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h
84.224 776.746 m
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h
85.8 776.988 m
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86.487 775.348 86.525 775.59 86.525 775.788 c
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85.8 776.988 l
h
88.467 775.907 m
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89.678 774.752 89.719 774.629 y
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88.708 773.913 88.467 773.951 88.346 773.951 c
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88.467 775.907 l
h
90.326 775.71 m
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90.285 776.027 90.406 776.347 90.568 776.627 c
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91.899 776.746 91.779 776.627 91.741 776.548 c
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91.699 775.628 91.779 775.468 91.82 775.348 c
91.899 775.188 92.061 775.031 92.224 774.949 c
92.306 774.949 92.386 774.871 92.465 774.871 c
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92.91 774.83 93.072 774.871 93.155 774.871 c
93.234 774.908 93.355 774.99 93.438 775.069 c
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93.355 774.193 93.114 774.07 92.872 774.032 c
92.627 773.951 92.386 773.913 92.182 773.913 c
92.023 773.913 91.861 773.951 91.699 773.951 c
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90.971 774.312 90.73 774.551 90.568 774.83 c
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90.326 775.71 l
h
95.011 775.669 m
95.294 776.306 l
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96.022 777.547 l
96.142 777.547 96.304 777.465 96.467 777.346 c
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94.245 774.39 94.324 774.472 94.366 774.472 c
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95.011 775.669 l
h
96.184 775.389 m
96.266 775.389 96.346 775.43 y
96.346 775.468 96.304 775.59 96.225 775.71 c
96.142 775.829 96.063 775.948 96.022 775.989 c
95.984 776.068 95.901 776.109 95.859 776.109 c
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95.618 775.628 l
95.577 775.549 l
95.577 775.43 l
95.659 775.389 95.739 775.389 v
96.184 775.389 l
f*
62.751 782.494 m
64.816 783.084 l
62.946 783.998 l
62.978 784.36 l
65.695 783.008 l
63.642 782.417 l
65.567 781.489 l
62.647 780.62 l
62.679 780.984 l
64.681 781.565 l
62.751 782.494 l
h
65.574 787.367 m
63.807 787.212 l
63.972 787.562 l
65.306 787.675 l
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65.717 787.67 l
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66.647 786.873 l
65.574 787.367 l
h
66.226 791.601 m
66.582 792.036 l
66.701 792.181 66.831 792.306 66.972 792.413 c
67.125 792.521 67.284 792.599 67.449 792.644 c
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68.339 789.91 l
66.226 791.601 l
h
66.68 791.669 m
68.312 790.364 l
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66.68 791.669 l
h
70.767 796.057 m
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72.439 794.575 l
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70.767 796.057 l
h
71.162 795.431 m
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72.157 794.762 l
71.162 795.431 l
h
76.274 798.458 m
77.542 796.743 l
77.77 798.792 l
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76.506 797.604 l
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76.051 796.348 l
76.274 798.458 l
h
81.311 799.125 m
83.197 796.864 l
83.338 798.851 l
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81.589 798.29 l
81.447 796.288 l
81.112 796.312 l
81.311 799.125 l
h
86.804 797.988 m
87.126 797.884 l
86.286 795.329 l
85.964 795.432 l
86.804 797.988 l
h
90.579 793.643 m
90.367 793.308 l
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89.039 794.283 88.984 794.527 88.994 794.79 c
89.002 795.021 89.066 795.231 89.185 795.42 c
89.206 795.453 89.219 795.474 89.225 795.484 c
89.308 795.614 89.406 795.724 89.521 795.814 c
89.627 795.896 89.748 795.962 89.881 796.011 c
90.131 796.1 90.369 796.126 90.595 796.091 c
90.821 796.056 91.013 795.989 91.172 795.891 c
91.393 795.754 91.561 795.582 91.674 795.375 c
91.464 795.043 l
91.381 795.304 91.224 795.506 90.992 795.649 c
90.91 795.699 90.825 795.737 90.738 795.762 c
90.651 795.787 90.559 795.8 90.462 795.8 c
90.273 795.801 90.091 795.756 89.915 795.664 c
89.74 795.572 89.605 795.453 89.513 795.306 c
89.396 795.122 89.334 794.932 89.326 794.736 c
89.316 794.546 89.355 794.365 89.443 794.194 c
89.488 794.108 89.54 794.031 89.6 793.964 c
89.661 793.898 89.732 793.839 89.815 793.788 c
89.84 793.772 l
90.043 793.647 90.289 793.603 90.579 793.643 c
h
94.176 792.73 m
93.749 793.215 l
93.983 793.416 l
95.056 792.196 l
94.822 791.995 l
94.395 792.48 l
92.577 790.918 l
92.358 791.168 l
94.176 792.73 l
h
97.551 788.271 m
96.061 786.739 l
98.143 786.873 l
98.298 786.543 l
95.26 786.371 l
96.74 787.897 l
94.604 787.75 l
96.692 789.945 l
96.848 789.614 l
95.409 788.121 l
97.551 788.271 l
h
98.729 782.13 m
98.716 782.28 98.677 782.415 98.612 782.534 c
98.547 782.653 98.459 782.759 98.345 782.852 c
98.232 782.945 98.106 783.013 97.967 783.054 c
97.823 783.099 97.677 783.115 97.531 783.102 c
97.337 783.085 97.159 783.022 96.997 782.911 c
96.835 782.8 96.713 782.659 96.63 782.486 c
96.547 782.314 96.514 782.132 96.53 781.94 c
96.548 781.748 96.612 781.574 96.725 781.417 c
96.837 781.26 96.981 781.141 97.158 781.061 c
97.335 780.98 97.522 780.948 97.72 780.965 c
97.873 780.978 98.016 781.019 98.148 781.086 c
98.272 781.147 98.382 781.233 98.477 781.346 c
98.568 781.451 98.636 781.571 98.681 781.708 c
98.726 781.843 98.742 781.984 98.729 782.13 c
h
99.038 782.157 m
99.055 781.967 99.034 781.784 98.975 781.606 c
98.917 781.429 98.831 781.271 98.716 781.133 c
98.601 780.995 98.46 780.881 98.292 780.791 c
98.123 780.702 97.943 780.648 97.75 780.632 c
97.555 780.615 97.372 780.635 97.198 780.692 c
97.025 780.748 96.863 780.838 96.714 780.961 c
96.573 781.078 96.457 781.217 96.37 781.379 c
96.283 781.542 96.23 781.719 96.213 781.912 c
96.19 782.168 96.233 782.408 96.341 782.632 c
96.449 782.856 96.606 783.039 96.812 783.18 c
97.02 783.328 97.251 783.412 97.502 783.434 c
97.753 783.455 97.995 783.413 98.225 783.306 c
98.455 783.199 98.643 783.046 98.787 782.846 c
98.931 782.647 99.015 782.416 99.038 782.157 c
f*
67.912 769.034 m
70.123 769.806 l
68.426 767.49 l
68.185 767.746 l
69.293 769.196 l
67.362 768.527 l
68.179 770.387 l
66.626 769.398 l
66.394 769.644 l
68.849 771.157 l
67.912 769.034 l
h
71.809 768.337 m
73.034 767.551 l
72.865 767.294 l
71.924 767.897 l
71.51 767.267 l
72.427 766.679 l
72.258 766.422 l
71.341 767.01 l
70.781 766.158 l
71.722 765.555 l
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70.328 766.083 l
71.809 768.337 l
h
74.637 766.729 m
75.173 766.547 l
75.35 766.486 75.514 766.409 75.664 766.314 c
75.819 766.209 75.947 766.088 76.047 765.95 c
76.153 765.802 76.222 765.633 76.256 765.443 c
76.272 765.349 76.274 765.249 76.263 765.145 c
76.252 765.041 76.227 764.932 76.187 764.819 c
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76.102 764.573 75.984 764.386 75.825 764.226 c
75.66 764.064 75.449 763.958 75.192 763.906 c
74.934 763.855 74.643 763.885 74.318 763.996 c
73.751 764.188 l
74.637 766.729 l
h
74.857 766.33 m
74.173 764.369 l
74.369 764.303 l
74.736 764.178 75.051 764.172 75.313 764.287 c
75.568 764.398 75.745 764.597 75.845 764.882 c
75.852 764.902 l
75.905 765.056 75.927 765.201 75.917 765.338 c
75.907 765.475 75.865 765.605 75.791 765.727 c
75.646 765.967 75.388 766.149 75.017 766.276 c
74.857 766.33 l
h
78.891 764.126 m
78.224 765.75 l
78.612 765.697 l
79.111 764.469 l
79.938 765.513 l
80.319 765.459 l
79.226 764.079 l
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78.727 762.967 l
78.891 764.126 l
h
84.123 763.667 m
84.178 763.276 l
83.974 763.12 83.749 763.024 83.503 762.99 c
83.248 762.955 83.001 762.985 82.764 763.082 c
82.526 763.179 82.326 763.332 82.163 763.539 c
82.018 763.721 81.931 763.923 81.899 764.144 c
81.894 764.182 81.89 764.207 81.889 764.218 c
81.867 764.369 81.871 764.516 81.901 764.658 c
81.928 764.789 81.978 764.916 82.048 765.038 c
82.182 765.265 82.347 765.437 82.543 765.553 c
82.739 765.669 82.929 765.74 83.115 765.766 c
83.374 765.802 83.614 765.777 83.835 765.69 c
83.89 765.303 l
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82.783 765.356 82.705 765.307 82.63 765.245 c
82.485 765.127 82.375 764.976 82.3 764.794 c
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86.782 766.387 m
85.685 765.948 l
85.569 766.233 l
87.18 766.876 l
86.803 764.158 l
88.083 764.669 l
88.199 764.385 l
86.41 763.67 l
86.782 766.387 l
h
88.638 767.675 m
91.554 767.141 l
90.369 768.753 l
90.649 768.954 l
92.314 766.69 l
89.394 767.212 l
90.587 765.588 l
90.315 765.393 l
88.638 767.675 l
h
92.051 770.215 m
92.989 771.32 l
93.227 771.123 l
92.506 770.274 l
93.088 769.791 l
93.791 770.619 l
94.028 770.422 l
93.326 769.594 l
94.114 768.941 l
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ET
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(Address for correspondence \(Adres do korespondencji\):)Tj
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(Address for correspondence \(Adres do korespondencji\):)Tj
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(Address for correspondence \(Adres do korespondencji\):)Tj
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(Address for correspondence \(Adres do korespondencji\):)Tj
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[(Dr n. med. Jerzy Windyga, Instytut Hematologii i Transfuzjologii, ul. Chocimska 5, 00957 Warszawa)]TJ
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[(tel. +48 \(22\) 849 75 38, fax: +48 \(22\) 848 89 80)]TJ
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(Prevention of recurrent thrombosis)Tj
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0.024 Tw
