were evaluated, venous insufficiency was detected in 126 patients (82.9%), 57 of whom were
male and 69 were female. Genetic results of F2 G20210A, FVL G1691A, MTHFR C677T and MTHFR A1298C
were examined. FLV gene distributions were statistically different between genders (38.8% of men; 16.5% of
women). This difference was also statistically significant (p = 0.003).
Conclusion: The hemogram parameters were found to be insufficient markers. VDU was seen to be a clinically
necessary marker in diagnosis; and genetic outcomes were important in initiating appropriate treatment in the
early period. These results also show that there are differences according to gender in determining thrombotic risk.
Abstract
Introduction: Generally, risk factors for deep vein thrombosis (DVT) include advanced age, surgery, fractures,
pregnancy, puerperium, use of oral contraceptives, hormone replacement therapy, cancer and genetics
associated with the hemostatic system in influencing thrombotic risk. The aim of this study was to evaluate
routine complete blood count parameters, the clinical and genetic data of patients with diagnosis of DVT in
our hospital and to contribute to the literature with our results.
Material and methods: This retrospective study included a total of 152 patients (67 males and 85 females)
diagnosed with DVT between January 2016 and September 2019. The history, clinical findings, venous doppler
ultrasonography and genetic analysis results of patients were evaluated.
Results: The study included 152 DVT patients. When the lower extremity venous doppler ultrasonography
(VDU) results were evaluated, venous insufficiency was detected in 126 patients (82.9%), 57 of whom were
male and 69 were female. Genetic results of F2 G20210A, FVL G1691A, MTHFR C677T and MTHFR A1298C
were examined. FLV gene distributions were statistically different between genders (38.8% of men; 16.5% of
women). This difference was also statistically significant (p = 0.003).
Conclusion: The hemogram parameters were found to be insufficient markers. VDU was seen to be a clinically
necessary marker in diagnosis; and genetic outcomes were important in initiating appropriate treatment in the
early period. These results also show that there are differences according to gender in determining thrombotic risk.
Keywords
thrombosis, deep vein thrombosis, genetics, factor V Leiden
About this articleTitle
Investigation of clinical and genetic factors in patients with deep vein thrombosis. A retrospective study
Journal
Issue
Article type
Research paper
Pages
96-101
Published online
2021-01-07
Page views
404
Article views/downloads
547
DOI
10.5603/AA.2020.0017
Bibliographic record
Acta Angiologica 2020;26(3):96-101.
Keywords
thrombosis
deep vein thrombosis
genetics
factor V Leiden
Authors
Nihal İnandıklıoğlu
Hacı Alper Uzun
Ferit Çiçekçioğlu
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