open access

Vol 26, No 2 (2020)
Case report
Published online: 2020-07-29
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Type I cryoglobulinemia related to Sjögren’s syndrome and MGUS: a case report

Kamil Klimas, Rafał Małecki
DOI: 10.5603/AA.2020.0013
·
Acta Angiologica 2020;26(2):81-84.

open access

Vol 26, No 2 (2020)
Case reports
Published online: 2020-07-29

Abstract

Cryoglobulinemia is a rare disease caused by the specific antibodies which precipitate at low temperatures
being present within the blood serum. It is observed in the course of disorders such as autoimmune diseases,
lymphoproliferative neoplasms, and infectious diseases — mainly HCV infections. Three types of cryoglobulinemia
have been identified, differing in the type of immunoglobulins involved and symptoms being manifested. We are
presenting a case of a 61-year-old female patient with type I cryoglobulinemia related to Sjögren’s syndrome
and complicated by monoclonal gammopathy of undetermined significance.

Abstract

Cryoglobulinemia is a rare disease caused by the specific antibodies which precipitate at low temperatures
being present within the blood serum. It is observed in the course of disorders such as autoimmune diseases,
lymphoproliferative neoplasms, and infectious diseases — mainly HCV infections. Three types of cryoglobulinemia
have been identified, differing in the type of immunoglobulins involved and symptoms being manifested. We are
presenting a case of a 61-year-old female patient with type I cryoglobulinemia related to Sjögren’s syndrome
and complicated by monoclonal gammopathy of undetermined significance.

Get Citation

Keywords

cryoglobulinemia, monoclonal gammopathy of uncertain significance (MGUS), Sjögren’s syndrome (SS)

About this article
Title

Type I cryoglobulinemia related to Sjögren’s syndrome and MGUS: a case report

Journal

Acta Angiologica

Issue

Vol 26, No 2 (2020)

Article type

Case report

Pages

81-84

Published online

2020-07-29

DOI

10.5603/AA.2020.0013

Bibliographic record

Acta Angiologica 2020;26(2):81-84.

Keywords

cryoglobulinemia
monoclonal gammopathy of uncertain significance (MGUS)
Sjögren’s syndrome (SS)

Authors

Kamil Klimas
Rafał Małecki

References (6)
  1. Takada S, Shimizu T, Hadano Y, et al. Cryoglobulinemia (review). Mol Med Rep. 2012; 6(1): 3–8.
  2. Muchtar E, Magen H, Gertz MA. How I treat cryoglobulinemia. Blood. 2017; 129(3): 289–298.
  3. Huang Yf, Cheng Q, Jiang Cm, et al. The immune factors involved in the pathogenesis, diagnosis, and treatment of Sjogren's syndrome. Clin Dev Immunol. 2013; 2013: 160491.
  4. Pillemer SR. Lymphoma and other malignancies in primary Sjögren's syndrome. Ann Rheum Dis. 2006; 65(6): 704–706.
  5. Tomi AL, Belkhir R, Nocturne G, et al. Brief report: monoclonal gammopathy and risk of lymphoma and multiple myeloma in patients with primary Sjögren's syndrome. Arthritis Rheumatol. 2016; 68(5): 1245–1250.
  6. Brito-Zerón P, Retamozo S, Gandía M, et al. Monoclonal gammopathy related to Sjögren syndrome: a key marker of disease prognosis and outcomes. J Autoimmun. 2012; 39(1-2): 43–48.

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