(in antiphospholipid antibody syndrome)Tj
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(Jerzy Windyga)Tj
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(Outpatient Clinic of Hemostatic Disorders Institute of Hematology and Blood Transfusion, Warsaw, Poland)Tj
T*
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(\(Samodzielna Pracownia Krzepnicia Krwi Instytutu Hematologii i Transfuzjologii w Warszawie\))Tj
ET
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(Background.)Tj
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(Background.)Tj
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[(Background.)30( )]TJ
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(The antiphospholipid antibody syndrome \(APS\) is an autoimmune disorder in which venous and)Tj
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(arterial thrombosis or foetal loss may occur in patients with antiphospholipid antibodies \(APA\). The optimal)Tj
0 -1.4433 TD
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0.0423 Tw
[(intensity of oral anticoagulant \(OA\) therapy for the prevention of thromboembolism in patients with APS is)]TJ
T*
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(controversial. The aim of this study was to assess the efficacy of anticoagulation with a targeted International)Tj
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(Material and methods.)Tj
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(Material and methods.)Tj
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(Material and methods.)Tj
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[(Material and methods.)28.6( )]TJ
10.1789 0 TD
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(The patient group consisted of 21 patients \(9 women and 12 men, aged 1467,)Tj
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-0.028 Tw
(mean 33.9 17.1 years\) with APS. Twenty one patients \(14 women and 7 men, aged 2654, mean 44.4 )Tj
0 -1.4467 TD
-0.0003 Tc
0.0417 Tw
( 9.7 years\) with inherited thrombophilia formed the reference group. APS patients and reference group-)Tj
0 -1.4433 TD
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(subjects received oral anticoagulants \(acenocoumarol\) \(targeted INR = 2.03.0\) to prevent recurrence of)Tj
T*
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(thromboembolism. The INR was determined with rabbit brain thromboplastin reagent \(Biomed-WSS, War-)Tj
0 -1.4467 TD
0.0847 Tw
(saw\) and Behring Thromborel S thromboplastin reagent. Prothrombin fragment 1+2 \(F1+2\) levels were)Tj
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(Results.)Tj
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(Results.)Tj
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(Results.)Tj
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(Results.)Tj
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[(Results.)31( )]TJ
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(Prevention of recurrent thrombosis with acenocoumarol was followed-up in 21 patients with APS for)Tj
-3.5517 -1.4467 TD
0.0803 Tw
(38 years \(95 patient-years\) and in 21 patients with inherited thrombophilia for 25 years \(86 patient-)Tj
0 -1.4433 TD
0.0484 Tw
[(years\). Only in one APS patient a single recurrence of deep venous thrombosis was recorded \(the patient)]TJ
T*
-0.0001 Tc
0.0167 Tw
(decided to stop taking acenocoumarol\). During acenocoumarol treatment, 3 minor bleeding episodes were)Tj
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T*
0.0404 Tw
(inherited thrombophilia receiving acenocoumarol for prevention of recurrent thrombosis, F1+2 levels were)Tj
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(within the normal range over a 16-week observation period.)Tj
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(Conclusions.)Tj
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[(Conclusions.)29.5( )]TJ
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(Our current results indicate that oral anticoagulant therapy with a targeted INR of 2.03.0)Tj
-5.5959 -1.4433 TD
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(prevents recurrences of venous and/or arterial thrombosis in patients with antiphospholipid antibody syn-)Tj
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(drome and carries no significant risk of hemorrhagic complications.)Tj
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(Key words: antiphospholipid antibody syndrome, lupus anticoagulant, oral anticoagulants,)Tj
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(thromboprophylaxis)Tj
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[(Wstp.)31.3( )]TJ
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(Zesp antyfosfolipidowy \(APS\) jest chorob autoimmunologiczn, definiowan jako wspistnienie)Tj
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T*
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(ciy. Kontrowersje wzbudza intensywno wtrnej profilaktyki przeciwzakrzepowej za pomoc doustnego)Tj
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(antykoagulantu \(OA\) u pacjentw z APS. Celem niniejszej pracy byo ustalenie, czy stosowanie OA w dawce)Tj
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(Materia i metody.)Tj
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(Materia i metody.)Tj
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0.0003 Tc
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(wtrnej profilaktyki przeciwzakrzepowej pacjenci z obu grup przyjmowali OA \(acenokumarol\) \(INR 2,03,0\).)Tj
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T*
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(Wyniki.)Tj
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(Wyniki.)Tj
0.03 0.03 TD
(Wyniki.)Tj
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[(Wyniki.)30.9( )]TJ
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(przez 38 lat \(95 pacjentolat\) u 21 chorych z APS oraz przez 25 lat \(86 pacjentolat\) u 21 osb z wrodzon)Tj
T*
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[(trombofili. Tylko u 1 pacjenta z APS, ktry samowolnie przesta przyjmowa acenokumarol, wystpi 1 nawr)-9.2(t)]TJ
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0.0018 Tw
(w okresie 16-tygodniowej obserwacji.)Tj
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0.0311 Tc
0 Tw
(Wnioski.)Tj
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(Wnioski.)Tj
0.03 0.03 TD
(Wnioski.)Tj
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0.015 -0.015 TD
[(Wnioski.)31.1( )]TJ
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T*
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(niami krwotocznymi.)Tj
/F2 1 Tf
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(Sowa kluczowe: zesp antyfosfolipidowy, antykoagulant toczniowy, doustne antykoagulanty,)Tj
ET
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(Introduction)Tj
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-0.0102 Tw
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(bosis or foetal loss may occur in patients with antipho-)Tj
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(spholipid antibodies \(APA\) [1]. The most important re-)Tj
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(presentatives of APA are lupus anticoagulant \(LA\) and)Tj
0 -1.4467 TD
-0.0102 Tc
0.0518 Tw
(anticardiolipin antibodies \(ACL\). A)Tj
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0.0002 Tc
0.0555 Tw
(ntiphospholipid anti-)Tj
-14.9833 -1.4433 TD
-0.0002 Tc
-0.0556 Tw
[(body syndrome)-0.2( )]TJ
7.0632 0 TD
-0.01 Tc
-0.0605 Tw
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-0.0104 Tc
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1.5733 -1.4467 TD
-0.0032 Tc
-0.0694 Tw
(Although it is generally known that each patient with)Tj
-1.5733 -1.4433 TD
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(APS and history of venous thromboembolism \(VTE\))Tj
T*
-0.0005 Tc
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(must receive secondary thromboprophylaxis, there is)Tj
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-0.0001 Tc
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(no agreement as to its intensity [37]. It was the main)Tj
0 -1.4433 TD
-0.0006 Tc
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(aim of this paper to assess whether oral anticoagulant)Tj
T*
-0.0004 Tc
0.0722 Tw
(at a dose sufficient to achieve a targeted international)Tj
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0.1389 Tw
(normalized ratio \(INR\) of 2.0 to 3.0 adequately pro-)Tj
0 -1.4433 TD
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(tects patients with APS against recurrences of venous)Tj
T*
-0.0001 Tw
(and/or arterial thrombosis.)Tj
/F4 1 Tf
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0.0021 Tc
0.0091 Tw
(Material and methods)Tj
/F2 1 Tf
9 0 0 9 76.5 137.435 Tm
-0.0001 Tc
0.0736 Tw
(The patient group consisted of 21 patients \(9 wo-)Tj
-1.5733 -1.4467 TD
-0.0002 Tc
-0.0511 Tw
(men and 12 men, aged 1467, mean 33.9 17.1 years,)Tj
0 -1.4433 TD
-0.0006 Tc
0.0049 Tw
(median age 26 years\) with APS registered in the Blood)Tj
T*
-0.0001 Tc
0.023 Tw
(Coagulation Disorders Clinic at the Institute of Hema-)Tj
0 -1.4467 TD
0.0136 Tc
0.1492 Tw
(tology and Blood Transfusion \(IHiT\) in Warsaw for)Tj
0 -1.4433 TD
-0.0008 Tc
0.0067 Tw
(3 years or more. The diagnosis of APS had been based)Tj
/F4 1 Tf
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0.003 Tc
0 Tw
(Wstp)Tj
/F2 1 Tf
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-0.0003 Tc
-0.0044 Tw
(Zesp antyfosfolipidowy \(APS\) jest chorob auto-)Tj
-1.89 -1.4433 TD
-0.0695 Tw
(immunologiczn, definiowan jako wspistnienie prze-)Tj
0 -1.4467 TD
-0.0077 Tc
-0.0694 Tw
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0 -1.4433 TD
