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Type I cryoglobulinemia related to Sjögren’s syndrome and MGUS: a case report
, 1
Affiliations- Department of Angiology, Hypertension, and Diabetology, Wroclaw Medical University, Wroclaw, Poland
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Abstract
Cryoglobulinemia is a rare disease caused by the specific antibodies which precipitate at low temperatures
being present within the blood serum. It is observed in the course of disorders such as autoimmune diseases,
lymphoproliferative neoplasms, and infectious diseases — mainly HCV infections. Three types of cryoglobulinemia
have been identified, differing in the type of immunoglobulins involved and symptoms being manifested. We are
presenting a case of a 61-year-old female patient with type I cryoglobulinemia related to Sjögren’s syndrome
and complicated by monoclonal gammopathy of undetermined significance.
Abstract
Cryoglobulinemia is a rare disease caused by the specific antibodies which precipitate at low temperatures
being present within the blood serum. It is observed in the course of disorders such as autoimmune diseases,
lymphoproliferative neoplasms, and infectious diseases — mainly HCV infections. Three types of cryoglobulinemia
have been identified, differing in the type of immunoglobulins involved and symptoms being manifested. We are
presenting a case of a 61-year-old female patient with type I cryoglobulinemia related to Sjögren’s syndrome
and complicated by monoclonal gammopathy of undetermined significance.
Keywords
cryoglobulinemia, monoclonal gammopathy of uncertain significance (MGUS), Sjögren’s syndrome (SS)
About this articleTitle
Type I cryoglobulinemia related to Sjögren’s syndrome and MGUS: a case report
Journal
Issue
Article type
Case report
Pages
81-84
Published online
2020-07-29
Page views
466
Article views/downloads
621
DOI
10.5603/AA.2020.0013
Bibliographic record
Acta Angiologica 2020;26(2):81-84.
Keywords
cryoglobulinemia
monoclonal gammopathy of uncertain significance (MGUS)
Sjögren’s syndrome (SS)
Authors
Kamil Klimas
Rafał Małecki
References (6)- Takada S, Shimizu T, Hadano Y, et al. Cryoglobulinemia (review). Mol Med Rep. 2012; 6(1): 3–8.
- Muchtar E, Magen H, Gertz MA. How I treat cryoglobulinemia. Blood. 2017; 129(3): 289–298.
- Huang Yf, Cheng Q, Jiang Cm, et al. The immune factors involved in the pathogenesis, diagnosis, and treatment of Sjogren's syndrome. Clin Dev Immunol. 2013; 2013: 160491.
- Pillemer SR. Lymphoma and other malignancies in primary Sjögren's syndrome. Ann Rheum Dis. 2006; 65(6): 704–706.
- Tomi AL, Belkhir R, Nocturne G, et al. Brief report: monoclonal gammopathy and risk of lymphoma and multiple myeloma in patients with primary Sjögren's syndrome. Arthritis Rheumatol. 2016; 68(5): 1245–1250.
- Brito-Zerón P, Retamozo S, Gandía M, et al. Monoclonal gammopathy related to Sjögren syndrome: a key marker of disease prognosis and outcomes. J Autoimmun. 2012; 39(1-2): 43–48.