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0.0509 Tw
(nicznymi, jak ylna lub ttnicza zakrzepica, poronienia)Tj
T*
-0.0005 Tc
-0.0134 Tw
(lub przedwczesne porody [1]. Najwaniejszymi przed-)Tj
0 -1.4467 TD
0.0135 Tc
0.1867 Tw
(stawicielami APA s: antykoagulant toczniowy \(LA\))Tj
0 -1.4433 TD
-0.0006 Tc
-0.0305 Tw
[(i przeciwciaa antykardiolipinowe \(ACL\). Uwaa si, e)]TJ
T*
-0.0004 Tc
0 Tw
(APS jest najczstsz przyczyn nabytej trombofilii [2].)Tj
1.5733 -1.4467 TD
0.0081 Tc
0.1389 Tw
(Cho powszechnie wiadomo, e kady chory ze)Tj
-1.5733 -1.4433 TD
-0.0003 Tc
0.0722 Tw
(stwierdzonym APS i przebytym epizodem ylnej cho-)Tj
T*
0.0006 Tc
0.1389 Tw
(roby zakrzepowo-zatorowej musi by objty wtrn)Tj
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-0.0007 Tc
0.0733 Tw
(profilaktyk przeciwzakrzepow, to nie ma zgodnoci)Tj
0 -1.4433 TD
-0.0001 Tc
0.0472 Tw
(w zakresie intensywnoci tej profilaktyki [37]. Gw-)Tj
T*
-0.0002 Tc
-0.0532 Tw
(nym celem niniejszej pracy byo ustalenie, czy stosowa-)Tj
0 -1.4467 TD
-0.0005 Tc
0.1037 Tw
(nie doustnego antykoagulantu \(OA\) w dawce zapew-)Tj
0 -1.4433 TD
0.0134 Tc
0.1945 Tw
(niajcej utrzymywanie wartoci midzynarodowego)Tj
T*
0.0039 Tc
0.1389 Tw
(wspczynnika znormalizowanego \(INR\) w granicach)Tj
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-0.0007 Tc
-0.0509 Tw
(2,03,0 skutecznie zabezpiecza pacjentw z APS przed)Tj
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(nawrotami ylnej i/lub ttniczej zakrzepicy.)Tj
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0.0068 Tw
(Materia i metody)Tj
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0.068 Tw
(Badaniami objto 21 pacjentw \(9 kobiet i 12 m-)Tj
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-0.0407 Tw
(czyzn\) w wieku 1467 lat \(rednia wieku wynosia 33,9 )Tj
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( 17,1 roku; mediana 26 lat\) zarejestrowanych od)Tj
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(3 lub wicej lat w Poradni Zaburze Krzepnicia Krwi)Tj
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[(Prevention of thrombosis in APS patients)-6(,)9.2( )]TJ
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(on the criteria established by Wilson et al. [8]. Those)Tj
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T*
-0.0018 Tc
-0.0695 Tw
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(of thrombotic events.)Tj
1.5733 -1.4433 TD
-0.0003 Tc
0.1074 Tw
(The reference group consisted of twenty-one pa-)Tj
-1.5733 -1.4467 TD
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-0.0444 Tw
(tients \(14 women and 7 men, aged 2654 mean 44.4 )Tj
0 -1.4433 TD
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( 9.7 years, median age 42 years\) with inherited throm-)Tj
T*
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-0.0009 Tw
(bophilia registered in the Blood Coagulation Disorders)Tj
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(Clinic at the IHiT in Warsaw for )Tj
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[( 2 years. Nineteen)]TJ
-15.7333 -1.4433 TD
-0.0005 Tc
-0.0181 Tw
(patients were carriers of factor V Leiden \(16 heterozy-)Tj
T*
-0.0003 Tc
-0.0254 Tw
(gotes and 3 homozygotes\). In one patient, heterozygo-)Tj
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(sity for factor V Leiden coexisted with protein S defi-)Tj
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(ciency. One patient had antithrombin \(AT\) deficiency.)Tj
T*
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(Another was heterozygous for the G20210A mutation)Tj
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-0.0005 Tc
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(of the prothrombin. The reference group-subjects re-)Tj
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(ceived oral anticoagulants after an episode of VTE, tar-)Tj
T*
-0.0024 Tc
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(geted INR of 2.03.0. Antithrombin and protein C were)Tj
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(was assayed by an ELISA method \(Diagnostica Stago\).)Tj
T*
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(Factor V Leiden genotype and the G20210A mutation)Tj
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-0.0005 Tc
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(in the prothrombin gene were determined as descri-)Tj
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0.0022 Tw
(bed by Bertina et al. [9], and Poort et al. [10].)Tj
1.5733 -1.4433 TD
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(The efficacy of therapy was assessed on the basis of)Tj
-1.5733 -1.4467 TD
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(clinical and laboratory analysis. Clinical analysis consi-)Tj
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(sted in assessing the frequency of recurrences of throm-)Tj
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(bosis and bleeding episodes. Laboratory analysis consi-)Tj
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(sted in measurement of the prothrombin fragment 1+2)Tj
0 -1.4433 TD
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T*
-0.0006 Tc
0.0715 Tw
(that purpose, every 4 weeks, blood samples were ta-)Tj
0 -1.4467 TD
0.0078 Tc
0.1388 Tw
[(ken from 10 APS patients receiving acenocoumarol.)]TJ
0 -1.4433 TD
-0.0099 Tc
-0.0691 Tw
(Within 16 weeks, 4 blood samples were taken from each)Tj
T*
-0.0142 Tc
-0.0695 Tw
(patient, a total of 40 samples. Additionally, identical blood)Tj
0 -1.4467 TD
0.0049 Tc
0.1388 Tw
(samples were taken from 10 patients with inherited)Tj
0 -1.4433 TD
-0.0002 Tc
-0.0389 Tw
(thrombophilia receiving OA in secondary thrombopro-)Tj
T*
-0.0013 Tc
0 Tw
(phylaxis.)Tj
1.5733 -1.4467 TD
-0.0001 Tc
-0.0601 Tw
(It is known that in the presence of LA results of pro-)Tj
-1.5733 -1.4433 TD
-0.0005 Tc
-0.0046 Tw
(thrombin time \(PT\) measurement may vary depending)Tj
T*
-0.0003 Tc
-0.0117 Tw
(on the kind of thromboplastin reagent used. As the an-)Tj
0 -1.4467 TD
-0.0002 Tc
0.0993 Tw
(ticoagulant intensity in this study was assesed by me-)Tj
0 -1.4433 TD
-0.0286 Tw
(asuring INR with Polish rabbit brain thromboplastin re-)Tj
T*
-0.0135 Tc
-0.0695 Tw
[(agent \(Biomed, WSS, Warsaw\), it was necessary to check)]TJ
0 -1.4467 TD
-0.0002 Tc
0.0346 Tw
(its sensitivity to the presence of LA. For that purpose,)Tj
0 -1.4433 TD
-0.0003 Tc
0.034 Tw
(prothrombin time was measured in two groups of pa-)Tj
T*
0.0002 Tc
-0.0599 Tw
(tients 20 with LA and 20 with inherited thrombophi-)Tj
0 -1.4467 TD
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0.025 Tw
(lia, receiving oral anticoagulant in secondary thrombo-)Tj
0 -1.4433 TD
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-0.0691 Tw
[(prophylaxis, using Polish thromboplastin reagent as well)]TJ
T*
-0.0005 Tc
-0.013 Tw
(as a foreign one Thromborel S \(Dade Behring, Mar-)Tj
0 -1.4467 TD
-0.0019 Tc
-0.069 Tw
(burg, Germany\) considered insensitive to LA [11]. Then)Tj
0 -1.4433 TD
-0.0006 Tc
-0.0416 Tw
(INR was calculated for each PT measurement using co-)Tj
T*
-0.0004 Tc
0.0278 Tw
(nversion tables supplied by the producers. The results)Tj
0 -1.4467 TD
-0.0011 Tc
0.0222 Tw
(were compared.)Tj
26.6167 73.6667 TD
-0.0002 Tc
0.0491 Tw
(Instytutu Hematologii i Transfuzjologii w Warszawie z)Tj
0 -1.4433 TD
-0.0091 Tc
-0.0694 Tw
(powodu zespou antyfosfolipidowego. Rozpoznanie APS)Tj
T*
-0.0004 Tc
0.0111 Tw
(ustalono na podstawie kryteriw opracowanych przez)Tj
0 -1.4467 TD
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-0.0518 Tw
(Wilson i wsp. [8]. Badani chorzy przebyli yln i/lub tt-)Tj
0 -1.4433 TD
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0.0135 Tw
(nicz zakrzepic i w ramach wtrnej profilaktyki prze-)Tj
T*
0.0129 Tc
0.1389 Tw
(ciwzakrzepowej przyjmowali doustny antykoagulant)Tj
0 -1.4467 TD
0.0131 Tc
0.1583 Tw
(\(acenokumarol\) w dawce zapewniajcej utrzymanie)Tj
0 -1.4433 TD
-0.0002 Tc
0.0014 Tw
(wartoci INR w przedziale 2,03,0.)Tj
1.89 -1.4433 TD
-0.0234 Tc
-0.0695 Tw
(Grup porwnawcz stanowio 21 pacjentw \(14 ko-)Tj
-1.89 -1.4467 TD
-0.0211 Tc
0.1277 Tw
[(biet)-7.8( i)-20.9( 7)-20.9( )]TJ
3.5506 0 TD
-0.0002 Tc
0.1068 Tw
(mczyzn\) w wieku 2654 lat \(rednia wieku)Tj
-3.5506 -1.4433 TD
0.0402 Tw
(wynosia 44,4 9,7 roku; mediana 42 lata\), bdcych)Tj
T*
-0.0004 Tc
0.0564 Tw
(pod opiek Poradni Zaburze Krzepnicia Krwi Insty-)Tj
0 -1.4467 TD
-0.0002 Tc
-0.059 Tw
(tutu Hematologii i Transfuzjologii w Warszawie od 2 lat)Tj
0 -1.4433 TD
0.0001 Tc
0.0389 Tw
(lub duej z powodu wrodzonej trombofilii. Dziewit-)Tj
T*
-0.0002 Tc
-0.0055 Tw
(nastu pacjentw byo obarczonych mutacj genu czyn-)Tj
0 -1.4467 TD
-0.0001 Tc
0.0019 Tw
(nika V typu Leiden \(16 heterozygot i 3 osoby homozy-)Tj
0 -1.4433 TD
-0.0005 Tc
0.0541 Tw
(gotyczne\), przy czym w 1 przypadku ze stanem hete-)Tj
T*
0 Tc
0.1189 Tw
(rozygotycznym wobec tej mutacji wspistnia niedo-)Tj
0 -1.4467 TD
-0.0002 Tc
-0.0257 Tw
(br biaka S. U 1 chorego wykryto niedobr antytrom-)Tj
0 -1.4433 TD
-0.0005 Tc
0.0277 Tw
(biny \(AT\). Take w 1 przypadku stwierdzono stan he-)Tj
T*
-0.0094 Tc
-0.0689 Tw
(terozygotyczny wobec mutacji G20210A genu protrom-)Tj
0 -1.4467 TD
-0.0002 Tc
0.0032 Tw
(biny. Pacjenci ci otrzymywali OA po przebytym epizo-)Tj
0 -1.4433 TD
-0.0131 Tc
-0.0694 Tw
(dzie ylnej choroby zakrzepowo-zatorowej, a INR utrzy-)Tj
T*
-0.0005 Tc
0.0445 Tw
(mywa si w granicach 2,03,0. Zawarto AT i biaka)Tj
0 -1.4467 TD
-0.0004 Tc
0.0008 Tw
(C oznaczono za pomoc zestaww firmy Behring. An-)Tj
0 -1.4433 TD
-0.0207 Tw
(tygen wolnego biaka S oznaczono metod ELISA \(Dia-)Tj
T*
0.0746 Tw
(gnostica Stago\). Mutacj genu czynnika V typu Leiden)Tj
0 -1.4467 TD
-0.0002 Tc
0.0167 Tw
(oraz mutacj G20210A genu protrombiny wykrywano)Tj
0 -1.4433 TD
-0.0012 Tc
-0.069 Tw
(metodami opisanymi uprzednio przez Bertin i wsp. [9])Tj
T*
-0.0001 Tc
0.0014 Tw
(oraz Poorta i wsp. [10].)Tj
1.89 -1.4467 TD
-0.0037 Tc
-0.0695 Tw
[(Ocen skutecznoci prowadzonego leczenia stano-)]TJ
-1.89 -1.4433 TD
-0.0002 Tc
-0.0071 Tw
(wiy analiza kliniczna i laboratoryjna. W analizie klinicz-)Tj
T*
-0.003 Tc
-0.0694 Tw
(nej oceniano czsto nawrotw zakrzepicy i epizodw)Tj
0 -1.4467 TD
-0.0005 Tc
-0.0667 Tw
(krwawie, natomiast w analizie laboratoryjnej oznacza-)Tj
0 -1.4433 TD
-0.0006 Tc
-0.0491 Tw
(no marker aktywacji krzepnicia fragment protrom-)Tj
T*
0.0001 Tc
0.1277 Tw
[(biny 1+2 \(F1+2\). W tym celu od 10 chorych z APS)]TJ
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-0.0003 Tc
0.1355 Tw
(leczonych acenokumarolem pobierano co 4 tygodnie)Tj
0 -1.4433 TD
-0.0006 Tc
0.0806 Tw
(krew. W okresie 16 tygodni od kadego pacjenta po-)Tj
T*
-0.0003 Tc
-0.0654 Tw
(brano po 4 prbki krwi cznie 40 prbek. Dodatko-)Tj
0 -1.4467 TD
-0.0005 Tc
0.0358 Tw
(wo, w taki sam sposb pobierano krew od 10 pacjen-)Tj
0 -1.4433 TD
-0.0003 Tc
0.0484 Tw
(tw z wrodzon trombofili, przyjmujcych OA w ra-)Tj
T*
-0.0007 Tc
0.0036 Tw
(mach wtrnej profilaktyki przeciwzakrzepowej.)Tj
1.5733 -1.4467 TD
-0.0002 Tc
-0.0397 Tw
(Wiadomo, e w obecnoci LA wynik pomiaru czasu)Tj
-1.5733 -1.4433 TD
-0.0004 Tc
0.0491 Tw
(protrombinowego moe zmienia si w zalenoci od)Tj
T*
-0.0001 Tc
-0.0323 Tw
[(rodzaju uytej tromboplastyny. Poniewa w niniejszym)]TJ
0 -1.4467 TD
-0.0004 Tc
-0.0213 Tw
(badaniu stosowanie OA kontrolowano za pomoc cza-)Tj
0 -1.4433 TD
0.1078 Tw
(su protrombinowego oznaczanego przy uyciu krajo-)Tj
T*
-0.0002 Tc
-0.0189 Tw
(wej tromboplastyny mzgw krliczych \(Biomed, Wy-)Tj
0 -1.4467 TD
-0.0005 Tc
0.0011 Tw
(twrnia Surowic i Szczepionek, Warszawa\), konieczne)Tj
0 -1.4433 TD
0.0135 Tc
0.2232 Tw
(byo sprawdzenie jej wraliwoci na obecno LA.)Tj
T*
-0.0001 Tc
-0.01 Tw
(W tym celu w dwch grupach pacjentw u 20 osb)Tj
0 -1.4467 TD
-0.0389 Tw
(z LA i u 20 chorych z wrodzon trombofili, przyjmuj-)Tj
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0 -1.4433 TD
0.0966 Tw
(re, then again at 1700 G for 5 minutes. Platelet poor)Tj
T*
-0.0006 Tc
0.0312 Tw
(plasma was removed and frozen at 70C for analysis.)Tj
0 -1.4467 TD
-0.0051 Tc
-0.0691 Tw
(F1+2 levels were measured using an enzyme-linked im-)Tj
0 -1.4433 TD
-0.0006 Tc
0.1056 Tw
(munosorbent assay method \(Dade Behring, Marburg,)Tj
T*
-0.0286 Tw
(Germany\). The normal range established for this F1+2)Tj
0 -1.4467 TD
0.0002 Tc
-0.0028 Tw
(assay is < 1.1 nmol/l.)Tj
/F4 1 Tf
11 0 0 11 118.5 591.515 Tm
0.0027 Tc
0.0136 Tw
(Statistic evaluation)Tj
/F2 1 Tf
9 0 0 9 76.5 578.015 Tm
0.0194 Tc
0.1195 Tw
(Mean INR values were compared between two)Tj
-1.5733 -1.4433 TD
0.0199 Tc
0.0342 Tw
[(patient groups using Mann-Whitney U test. Value of)]TJ
T*
-0.0003 Tc
-0.0022 Tw
[(p)-20.3( )-22.5(<)-23.6( 0.05 was considered as significant.)]TJ
/F4 1 Tf
11 0 0 11 151.2 526.535 Tm
0.0028 Tc
0 Tw
(Results)Tj
/F2 1 Tf
9 0 0 9 76.5 513.035 Tm
0.0346 Tc
-0.0278 Tw
(Table I shows the relationship between the INR)Tj
-1.5733 -1.4467 TD
0.0284 Tw
(and kind of thromboplastin reagent used in the LA)Tj
0 -1.4433 TD
0.0489 Tc
0.2167 Tw
(patients group and in the group with inherited)Tj
T*
0.0289 Tc
-0.0689 Tw
(thrombophilia receiving acenocoumarol for the pre-)Tj
0 -1.4467 TD
0.0218 Tc
(vention of recurrent thrombosis. Differences betwe-)Tj
0 -1.4433 TD
0.0347 Tc
0.1079 Tw
(en INR values within each group were statisticaly)Tj
T*
0.0328 Tc
0 Tw
(insignificant.)Tj
1.5733 -1.4467 TD
-0.0002 Tc
0.0861 Tw
(Treatment with oral anticoagulants to prevent re-)Tj
-1.5733 -1.4433 TD
0.0481 Tw
(currencyrecurrence of thrombosis was followed up in)Tj
T*
-0.0003 Tc
0.003 Tw
(21 APS patients for 38 years \(95 patient-years\) and in)Tj
0 -1.4467 TD
-0.0002 Tc
0.0207 Tw
(21 patients with inherited thrombophilia for 25 years)Tj
0 -1.4433 TD
-0.0004 Tc
-0.0635 Tw
(\(86 patient-years\). Table II shows localization of throm-)Tj
T*
-0.0001 Tc
0.1062 Tw
(bosis in both groups of patients. In the patient group)Tj
0 -1.4467 TD
0 Tc
0.0417 Tw
(the INR value was maintained within 2.03.0 for 70%)Tj
0 -1.4433 TD
-0.0001 Tc
0.0223 Tw
(of observation time \(for 19% of observation time INR)Tj
T*
0.0001 Tc
-0.0179 Tw
(was < 2.0 and for 11% it )Tj
11.4614 0 TD
[(was >3.0\). )]TJ
5.423 0 TD
0.0092 Tc
-0.0185 Tw
(In the reference)Tj
-16.8843 -1.4467 TD
0.0086 Tc
-0.0694 Tw
(group the INR value was maintained within 2.03.0 for)Tj
0 -1.4433 TD
0.0062 Tc
(68% of observation time \(for 17% of observation time)Tj
T*
0.0101 Tc
0.061 Tw
(INR was < 2.0 and for 15% it was >3.0\). In the fo-)Tj
26.6167 50.5533 TD
0.0045 Tc
0.1389 Tw
(cych acenokumarol, zmierzono czas protrombinowy)Tj
0 -1.4433 TD
0.0016 Tc
(przy uyciu polskiej tromboplastyny oraz za pomoc)Tj
T*
-0.0016 Tc
-0.0689 Tw
(tromboplastyny zagranicznej Thromborel S \(Dade Beh-)Tj
0 -1.4467 TD
-0.0005 Tc
0.1206 Tw
(ring, Marburg, Niemcy\), ktr uznaje si za niewra-)Tj
0 -1.4433 TD
-0.0002 Tc
0.0473 Tw
(liw na LA [11]. Nastpnie obliczono warto INR dla)Tj
T*
-0.0007 Tc
-0.0361 Tw
(kadego pomiaru czasu protrombinowego, korzystajc)Tj
0 -1.4467 TD
-0.0004 Tc
0.0185 Tw
(z tabel przelicze dostarczonych przez producentw i)Tj
0 -1.4433 TD
-0.0001 Tc
-0.0111 Tw
(porwnano uzyskane wyniki.)Tj
1.89 -1.4433 TD
-0.0101 Tc
0.0639 Tw
(Czas protrombinowy i F1+2 oznaczano w osoczu)Tj
-1.89 -1.4467 TD
0.0007 Tw
[(uzyskanym z krwi pobieranej do 5-)-9.1(mililitrowych )-5.3(prob-)]TJ
0 -1.4433 TD
-0.0103 Tc
0.0431 Tw
(wek zawierajcych 3,2-procentowy cytrynian trjsodo-)Tj
T*
-0.0101 Tc
0.05 Tw
(wy. Krew do oznacze F1+2 bya wirowana 1700 )Tj
/F6 1 Tf
22.4667 0 TD
0 Tc
0 Tw
()Tj
/F2 1 Tf
0.8233 0 TD
0.0387 Tc
( g)Tj
-23.29 -1.4467 TD
-0.0106 Tc
0.0064 Tw
[(przez 15 min w temperaturze pokojowej, a odcignite)]TJ
0 -1.4433 TD
-0.0201 Tc
-0.0689 Tw
(osocze powtrnie poddawano wirowaniu 1700 )Tj
/F6 1 Tf
20.0467 0 TD
0 Tc
0 Tw
()Tj
/F2 1 Tf
0.81 0 TD
-0.0217 Tc
-0.0695 Tw
[( g przez)]TJ
-20.8567 -1.4433 TD
-0.01 Tc
-0.0472 Tw
(5 min. Do momentu wykonania badania ubogopytkowe)Tj
0 -1.4467 TD
-0.0107 Tc
0.0945 Tw
(osocze przechowywano w temperaturze 70C. Frag-)Tj
0 -1.4433 TD
-0.01 Tc
0.0022 Tw
(ment protrombiny 1+2 oznaczano metod immunoen-)Tj
T*
-0.0033 Tc
0.1389 Tw
(zymatyczn \(Dade Behring\). Za wartoci prawidowe)Tj
0 -1.4467 TD
-0.0101 Tc
-0.0398 Tw
(uznawano stenie F1+2 wynoszce poniej 1,1 nmol/l.)Tj
/F4 1 Tf
11 0 0 11 354.75 474.515 Tm
0.0024 Tc
0.0318 Tw
(Analiza statystyczna)Tj
/F2 1 Tf
9 0 0 9 318.9 461.015 Tm
0.0095 Tc
0.1139 Tw
(rednie wartoci INR w dwch grupach pacjen-)Tj
-1.89 -1.4433 TD
0.004 Tc
-0.0689 Tw
(tw porwnano za pomoc testu U-Manna-Whitneya.)Tj
T*
-0.0101 Tc
-0.0241 Tw
(Rnice uznawano za znamienne dla poziomu istotnoci)Tj
0 -1.4467 TD
0.0105 Tc
0 Tw
(p < 0,05.)Tj
/F4 1 Tf
11 0 0 11 391.65 396.515 Tm
0.0031 Tc
(Wyniki)Tj
/F2 1 Tf
9 0 0 9 318.9 383.015 Tm
0.0196 Tc
0.0849 Tw
(W tabeli I przedstawiono zaleno INR od ro-)Tj
-1.89 -1.4433 TD
0.0158 Tc
-0.0691 Tw
[(dzaju uytej tromboplastyny w grupie pacjentw z LA)]TJ
T*
0.0198 Tc
0.0373 Tw
(i w grupie osb z wrodzon trombofili, otrzymuj-)Tj
0 -1.4467 TD
0.0259 Tc
0.1389 Tw
(cych acenokumarol w ramach wtrnej profilaktyki)Tj
0 -1.4433 TD
0.0195 Tc
(przeciwzakrzepowej. Rnice pomidzy wartocia-)Tj
T*
-0.0278 Tw
(mi INR w obrbie kadej z badanych grup byy staty-)Tj
0 -1.4467 TD
0.0201 Tc
-0.0167 Tw
(stycznie nieistotne.)Tj
1.5733 -1.4433 TD
0.0086 Tc
-0.0686 Tw
[(Przebieg wtrnej profilaktyki przeciwzakrzepowej)]TJ
-1.5733 -1.4433 TD
0.0233 Tc
0.1676 Tw
(z zastosowaniem OA obserwowano przez 38 lat)Tj
/F4 1 Tf
8.3 0 0 9 63.9 249.875 Tm
-0.0042 Tc
-0.009 Tw
(Table I. )Tj
/F2 1 Tf
3.9687 0 TD
0.003 Tc
-0.0109 Tw
(Relationship between the INR and the kind of thromboplastin reagent used in the lupus anticoagulant group of pa-)Tj
-3.9687 -1.4067 TD
0.0032 Tc
-0.0177 Tw
(tients and in the group with inherited thrombophilia receiving acenocoumarol for prevention of recurrent thrombosis)Tj
/F4 1 Tf
0 -1.8167 TD
-0.0033 Tc
-0.0061 Tw
(Tabela I.)Tj
/F2 1 Tf
4.2542 0 TD
0.0029 Tc
-0.0116 Tw
[( Zaleno INR od rodzaju uytej tromboplastyny w grupie pacjentw z antykoagulantem toczniowym i w grupie)]TJ
-4.2542 -1.5 TD
0.0028 Tc
-0.0175 Tw
(osb z wrodzon trombofili, przyjmujacych acenocoumarol w ramach wtrnej profilaktyki przeciwzakrzepowej)Tj
ET
63.9 191.405 m
520.29 191.405 l
S
BT
/F4 1 Tf
7.35 0 0 8 63.9 181.625 Tm
0.0035 Tc
0.0008 Tw
[(Groups of patients \(n\))-17812.8(INR value \(x SD\))-16861.8(p)]TJ
0 -1.2 TD
0.0047 Tc
0.0068 Tw
[(Grupy pacjentw)-21795.3(Warto INR)]TJ
ET
63.9 163.055 m
520.29 163.055 l
S
BT
7.35 0 0 8 225.75 153.275 Tm
0.0037 Tc
0.0091 Tw
[(Polish rabbit brain)-6188.1(Thromborel S)]TJ
-1.3265 -1.2 TD
0.004 Tc
0.0068 Tw
(thromboplastin reagent)Tj
0.2245 -1.2 TD
0.0046 Tc
0 Tw
(Polska tromboplastyna)Tj
ET
63.9 120.365 m
520.29 120.365 l
S
BT
7.35 0 0 8 224.61 124.475 Tm
0.0043 Tc
(mzgw krliczych)Tj
/F2 1 Tf
-21.8653 -2.3925 TD
-0.0009 Tc
-0.0237 Tw
[(LA )-6.9(\(n )-6.9(= )-6.9(20\))-18335.6(2.52 \( 0.75\))-8278.4(2.54 \( 0.63\))-10698.9(0.60)]TJ
0 -1.9125 TD
-0.0002 Tc
-0.0204 Tw
(Inherited thrombophilia \(n = 20\))Tj
ET
0.51 w
63.9 75.59 m
520.29 75.59 l
S
BT
7.35 0 0 8 63.9 80.435 Tm
-0.0011 Tc
-0.0235 Tw
[(Wrodzona )-10.3(trombofilia)-13837.8(3.07 \( 1.18\))-8278.6(2.91 \( 1.06\))-10699.1(0.66)]TJ
/F7 1 Tf
6.45 0 0 7 63.9 66.875 Tm
-0.0008 Tc
-0.0078 Tw
(INR \()Tj
6.45 0 1.3545 7 77.4 66.875 Tm
0.0011 Tc
-0.0116 Tw
(international normalized ratio)Tj
6.45 0 0 7 154.8 66.875 Tm
0.0004 Tc
-0.0103 Tw
(\) midzynarodowy wspczynnik znormalizowany; x \()Tj
6.45 0 1.3545 7 305.31 66.875 Tm
0.0014 Tc
-0.0155 Tw
(mean value)Tj
6.45 0 0 7 336 66.875 Tm
0.0008 Tc
-0.0109 Tw
(\) warto rednia; SD \()Tj
6.45 0 1.3545 7 406.41 66.875 Tm
0.0002 Tc
-0.0078 Tw
(standard deviation)Tj
6.45 0 0 7 455.85 66.875 Tm
0.0005 Tc
-0.0129 Tw
(\) odchylenie stan-)Tj
-60.7674 -1.2 TD
0 Tc
-0.0232 Tw
(dardowe; LA \()Tj
6.45 0 1.3545 7 101.49 58.475 Tm
0.0014 Tc
(lupus anticoagulant)Tj
6.45 0 0 7 153.66 58.475 Tm
0.0006 Tc
-0.0259 Tw
(\) antykoagulant toczniowy)Tj
ET
1 g
1 G
1000 M
62.605 166.82 144.64 -7.44 re
B*
406.755 166.52 115.74 -7.44 re
B*
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BT
/F2 1 Tf
10 0 0 10 507.54 40.175 Tm
0 g
/GS2 gs
0.009 Tc
0 Tw
(19)Tj
ET
0 G
0 J 0 j 0.24 w 10 M []0 d
1 i
62.34 768.395 m
518.76 768.395 l
S
BT
/F4 1 Tf
8 0 0 8 316.8 772.535 Tm
0.0075 Tw
[(Prevention of thrombosis in APS patients)-6(,)9.2( )]TJ
/F2 1 Tf
21.4125 0 TD
0.0011 Tc
0 Tw
(Windyga)Tj
-28.8563 -91.3463 TD
0.0094 Tc
(www.angiologia.pl)Tj
9 0 0 9 62.34 201.035 Tm
0.0238 Tc
0.2096 Tw
(llow-up period only one recurrence of deep vein)Tj
0 -1.4467 TD
0.0096 Tc
0.0097 Tw
[(thrombosis in one APS patient was observed \(the pa-)]TJ
0 -1.4433 TD
0.0098 Tc
-0.0333 Tw
(tient decided to stop taking acenocoumarol\). In 3 APS)Tj
T*
0.0178 Tw
(patients mild bleeding complications occurred, which)Tj
0 -1.4467 TD
0.01 Tc
0.1341 Tw
(did not require the interruption of oral anticoa)Tj
21.98 0 TD
-0.0003 Tc
0 Tw
(gula-)Tj
-21.98 -1.4433 TD
0.0001 Tc
0.0514 Tw
(tion. In the group of patients with inherited thrombo-)Tj
T*
-0.0003 Tc
0.0898 Tw
(philia neither recurrences of thrombosis nor bleeding)Tj
0 -1.4467 TD
-0.0005 Tc
0.0028 Tw
(complications were observed.)Tj
1.5733 -1.4433 TD
-0.0004 Tc
-0.021 Tw
(Figure 1 shows the levels of F1+2 measured in pla-)Tj
-1.5733 -1.4433 TD
-0.0643 Tw
[(sma samples of 20 patients receiving oral anticoagulants)]TJ
0 -1.4467 TD
0 Tc
0.1095 Tw
(\(INR 2.03.0\). Both in 10 APS patients and in 10 pa-)Tj
26.6167 50.5567 TD
-0.0003 Tc
0.0361 Tw
[(u)-10.9( )-8.1(2)-10.9(1)-13.6( osb z zespoem antyfosfolipidowym \(95 pacjen-)]TJ
0 -1.4433 TD
-0.0001 Tc
-0.0094 Tw
(tolat\) i przez 25 lat u 21 osb z wrodzon trombofili)Tj
0 -1.4467 TD
-0.0085 Tc
-0.0695 Tw
(\(86 pacjentolat\). Lokalizacj zakrzepicy u pacjentw obu)Tj
0 -1.4433 TD
-0.0005 Tc
-0.0426 Tw
(grup przedstawiono w tabeli II. U osb z grupy badanej)Tj
T*
-0.0051 Tc
0 Tw
(warto )Tj
3.7233 0 TD
-0.0146 Tc
-0.0687 Tw
[(INR utrzymywaa si w przedziale 2,0)2.1(3,0 przez)]TJ
-3.7233 -1.4467 TD
-0.0056 Tc
0.1388 Tw
(70% czasu obserwacji. Warto INR mniejsz od 2,0)Tj
0 -1.4433 TD
-0.0354 Tc
-0.0694 Tw
(i wiksz ni 3,0 zanotowano odpowiednio w 19% i w 11%)Tj
T*
-0.0103 Tc
0.0436 Tw
[(cakowitego czasu obserwacji. U osb z grupy kontrol-)]TJ
0 -1.4467 TD
-0.0106 Tc
-0.0204 Tw
(nej przez 68% czasu obserwacji INR zawiera si w gra-)Tj
0 -1.4433 TD
-0.0083 Tc
0.1389 Tw
[(nicach 2,0)-5()-9.3(3,0. Warto INR poniej 2,0 stwierdzono)]TJ
T*
-0.0102 Tc
0.0802 Tw
(w 17%, a INR powyej 3,0 w 15% cakowitego czasu)Tj
0 -1.4467 TD
0.0008 Tc
0.1389 Tw
(obserwacji. W okresie obserwacji nawrt zakrzepicy)Tj
0 -1.4433 TD
0.0002 Tc
(w yach gbokich koczyny dolnej zaobserwowano)Tj
T*
-0.0104 Tc
-0.0139 Tw
(u 1 pacjenta z APS, ktry samowolnie przesta przyjmo-)Tj
0 -1.4467 TD
-0.0382 Tw
(wa acenokumarol. U 3 chorych z APS zanotowano nie-)Tj
0 -1.4433 TD
-0.0194 Tc
-0.0667 Tw
[(wielkie powikania krwotoczne, )]TJ
13.5233 0 TD
-0.0207 Tc
(niewymaga)Tj
4.76 0 TD
-0.0122 Tc
0 Tw
[(jce)-8.9( )]TJ
1.8743 0 TD
-0.0204 Tc
(przerwa-)Tj
-20.1577 -1.4433 TD
-0.0107 Tc
-0.0567 Tw
(nia leczenia przeciwzakrzepowego. W grupie pacjentw)Tj
0 -1.4467 TD
-0.0101 Tc
0.0527 Tw
(z wrodzon trombofili nie stwierdzono nawrotw za-)Tj
0 -1.4433 TD
-0.0103 Tc
-0.0074 Tw
(krzepicy ani powika krwotocznych.)Tj
1.89 -1.4433 TD
-0.0203 Tc
-0.0574 Tw
(Na rycinie 1 przedstawiono wyniki pomiarw zawar-)Tj
-1.89 -1.4467 TD
-0.02 Tc
-0.0587 Tw
(toci F1+2 w osoczu 20 pacjentw otrzymujcych doust-)Tj
0 -1.4433 TD
0.0905 Tw
(ny antykoagulant \(INR 2,03,0\). Zarwno u 10 chorych)Tj
T*
-0.0003 Tc
0.0685 Tw
[(z)18.4( )21.5(APS, jak i u 10 osb z wrodzon trombofili zawar-)]TJ
0 -1.4467 TD
0.0002 Tc
0 Tw
[(to )]TJ
2.0787 0 TD
-0.0203 Tc
-0.018 Tw
(F1+2 cay czas utrzymywaa si w granicach normy.)Tj
/F4 1 Tf
11 0 0 11 386.25 201.515 Tm
0.0042 Tc
0 Tw
(Dyskusja)Tj
/F2 1 Tf
9 0 0 9 316.05 188.015 Tm
-0.0002 Tc
0.0056 Tw
(Dotychczas polskej tromboplastyny mzgw krli-)Tj
-1.5733 -1.4433 TD
0.0136 Tc
0.1978 Tw
(czych \(Biomed, Wytwrnia Surowic i Szczepionek,)Tj
T*
-0.0007 Tc
-0.0333 Tw
(Warszawa\) nie badano pod ktem wraliwoci na anty-)Tj
0 -1.4467 TD
-0.0003 Tc
0.0296 Tw
(koagulant toczniowy. W niniejszej pracy wykazano, e)Tj
0 -1.4433 TD
-0.0005 Tc
0.049 Tw
(tromboplastyna ta, podobnie jak Thromborel S \(Dade)Tj
T*
0.0135 Tc
0.1926 Tw
(Behring, Marburg, Niemcy\) jest niewraliwa na LA)Tj
0 -1.4467 TD
-0.0003 Tc
0.0436 Tw
(i mona j stosowa do oznacze czasu protrombino-)Tj
0 -1.4433 TD
-0.0002 Tc
-0.0011 Tw
(wego u pacjentw z antykoagulantem toczniowym.)Tj
1.5733 -1.4433 TD
0.0175 Tc
0.1365 Tw
(Leczenie ostrej zakrzepicy u chorych z APS nie)Tj
-1.5733 -1.4467 TD
0.0178 Tc
-0.0341 Tw
(rni si od ustalonych standardw [12]. Ze wzgldu)Tj
/F4 1 Tf
8.3 0 0 9 62.34 733.775 Tm
-0.0035 Tc
-0.006 Tw
(Table II.)Tj
/F2 1 Tf
4.0373 0 TD
0.0028 Tc
-0.0096 Tw
[( Localization of thrombosis in the antiphospholipid antibody syndrome group of patients and in the group with in-)]TJ
-4.0373 -1.5 TD
0.0033 Tc
-0.0421 Tw
(herited thrombophilia)Tj
/F4 1 Tf
T*
-0.0034 Tc
-0.006 Tw
(Tabela II.)Tj
/F2 1 Tf
4.6048 0 TD
0.0026 Tc
-0.009 Tw
[( Lokalizacja zakrzepicy u pacjentw z APS i u pacjentw z wrodzon trombofili)]TJ
ET
62.34 695.285 m
518.76 695.285 l
S
BT
/F4 1 Tf
7.35 0 0 8 62.34 685.535 Tm
0.0038 Tc
0.0048 Tw
[(Localization of thrombosis)-10563.5(Patients with APS)-8081.9(Patients with inherited thrombophilia)]TJ
0 -1.2 TD
0.0036 Tc
0.0042 Tw
[(Umiejscowienie )4.5(zakrzepicy)-11094.4(Pacjenci z APS)-10310.7(Pacjenci z wrodzon trombofili)]TJ
ET
62.34 662.195 m
518.76 662.195 l
S
BT
7.35 0 0 8 256.95 666.335 Tm
0.0039 Tc
0.0034 Tw
[(n = 21)-18616.5(n = 21)]TJ
/F2 1 Tf
-26.4776 -2.04 TD
-0.0017 Tc
-0.0272 Tw
[(Venous)-22785.4(17 \(81%\))-17360.9(20 )6.5(\(95.2%\))]TJ
0 -1.2 TD
-0.0031 Tc
0 Tw
[()-5.1(ylna)]TJ
0 -1.5563 TD
-0.0003 Tc
-0.0343 Tw
[(Arterial)-22853.4(2 \(9.5%\))-19747.2()]TJ
0 -1.2 TD
-0.002 Tc
0 Tw
(Ttnicza)Tj
0 -1.5562 TD
0.0003 Tc
-0.0197 Tw
[(Venous and arterial)-17652.8(2 )15.2(\(9.5%\))-18052.8(1 )15.2(\(4.8%\))]TJ
0 -1.2 TD
0.0006 Tc
-0.0171 Tw
(ylna i ttnicza)Tj
0 -1.5563 TD
-0.0007 Tc
-0.0344 Tw
[(Pulmonary )-7.5(embolism)-16600.7(7 \(33.3%\))-17502.7(3 \(14.3%\))]TJ
ET
0.51 w
62.34 569.42 m
518.76 569.42 l
S
BT
7.35 0 0 8 62.34 574.265 Tm
0.0005 Tc
-0.0239 Tw
(Zator ttnicy pucnej)Tj
/F7 1 Tf
6.45 0 0 7 62.34 560.735 Tm
0.0012 Tc
-0.031 Tw
(APS \()Tj
6.45 0 1.3545 7 77.4 560.735 Tm
0.0004 Tc
-0.0349 Tw
(antiphospholipid antibody syndrome)Tj
6.45 0 0 7 173.91 560.735 Tm
-0.0001 Tc
-0.0361 Tw
(\) zesp antyfosfolipidowy)Tj
/F4 1 Tf
8 0 0 8 62.34 336.815 Tm
-0.0008 Tc
0 Tw
(Figure 1. )Tj
/F2 1 Tf
4.62 0 TD
-0.0005 Tc
0.001 Tw
(Prothrombin fragment 1+2 levels \(F1+2\) in plas-)Tj
-4.62 -1.2 TD
-0.0007 Tc
0 Tw
(ma samples of 10 patients with antiphospholipid antibody)Tj
T*
-0.0002 Tc
(syndrome and in 10 with inherited thrombophilia during)Tj
T*
-0.0005 Tc
0.0012 Tw
(acenocoumarol \(INR 2.03.0\) treatment. Horizontal broken)Tj
T*
-0.0003 Tc
0 Tw
(line represents the upper limit of the normal range. Within)Tj
T*
-0.0005 Tc
(16 weeks, 4 blood samples from each patient were taken)Tj
/F4 1 Tf
0 -1.5563 TD
0 Tc
(Rycina 1.)Tj
/F2 1 Tf
4.425 0 TD
-0.0007 Tc
( Zawarto fragmentu protrombiny 1+2 \(F1+2\))Tj
-4.425 -1.2 TD
-0.0009 Tc
(w osoczu 10 pacjentw z zespoem antyfosfolipidowym i u)Tj
T*
-0.001 Tc
(10 osb z wrodzon trombofili w czasie stosowania aceno-)Tj
T*
-0.0006 Tc
0.001 Tw
(coumarolu \(INR 2,03,0\). Przerywana linia oznacza grn)Tj
T*
-0.0009 Tc
0 Tw
(granic wartoci prawidowych. U kadego pacjenta wyko-)Tj
T*
-0.0004 Tc
(nano 4 oznaczenia w okresie 16 tygodni)Tj
ET
/EmbeddedDocument /MC2 BDC
1 g
0.5 w 2.613 M
109.85 413.923 m
110.786 413.923 111.55 413.159 111.55 412.222 c
111.55 411.285 110.786 410.522 109.85 410.522 c
108.913 410.522 108.148 411.285 108.148 412.222 c
108.148 413.159 108.913 413.923 109.85 413.923 c
b*
0 g
69.083 425.445 m
63.066 425.445 l
63.067 428.277 l
63.675 428.277 l
63.675 426.117 l
65.643 426.117 l
65.643 428.117 l
66.243 428.117 l
66.243 426.117 l
69.083 426.117 l
69.083 425.445 l
f
69.083 430.269 m
64.707 430.269 l
64.707 428.989 l
64.195 428.989 l
64.195 429.431 64.133 429.751 64.011 429.949 c
63.845 430.215 63.536 430.37 63.082 430.413 c
63.083 430.925 l
69.083 430.924 l
69.083 430.269 l
f
67.331 432.74 m
66.771 432.74 l
66.771 434.116 l
65.035 434.116 l
65.035 434.66 l
66.771 434.66 l
66.771 436.052 l
67.331 436.052 l
67.331 434.66 l
69.083 434.66 l
69.083 434.116 l
67.331 434.116 l
67.331 432.74 l
f
69.083 436.756 m
68.726 436.756 68.417 436.79 68.155 436.86 c
67.808 436.95 67.534 437.102 67.331 437.316 c
67.097 437.566 66.814 437.86 66.483 438.196 c
66.233 438.451 66.017 438.666 65.835 438.84 c
65.654 439.013 65.451 439.126 65.227 439.179 c
65.099 439.211 64.904 439.228 64.643 439.228 c
64.334 439.228 64.095 439.151 63.927 438.999 c
63.759 438.848 63.675 438.635 63.675 438.364 c
63.675 438.049 63.774 437.82 63.971 437.676 c
64.195 437.51 64.56 437.428 65.067 437.428 c
65.072 437.428 65.094 437.428 65.131 437.428 c
65.131 436.804 l
64.851 436.796 l
64.264 436.796 63.823 436.933 63.527 437.208 c
63.231 437.482 63.083 437.884 63.083 438.412 c
63.083 438.918 63.248 439.302 63.579 439.563 c
63.872 439.793 64.254 439.907 64.723 439.907 c
65.118 439.907 65.459 439.835 65.747 439.69 c
65.95 439.587 66.15 439.435 66.347 439.231 c
66.512 439.059 66.675 438.887 66.835 438.715 c
67.027 438.512 67.209 438.307 67.379 438.103 c
67.614 437.836 67.79 437.661 67.907 437.581 c
68.062 437.478 68.257 437.428 68.491 437.428 c
68.491 439.971 l
69.083 439.971 l
69.083 436.756 l
f
70.756 443.195 m
63.083 443.195 l
63.083 444.595 l
63.555 444.595 l
63.555 443.819 l
70.251 443.819 l
70.252 444.595 l
70.756 444.595 l
70.756 443.195 l
f
69.084 445.627 m
64.627 445.627 l
64.627 446.267 l
65.131 446.267 l
65.094 446.272 65.019 446.336 64.907 446.459 c
64.641 446.752 64.507 447.037 64.507 447.315 c
64.507 447.704 64.606 447.997 64.803 448.194 c
65.001 448.392 65.313 448.49 65.739 448.49 c
69.084 448.49 l
69.084 447.85 l
66.051 447.851 l
65.699 447.851 65.459 447.821 65.331 447.762 c
65.134 447.672 65.035 447.488 65.035 447.211 c
65.035 446.944 65.121 446.72 65.291 446.539 c
65.462 446.357 65.705 446.267 66.019 446.267 c
69.084 446.267 l
69.084 445.627 l
f
69.084 449.658 m
64.627 449.658 l
64.627 450.266 l
65.212 450.266 l
64.993 450.394 64.821 450.558 64.695 450.758 c
64.57 450.958 64.507 451.159 64.507 451.362 c
64.507 451.586 64.565 451.783 64.68 451.954 c
64.794 452.125 64.977 452.271 65.228 452.394 c
65.004 452.543 64.828 452.714 64.699 452.906 c
64.572 453.098 64.508 453.316 64.508 453.562 c
64.508 454.01 64.665 454.324 64.98 454.505 c
65.172 454.618 65.414 454.673 65.708 454.673 c
69.084 454.673 l
69.084 454.05 l
65.788 454.05 l
65.59 454.05 65.438 454.02 65.332 453.962 c
65.145 453.86 65.052 453.671 65.052 453.394 c
65.052 453.122 65.126 452.908 65.275 452.754 c
65.446 452.578 65.705 452.49 66.052 452.49 c
69.084 452.49 l
69.084 451.85 l
65.956 451.85 l
65.646 451.85 65.425 451.81 65.292 451.729 c
65.131 451.631 65.051 451.459 65.051 451.211 c
65.051 450.963 65.116 450.759 65.243 450.598 c
65.419 450.377 65.689 450.266 66.052 450.266 c
69.084 450.266 l
69.084 449.658 l
f
66.788 455.673 m
66.11 455.673 65.58 455.785 65.196 456.009 c
64.748 456.271 64.524 456.678 64.524 457.233 c
64.524 457.814 64.718 458.236 65.108 458.497 c
65.47 458.737 66.036 458.857 66.804 458.857 c
67.556 458.857 68.129 458.747 68.524 458.529 c
68.983 458.278 69.212 457.873 69.212 457.313 c
69.212 456.732 68.975 456.302 68.5 456.025 c
68.095 455.79 67.524 455.673 66.788 455.673 c
h
66.804 456.329 m
67.364 456.329 67.769 456.372 68.02 456.457 c
68.447 456.601 68.66 456.881 68.66 457.297 c
68.66 457.686 68.441 457.948 68.004 458.081 c
67.748 458.161 67.369 458.201 66.868 458.201 c
66.334 458.201 65.934 458.156 65.668 458.065 c
65.246 457.921 65.036 457.654 65.036 457.265 c
65.036 456.87 65.26 456.601 65.708 456.457 c
65.969 456.372 66.334 456.329 66.804 456.329 c
f
69.084 459.841 m
63.068 459.841 l
63.068 460.465 l
69.084 460.464 l
69.084 459.841 l
f
69.3 460.937 m
63.084 462.888 l
63.084 463.376 l
69.3 461.44 l
69.3 460.937 l
f
63.068 464.464 6.016 -0.624 re
f
70.252 466.28 m
63.556 466.28 l
63.556 465.504 l
63.084 465.504 l
63.084 466.904 l
70.756 466.904 l
70.756 465.504 l
70.252 465.504 l
70.252 466.28 l
f
76.95 527.3 m
76.95 531.675 l
75.67 531.675 l
75.67 532.188 l
76.113 532.188 76.433 532.249 76.63 532.372 c
76.897 532.537 77.052 532.846 77.094 533.299 c
77.606 533.299 l
77.606 527.3 l
76.95 527.3 l
f
79.719 528.1 0.736 -0.8 re
f
81.439 527.3 m
81.439 527.658 81.473 527.967 81.543 528.228 c
81.633 528.575 81.785 528.849 81.999 529.052 c
82.25 529.286 82.543 529.569 82.879 529.9 c
83.135 530.15 83.349 530.366 83.523 530.548 c
83.696 530.729 83.81 530.932 83.863 531.156 c
83.895 531.284 83.911 531.478 83.911 531.74 c
83.911 532.049 83.835 532.287 83.683 532.455 c
83.531 532.624 83.319 532.707 83.047 532.707 c
82.732 532.707 82.503 532.609 82.359 532.411 c
82.193 532.188 82.111 531.822 82.111 531.315 c
82.111 531.31 82.111 531.289 82.111 531.252 c
81.487 531.252 l
81.479 531.531 l
81.479 532.118 81.616 532.559 81.891 532.855 c
82.165 533.151 82.567 533.299 83.095 533.299 c
83.601 533.299 83.986 533.134 84.247 532.804 c
84.476 532.51 84.591 532.129 84.591 531.66 c
84.591 531.265 84.519 530.924 84.374 530.636 c
84.271 530.433 84.119 530.233 83.915 530.036 c
83.743 529.871 83.571 529.708 83.399 529.548 c
83.195 529.356 82.991 529.174 82.787 529.004 c
82.519 528.769 82.344 528.593 82.264 528.476 c
82.161 528.321 82.111 528.127 82.111 527.892 c
84.655 527.892 l
84.655 527.3 l
81.439 527.3 l
f
76.95 503.092 m
76.95 507.468 l
75.67 507.468 l
75.67 507.98 l
76.113 507.98 76.433 508.041 76.63 508.164 c
76.897 508.329 77.052 508.638 77.094 509.092 c
77.606 509.092 l
77.606 503.092 l
76.95 503.092 l
f
79.719 503.892 0.736 -0.8 re
f
81.455 505.98 m
81.455 506.567 81.473 507.004 81.511 507.292 c
81.58 507.825 81.721 508.241 81.935 508.54 c
82.201 508.907 82.583 509.092 83.079 509.092 c
83.58 509.092 83.964 508.918 84.231 508.572 c
84.444 508.294 84.586 507.889 84.655 507.356 c
84.698 507.036 84.719 506.577 84.719 505.98 c
84.719 505.415 84.7 504.993 84.663 504.716 c
84.594 504.193 84.452 503.791 84.239 503.508 c
83.967 503.146 83.58 502.964 83.079 502.964 c
82.38 502.964 81.908 503.34 81.663 504.092 c
81.524 504.519 81.455 505.148 81.455 505.98 c
h
82.127 505.98 m
82.127 505.732 l
82.127 504.793 82.207 504.193 82.367 503.932 c
82.511 503.697 82.748 503.58 83.079 503.58 c
83.479 503.58 83.751 503.833 83.895 504.34 c
83.986 504.665 84.031 505.153 84.031 505.804 c
84.031 505.98 l
84.031 506.828 83.986 507.42 83.895 507.756 c
83.762 508.252 83.489 508.5 83.079 508.5 c
82.668 508.5 82.396 508.26 82.263 507.78 c
82.172 507.454 82.127 506.855 82.127 505.98 c
f
75.454 481.772 m
75.454 482.359 75.473 482.796 75.51 483.084 c
75.58 483.617 75.721 484.033 75.934 484.332 c
76.201 484.7 76.582 484.884 77.078 484.884 c
77.58 484.884 77.964 484.71 78.23 484.364 c
78.444 484.087 78.585 483.681 78.654 483.148 c
78.697 482.828 78.718 482.369 78.718 481.772 c
78.718 481.207 78.7 480.785 78.662 480.508 c
78.593 479.986 78.452 479.583 78.238 479.301 c
77.966 478.938 77.58 478.756 77.078 478.756 c
76.38 478.756 75.908 479.133 75.662 479.884 c
75.524 480.311 75.454 480.94 75.454 481.772 c
h
76.126 481.772 m
76.126 481.524 l
76.126 480.586 76.206 479.986 76.366 479.724 c
76.51 479.49 76.748 479.373 77.078 479.373 c
77.478 479.373 77.75 479.626 77.894 480.132 c
77.985 480.458 78.03 480.946 78.03 481.596 c
78.03 481.772 l
78.03 482.62 77.985 483.212 77.894 483.548 c
77.761 484.044 77.489 484.292 77.078 484.292 c
76.668 484.292 76.396 484.052 76.262 483.572 c
76.172 483.246 76.126 482.647 76.126 481.772 c
f
79.719 479.684 0.736 -0.8 re
f
82.607 482.132 m
82.324 482.185 82.111 482.284 81.967 482.428 c
81.748 482.641 81.639 482.98 81.639 483.444 c
81.639 483.822 81.743 484.14 81.951 484.396 c
82.217 484.721 82.62 484.884 83.159 484.884 c
83.676 484.884 84.052 484.721 84.287 484.396 c
84.463 484.156 84.551 483.849 84.551 483.476 c
84.551 483.145 84.503 482.884 84.407 482.692 c
84.263 482.409 84.001 482.217 83.623 482.116 c
83.943 482.068 84.194 481.94 84.375 481.732 c
84.604 481.476 84.719 481.116 84.719 480.652 c
84.719 480.162 84.615 479.754 84.407 479.428 c
84.124 478.991 83.687 478.773 83.095 478.773 c
82.599 478.773 82.21 478.911 81.927 479.188 c
81.612 479.498 81.455 479.948 81.455 480.54 c
81.455 480.972 81.555 481.328 81.755 481.608 c
81.955 481.888 82.239 482.063 82.607 482.132 c
h
82.327 483.276 m
82.327 482.983 82.401 482.759 82.551 482.604 c
82.684 482.465 82.86 482.396 83.079 482.396 c
83.367 482.396 83.569 482.477 83.687 482.64 c
83.804 482.803 83.863 483.041 83.863 483.356 c
83.863 483.66 83.81 483.886 83.703 484.036 c
83.58 484.206 83.383 484.292 83.111 484.292 c
82.807 484.292 82.593 484.196 82.471 484.004 c
82.375 483.854 82.327 483.612 82.327 483.276 c
h
82.143 480.588 m
82.143 480.215 82.221 479.919 82.379 479.7 c
82.536 479.482 82.78 479.373 83.111 479.373 c
83.42 479.373 83.651 479.487 83.803 479.716 c
83.955 479.946 84.031 480.268 84.031 480.684 c
84.031 480.967 83.967 481.209 83.839 481.412 c
83.673 481.673 83.431 481.804 83.111 481.804 c
82.466 481.804 82.143 481.399 82.143 480.588 c
f
75.454 457.564 m
75.454 458.151 75.473 458.588 75.51 458.876 c
75.58 459.409 75.721 459.825 75.934 460.124 c
76.201 460.492 76.582 460.676 77.078 460.676 c
77.58 460.676 77.964 460.503 78.23 460.156 c
78.444 459.879 78.585 459.473 78.654 458.94 c
78.697 458.62 78.718 458.161 78.718 457.564 c
78.718 456.999 78.7 456.578 78.662 456.3 c
78.593 455.778 78.452 455.375 78.238 455.093 c
77.966 454.73 77.58 454.549 77.078 454.549 c
76.38 454.549 75.908 454.925 75.662 455.677 c
75.524 456.103 75.454 456.732 75.454 457.564 c
h
76.126 457.564 m
76.126 457.316 l
76.126 456.378 76.206 455.778 76.366 455.516 c
76.51 455.282 76.748 455.165 77.078 455.165 c
77.478 455.165 77.75 455.418 77.894 455.925 c
77.985 456.25 78.03 456.738 78.03 457.388 c
78.03 457.564 l
78.03 458.412 77.985 459.004 77.894 459.34 c
77.761 459.836 77.489 460.084 77.078 460.084 c
76.668 460.084 76.396 459.844 76.262 459.364 c
76.172 459.039 76.126 458.439 76.126 457.564 c
f
79.719 455.476 0.736 -0.8 re
f
81.407 457.332 m
81.407 457.676 l
81.407 458.124 81.439 458.524 81.503 458.876 c
81.597 459.404 81.757 459.815 81.98 460.108 c
82.267 460.487 82.656 460.676 83.15 460.676 c
83.569 460.676 83.902 460.572 84.145 460.364 c
84.432 460.118 84.575 459.748 84.575 459.252 c
83.903 459.252 l
83.903 459.519 83.85 459.724 83.744 459.868 c
83.639 460.012 83.47 460.084 83.236 460.084 c
82.787 460.084 82.464 459.793 82.269 459.212 c
82.143 458.839 82.079 458.404 82.079 457.908 c
82.079 457.74 l
82.185 457.97 82.344 458.147 82.555 458.272 c
82.765 458.397 82.996 458.46 83.247 458.46 c
83.652 458.46 83.988 458.308 84.255 458.004 c
84.564 457.652 84.719 457.162 84.719 456.533 c
84.719 456.063 84.607 455.647 84.383 455.285 c
84.079 454.794 83.639 454.549 83.063 454.549 c
82.466 454.549 82.033 454.794 81.767 455.285 c
81.527 455.727 81.407 456.41 81.407 457.332 c
h
84.031 456.596 m
84.031 456.996 83.978 457.292 83.871 457.484 c
83.727 457.746 83.468 457.876 83.095 457.876 c
82.786 457.876 82.549 457.774 82.387 457.568 c
82.224 457.363 82.143 457.034 82.143 456.58 c
82.143 456.111 82.22 455.758 82.375 455.52 c
82.53 455.283 82.786 455.165 83.143 455.165 c
83.735 455.165 84.031 455.642 84.031 456.596 c
f
75.454 433.356 m
75.454 433.943 75.473 434.38 75.51 434.668 c
75.58 435.201 75.721 435.618 75.934 435.916 c
76.201 436.284 76.582 436.468 77.078 436.468 c
77.58 436.468 77.964 436.295 78.23 435.948 c
78.444 435.671 78.585 435.266 78.654 434.732 c
78.697 434.412 78.718 433.954 78.718 433.356 c
78.718 432.791 78.7 432.37 78.662 432.093 c
78.593 431.57 78.452 431.167 78.238 430.885 c
77.966 430.522 77.58 430.341 77.078 430.341 c
76.38 430.341 75.908 430.717 75.662 431.469 c
75.524 431.895 75.454 432.524 75.454 433.356 c
h
76.126 433.356 m
76.126 433.108 l
76.126 432.17 76.206 431.57 76.366 431.309 c
76.51 431.074 76.748 430.957 77.078 430.957 c
77.478 430.957 77.75 431.21 77.894 431.717 c
77.985 432.042 78.03 432.53 78.03 433.18 c
78.03 433.356 l
78.03 434.204 77.985 434.796 77.894 435.132 c
77.761 435.628 77.489 435.876 77.078 435.876 c
76.668 435.876 76.396 435.636 76.262 435.156 c
76.172 434.831 76.126 434.231 76.126 433.356 c
f
79.719 431.269 0.736 -0.8 re
f
81.295 432.564 m
83.551 436.468 l
84.159 436.468 l
84.159 432.564 l
84.687 432.564 l
84.687 431.973 l
84.159 431.973 l
84.159 430.469 l
83.487 430.469 l
83.487 431.973 l
81.295 431.973 l
81.295 432.564 l
h
83.487 432.564 m
83.487 435.419 l
81.836 432.564 l
83.487 432.564 l
f
75.454 409.148 m
75.454 409.735 75.473 410.173 75.51 410.46 c
75.58 410.994 75.721 411.41 75.934 411.708 c
76.201 412.076 76.582 412.26 77.078 412.26 c
77.58 412.26 77.964 412.087 78.23 411.74 c
78.444 411.463 78.585 411.058 78.654 410.524 c
78.697 410.204 78.718 409.746 78.718 409.148 c
78.718 408.583 78.7 408.162 78.662 407.885 c
78.593 407.362 78.452 406.96 78.238 406.677 c
77.966 406.314 77.58 406.133 77.078 406.133 c
76.38 406.133 75.908 406.509 75.662 407.261 c
75.524 407.687 75.454 408.317 75.454 409.148 c
h
76.126 409.148 m
76.126 408.901 l
76.126 407.962 76.206 407.362 76.366 407.101 c
76.51 406.866 76.748 406.749 77.078 406.749 c
77.478 406.749 77.75 407.002 77.894 407.509 c
77.985 407.834 78.03 408.322 78.03 408.973 c
78.03 409.148 l
78.03 409.997 77.985 410.588 77.894 410.924 c
77.761 411.42 77.489 411.668 77.078 411.668 c
76.668 411.668 76.396 411.428 76.262 410.948 c
76.172 410.623 76.126 410.023 76.126 409.148 c
f
79.719 407.061 0.736 -0.8 re
f
81.439 406.261 m
81.439 406.618 81.473 406.928 81.543 407.189 c
81.633 407.536 81.785 407.81 81.999 408.013 c
82.25 408.247 82.543 408.53 82.879 408.861 c
83.135 409.111 83.349 409.327 83.523 409.508 c
83.696 409.69 83.81 409.892 83.863 410.116 c
83.895 410.245 83.911 410.439 83.911 410.7 c
83.911 411.009 83.835 411.248 83.683 411.416 c
83.531 411.584 83.319 411.668 83.047 411.668 c
82.732 411.668 82.503 411.57 82.359 411.372 c
82.193 411.148 82.111 410.783 82.111 410.276 c
82.111 410.271 82.111 410.25 82.111 410.212 c
81.487 410.212 l
81.479 410.492 l
81.479 411.079 81.616 411.52 81.891 411.816 c
82.165 412.112 82.567 412.26 83.095 412.26 c
83.601 412.26 83.986 412.095 84.247 411.764 c
84.476 411.471 84.591 411.09 84.591 410.62 c
84.591 410.226 84.519 409.885 84.374 409.597 c
84.271 409.394 84.119 409.194 83.915 408.997 c
83.743 408.831 83.571 408.669 83.399 408.509 c
83.195 408.317 82.991 408.135 82.787 407.965 c
82.519 407.73 82.344 407.554 82.264 407.437 c
82.161 407.282 82.111 407.087 82.111 406.853 c
84.655 406.853 l
84.655 406.261 l
81.439 406.261 l
f
81.455 384.941 m
81.455 385.527 81.473 385.965 81.511 386.253 c
81.58 386.786 81.721 387.202 81.935 387.5 c
82.201 387.868 82.583 388.052 83.079 388.052 c
83.58 388.052 83.964 387.879 84.231 387.532 c
84.444 387.255 84.586 386.85 84.655 386.316 c
84.698 385.996 84.719 385.538 84.719 384.941 c
84.719 384.375 84.7 383.954 84.663 383.677 c
84.594 383.154 84.452 382.752 84.239 382.469 c
83.967 382.106 83.58 381.925 83.079 381.925 c
82.38 381.925 81.908 382.301 81.663 383.053 c
81.524 383.48 81.455 384.109 81.455 384.941 c
h
82.127 384.941 m
82.127 384.693 l
82.127 383.754 82.207 383.154 82.367 382.893 c
82.511 382.658 82.748 382.541 83.079 382.541 c
83.479 382.541 83.751 382.794 83.895 383.301 c
83.986 383.626 84.031 384.114 84.031 384.765 c
84.031 384.941 l
84.031 385.789 83.986 386.38 83.895 386.716 c
83.762 387.212 83.489 387.46 83.079 387.46 c
82.668 387.46 82.396 387.22 82.263 386.74 c
82.172 386.415 82.127 385.815 82.127 384.941 c
f
1 g
109.448 452.707 m
110.384 452.707 111.148 451.943 111.148 451.006 c
111.148 450.069 110.384 449.306 109.448 449.306 c
108.511 449.306 107.746 450.069 107.746 451.006 c
107.746 451.943 108.511 452.707 109.448 452.707 c
b*
109.649 441.855 m
110.585 441.855 111.349 441.091 111.349 440.154 c
111.349 439.218 110.585 438.454 109.649 438.454 c
108.712 438.454 107.947 439.218 107.947 440.154 c
107.947 441.091 108.712 441.855 109.649 441.855 c
b*
109.448 433.415 m
110.384 433.415 111.148 432.651 111.148 431.714 c
111.148 430.778 110.384 430.014 109.448 430.014 c
108.511 430.014 107.746 430.778 107.746 431.714 c
107.746 432.651 108.511 433.415 109.448 433.415 c
b*
109.448 428.793 m
110.384 428.793 111.148 428.029 111.148 427.092 c
111.148 426.156 110.384 425.392 109.448 425.392 c
108.511 425.392 107.746 426.156 107.746 427.092 c
107.746 428.029 108.511 428.793 109.448 428.793 c
b*
107.84 422.564 m
108.776 422.564 109.54 421.8 109.54 420.863 c
109.54 419.926 108.776 419.163 107.84 419.163 c
106.903 419.163 106.138 419.926 106.138 420.863 c
106.138 421.8 106.903 422.564 107.84 422.564 c
b*
109.649 422.564 m
110.585 422.564 111.349 421.8 111.349 420.863 c
111.349 419.926 110.585 419.163 109.649 419.163 c
108.712 419.163 107.947 419.926 107.947 420.863 c
107.947 421.8 108.712 422.564 109.649 422.564 c
b*
111.257 422.765 m
112.193 422.765 112.957 422.001 112.957 421.064 c
112.957 420.127 112.193 419.363 111.257 419.363 c
110.32 419.363 109.555 420.127 109.555 421.064 c
109.555 422.001 110.32 422.765 111.257 422.765 c
b*
109.448 420.554 m
110.384 420.554 111.148 419.79 111.148 418.853 c
111.148 417.917 110.384 417.153 109.448 417.153 c
108.511 417.153 107.746 417.917 107.746 418.853 c
107.746 419.79 108.511 420.554 109.448 420.554 c
b*
109.448 418.143 m
110.384 418.143 111.148 417.379 111.148 416.442 c
111.148 415.505 110.384 414.742 109.448 414.742 c
108.511 414.742 107.746 415.505 107.746 416.442 c
107.746 417.379 108.511 418.143 109.448 418.143 c
b*
106.835 413.923 m
107.771 413.923 108.535 413.159 108.535 412.222 c
108.535 411.285 107.771 410.522 106.835 410.522 c
105.898 410.522 105.133 411.285 105.133 412.222 c
105.133 413.159 105.898 413.923 106.835 413.923 c
b*
108.242 414.124 m
109.178 414.124 109.942 413.36 109.942 412.423 c
109.942 411.486 109.178 410.723 108.242 410.723 c
107.305 410.723 106.54 411.486 106.54 412.423 c
106.54 413.36 107.305 414.124 108.242 414.124 c
b*
112.061 413.722 m
112.997 413.722 113.761 412.958 113.761 412.021 c
113.761 411.084 112.997 410.321 112.061 410.321 c
111.124 410.321 110.359 411.084 110.359 412.021 c
110.359 412.958 111.124 413.722 112.061 413.722 c
b*
105.629 415.329 m
106.565 415.329 107.329 414.565 107.329 413.629 c
107.329 412.692 106.565 411.928 105.629 411.928 c
104.692 411.928 103.927 412.692 103.927 413.629 c
103.927 414.565 104.692 415.329 105.629 415.329 c
b*
108.041 415.329 m
108.977 415.329 109.741 414.565 109.741 413.629 c
109.741 412.692 108.977 411.928 108.041 411.928 c
107.104 411.928 106.339 412.692 106.339 413.629 c
106.339 414.565 107.104 415.329 108.041 415.329 c
b*
113.467 415.329 m
114.404 415.329 115.168 414.565 115.168 413.629 c
115.168 412.692 114.404 411.928 113.467 411.928 c
112.531 411.928 111.766 412.692 111.766 413.629 c
111.766 414.565 112.531 415.329 113.467 415.329 c
b*
109.85 415.128 m
110.786 415.128 111.55 414.364 111.55 413.428 c
111.55 412.491 110.786 411.727 109.85 411.727 c
108.913 411.727 108.148 412.491 108.148 413.428 c
108.148 414.364 108.913 415.128 109.85 415.128 c
b*
112.061 415.329 m
112.997 415.329 113.761 414.565 113.761 413.629 c
113.761 412.692 112.997 411.928 112.061 411.928 c
111.124 411.928 110.359 412.692 110.359 413.629 c
110.359 414.565 111.124 415.329 112.061 415.329 c
b*
109.649 411.913 m
110.585 411.913 111.349 411.149 111.349 410.212 c
111.349 409.276 110.585 408.512 109.649 408.512 c
108.712 408.512 107.947 409.276 107.947 410.212 c
107.947 411.149 108.712 411.913 109.649 411.913 c
b*
104.825 400.861 m
105.761 400.861 106.525 400.097 106.525 399.16 c
106.525 398.223 105.761 397.46 104.825 397.46 c
103.888 397.46 103.123 398.223 103.123 399.16 c
103.123 400.097 103.888 400.861 104.825 400.861 c
b*
106.835 401.062 m
107.771 401.062 108.535 400.298 108.535 399.361 c
108.535 398.424 107.771 397.66 106.835 397.66 c
105.898 397.66 105.133 398.424 105.133 399.361 c
105.133 400.298 105.898 401.062 106.835 401.062 c
b*
109.046 401.062 m
109.982 401.062 110.746 400.298 110.746 399.361 c
110.746 398.424 109.982 397.66 109.046 397.66 c
108.109 397.66 107.344 398.424 107.344 399.361 c
107.344 400.298 108.109 401.062 109.046 401.062 c
b*
112.061 401.062 m
112.997 401.062 113.761 400.298 113.761 399.361 c
113.761 398.424 112.997 397.66 112.061 397.66 c
111.124 397.66 110.359 398.424 110.359 399.361 c
110.359 400.298 111.124 401.062 112.061 401.062 c
b*
114.07 401.062 m
115.007 401.062 115.771 400.298 115.771 399.361 c
115.771 398.424 115.007 397.66 114.07 397.66 c
113.134 397.66 112.369 398.424 112.369 399.361 c
112.369 400.298 113.134 401.062 114.07 401.062 c
b*
108.443 403.071 m
109.379 403.071 110.143 402.307 110.143 401.37 c
110.143 400.434 109.379 399.67 108.443 399.67 c
107.506 399.67 106.741 400.434 106.741 401.37 c
106.741 402.307 107.506 403.071 108.443 403.071 c
b*
110.654 403.272 m
111.59 403.272 112.354 402.508 112.354 401.571 c
112.354 400.635 111.59 399.871 110.654 399.871 c
109.717 399.871 108.952 400.635 108.952 401.571 c
108.952 402.508 109.717 403.272 110.654 403.272 c
b*
108.644 405.483 m
109.58 405.483 110.344 404.719 110.344 403.782 c
110.344 402.845 109.58 402.082 108.644 402.082 c
107.707 402.082 106.942 402.845 106.942 403.782 c
106.942 404.719 107.707 405.483 108.644 405.483 c
b*
110.654 405.684 m
111.59 405.684 112.354 404.919 112.354 403.983 c
112.354 403.046 111.59 402.283 110.654 402.283 c
109.717 402.283 108.952 403.046 108.952 403.983 c
108.952 404.919 109.717 405.684 110.654 405.684 c
b*
105.629 407.09 m
106.565 407.09 107.329 406.326 107.329 405.389 c
107.329 404.453 106.565 403.689 105.629 403.689 c
104.692 403.689 103.927 404.453 103.927 405.389 c
103.927 406.326 104.692 407.09 105.629 407.09 c
b*
108.041 406.889 m
108.977 406.889 109.741 406.125 109.741 405.189 c
109.741 404.252 108.977 403.488 108.041 403.488 c
107.104 403.488 106.339 404.252 106.339 405.189 c
106.339 406.125 107.104 406.889 108.041 406.889 c
b*
110.252 406.487 m
111.188 406.487 111.952 405.723 111.952 404.787 c
111.952 403.85 111.188 403.086 110.252 403.086 c
109.315 403.086 108.55 403.85 108.55 404.787 c
108.55 405.723 109.315 406.487 110.252 406.487 c
b*
113.267 407.09 m
114.203 407.09 114.967 406.326 114.967 405.389 c
114.967 404.453 114.203 403.689 113.267 403.689 c
112.33 403.689 111.565 404.453 111.565 405.389 c
111.565 406.326 112.33 407.09 113.267 407.09 c
b*
108.242 409.301 m
109.178 409.301 109.942 408.537 109.942 407.6 c
109.942 406.663 109.178 405.9 108.242 405.9 c
107.305 405.9 106.54 406.663 106.54 407.6 c
106.54 408.537 107.305 409.301 108.242 409.301 c
b*
109.85 408.899 m
110.786 408.899 111.55 408.135 111.55 407.198 c
111.55 406.262 110.786 405.498 109.85 405.498 c
108.913 405.498 108.148 406.262 108.148 407.198 c
108.148 408.135 108.913 408.899 109.85 408.899 c
b*
111.659 409.301 m
112.595 409.301 113.359 408.537 113.359 407.6 c
113.359 406.663 112.595 405.9 111.659 405.9 c
110.722 405.9 109.957 406.663 109.957 407.6 c
109.957 408.537 110.722 409.301 111.659 409.301 c
b*
109.649 397.445 m
110.585 397.445 111.349 396.68 111.349 395.744 c
111.349 394.807 110.585 394.043 109.649 394.043 c
108.712 394.043 107.947 394.807 107.947 395.744 c
107.947 396.68 108.712 397.445 109.649 397.445 c
b*
109.649 394.028 m
110.585 394.028 111.349 393.264 111.349 392.327 c
111.349 391.391 110.585 390.627 109.649 390.627 c
108.712 390.627 107.947 391.391 107.947 392.327 c
107.947 393.264 108.712 394.028 109.649 394.028 c
b*
0.8 g
208.437 465.734 m
210.28 462.05 l
206.595 462.05 l
208.437 465.734 l
b*
207.633 455.285 m
209.476 451.6 l
205.791 451.6 l
207.633 455.285 l
b*
209.643 455.285 m
211.486 451.6 l
207.801 451.6 l
209.643 455.285 l
b*
208.638 453.275 m
210.481 449.591 l
206.796 449.591 l
208.638 453.275 l
b*
209.193 444.886 m
211.035 441.202 l
207.35 441.202 l
209.193 444.886 l
b*
207.954 440.097 m
209.939 436.129 l
205.97 436.129 l
207.954 440.097 l
b*
209.082 443.203 m
210.925 439.519 l
207.239 439.519 l
209.082 443.203 l
b*
210.461 440.044 m
212.304 436.359 l
208.618 436.359 l
210.461 440.044 l
b*
209.236 427.695 m
211.078 424.011 l
207.393 424.011 l
209.236 427.695 l
b*
208.222 430.19 m
210.065 426.505 l
206.38 426.505 l
208.222 430.19 l
b*
210.405 430.034 m
212.248 426.349 l
208.562 426.349 l
210.405 430.034 l
b*
208.456 432.918 m
210.299 429.233 l
206.613 429.233 l
208.456 432.918 l
b*
210.303 432.727 m
212.146 429.043 l
208.461 429.043 l
210.303 432.727 l
b*
209.076 434.632 m
210.919 430.948 l
207.234 430.948 l
209.076 434.632 l
b*
206.712 419.689 m
208.555 416.004 l
204.87 416.004 l
206.712 419.689 l
b*
208.543 419.765 m
210.385 416.08 l
206.7 416.08 l
208.543 419.765 l
b*
210.602 419.689 m
212.444 416.004 l
208.759 416.004 l
210.602 419.689 l
b*
211.822 419.689 m
213.664 416.004 l
209.979 416.004 l
211.822 419.689 l
b*
208.009 422.281 m
209.851 418.596 l
206.166 418.596 l
208.009 422.281 l
b*
210.525 421.976 m
212.368 418.291 l
208.683 418.291 l
210.525 421.976 l
b*
209.076 423.958 m
210.919 420.274 l
207.234 420.274 l
209.076 423.958 l
b*
205.797 413.437 m
207.64 409.752 l
203.955 409.752 l
205.797 413.437 l
b*
207.399 413.437 m
209.241 409.752 l
205.556 409.752 l
207.399 413.437 l
b*
209.076 413.665 m
210.919 409.981 l
207.234 409.981 l
209.076 413.665 l
b*
211.212 413.742 m
213.054 410.057 l
209.369 410.057 l
211.212 413.742 l
b*
212.737 413.513 m
214.58 409.828 l
210.894 409.828 l
212.737 413.513 l
b*
208.085 415.953 m
209.928 412.268 l
206.242 412.268 l
208.085 415.953 l
b*
210.525 416.181 m
212.368 412.497 l
208.683 412.497 l
210.525 416.181 l
b*
208.466 403.83 m
210.309 400.145 l
206.624 400.145 l
208.466 403.83 l
b*
210.449 403.83 m
212.292 400.145 l
208.606 400.145 l
210.449 403.83 l
b*
209.305 405.126 m
211.148 401.441 l
207.462 401.441 l
209.305 405.126 l
b*
208.314 407.642 m
210.157 403.958 l
206.471 403.958 l
208.314 407.642 l
b*
210.068 407.566 m
211.91 403.881 l
208.225 403.881 l
210.068 407.566 l
b*
209.153 410.463 m
210.995 406.779 l
207.31 406.779 l
209.153 410.463 l
b*
0.216 w
91.266 529.052 188.207 -144.166 re
88.491 505.781 m
91.325 505.781 l
88.491 481.729 m
91.325 481.729 l
88.491 457.141 m
91.325 457.141 l
88.491 433.142 m
91.325 433.142 l
88.491 409.036 m
91.325 409.036 l
88.491 384.899 m
91.325 384.899 l
S
0 g
75.913 368.02 m
77.404 373.284 l
78.181 373.284 l
79.658 368.02 l
79.012 368.02 l
78.601 369.539 l
76.935 369.539 l
76.556 368.02 l
75.913 368.02 l
h
78.465 370.057 m
77.782 372.858 l
77.076 370.057 l
78.465 370.057 l
f
80.232 368.02 m
80.232 371.919 l
80.792 371.919 l
80.792 371.478 l
80.797 371.51 80.853 371.576 80.96 371.674 c
81.217 371.907 81.466 372.024 81.709 372.024 c
82.05 372.024 82.307 371.937 82.479 371.765 c
82.652 371.592 82.738 371.319 82.738 370.946 c
82.738 368.02 l
82.178 368.02 l
82.178 370.673 l
82.178 370.981 82.152 371.191 82.101 371.303 c
82.022 371.476 81.861 371.562 81.618 371.562 c
81.385 371.562 81.189 371.487 81.03 371.338 c
80.871 371.188 80.792 370.976 80.792 370.701 c
80.792 368.02 l
80.232 368.02 l
f
83.83 368.797 m
83.83 371.45 l
83.298 371.45 l
83.298 371.919 l
83.83 371.919 l
83.83 372.969 l
84.376 372.969 l
84.376 371.919 l
85.034 371.919 l
85.034 371.45 l
84.376 371.45 l
84.376 368.734 l
84.376 368.646 84.394 368.582 84.429 368.542 c
84.464 368.502 84.537 368.482 84.649 368.482 c
85.006 368.482 l
85.006 368.02 l
84.404 368.02 l
84.152 368.02 83.989 368.083 83.914 368.209 c
83.858 368.303 83.83 368.498 83.83 368.797 c
f
85.685 371.919 0.532 -3.899 re
85.685 373.102 0.532 -0.7 re
f
87.232 366.705 m
87.232 371.919 l
87.765 371.919 l
87.765 371.464 l
87.984 371.837 88.28 372.024 88.654 372.024 c
89.041 372.024 89.342 371.84 89.557 371.471 c
89.757 371.13 89.858 370.687 89.858 370.141 c
89.858 369.394 89.758 368.844 89.561 368.489 c
89.35 368.111 89.033 367.922 88.611 367.922 c
88.39 367.922 88.209 367.978 88.068 368.09 c
88.025 368.123 87.924 368.237 87.765 368.433 c
87.765 366.705 l
87.232 366.705 l
h
87.765 369.945 m
87.765 369.339 87.838 368.918 87.984 368.685 c
88.111 368.48 88.301 368.377 88.556 368.377 c
88.829 368.377 89.027 368.557 89.149 368.916 c
89.239 369.182 89.284 369.521 89.284 369.931 c
89.284 370.402 89.244 370.762 89.163 371.009 c
89.046 371.378 88.833 371.562 88.527 371.562 c
88.212 371.562 87.996 371.38 87.878 371.016 c
87.802 370.778 87.765 370.421 87.765 369.945 c
f
90.747 368.034 m
90.747 373.284 l
91.307 373.284 l
91.307 371.506 l
91.391 371.65 91.531 371.773 91.727 371.873 c
91.923 371.974 92.126 372.024 92.336 372.024 c
92.602 372.024 92.812 371.947 92.966 371.793 c
93.148 371.615 93.239 371.342 93.239 370.974 c
93.239 368.034 l
92.679 368.034 l
92.679 370.729 l
92.679 371.004 92.644 371.205 92.574 371.331 c
92.49 371.485 92.34 371.562 92.126 371.562 c
91.892 371.562 91.698 371.486 91.541 371.334 c
91.385 371.183 91.307 370.962 91.307 370.673 c
91.307 368.034 l
90.747 368.034 l
f
94.086 370.029 m
94.086 370.622 94.184 371.086 94.38 371.422 c
94.609 371.814 94.966 372.01 95.451 372.01 c
95.96 372.01 96.328 371.84 96.557 371.499 c
96.767 371.181 96.872 370.687 96.872 370.015 c
96.872 369.357 96.776 368.856 96.585 368.51 c
96.366 368.109 96.011 367.908 95.521 367.908 c
95.012 367.908 94.637 368.116 94.394 368.531 c
94.189 368.886 94.086 369.385 94.086 370.029 c
h
94.66 370.015 m
94.66 369.525 94.697 369.17 94.772 368.951 c
94.898 368.578 95.143 368.391 95.507 368.391 c
95.848 368.391 96.076 368.583 96.193 368.965 c
96.263 369.189 96.298 369.521 96.298 369.959 c
96.298 370.426 96.258 370.776 96.179 371.009 c
96.053 371.378 95.82 371.562 95.479 371.562 c
95.134 371.562 94.898 371.366 94.772 370.974 c
94.697 370.745 94.66 370.426 94.66 370.015 c
f
97.53 370.974 m
97.53 371.291 97.63 371.546 97.83 371.737 c
98.029 371.928 98.319 372.024 98.699 372.024 c
99.075 372.024 99.361 371.942 99.558 371.779 c
99.783 371.592 99.896 371.291 99.896 370.876 c
99.35 370.876 l
99.35 371.118 99.306 371.291 99.216 371.394 c
99.126 371.497 98.967 371.548 98.741 371.548 c
98.529 371.548 98.37 371.502 98.264 371.411 c
98.158 371.32 98.104 371.198 98.104 371.044 c
98.104 370.764 98.206 370.565 98.408 370.449 c
98.487 370.402 98.699 370.312 99.042 370.179 c
99.385 370.047 99.636 369.902 99.793 369.746 c
99.951 369.589 100.029 369.392 100.029 369.154 c
100.029 368.753 99.911 368.447 99.676 368.237 c
99.44 368.027 99.122 367.922 98.72 367.922 c
98.249 367.922 97.917 368.062 97.726 368.342 c
97.595 368.534 97.53 368.804 97.53 369.154 c
98.062 369.154 l
98.062 368.907 98.102 368.725 98.181 368.608 c
98.279 368.464 98.459 368.391 98.72 368.391 c
98.954 368.391 99.134 368.444 99.263 368.549 c
99.391 368.654 99.455 368.797 99.455 368.979 c
99.455 369.212 99.39 369.38 99.258 369.483 c
99.177 369.549 98.958 369.644 98.599 369.77 c
98.238 369.896 98 370.008 97.882 370.106 c
97.648 370.297 97.53 370.586 97.53 370.974 c
f
100.834 366.705 m
100.834 371.919 l
101.366 371.919 l
101.366 371.464 l
101.585 371.837 101.882 372.024 102.255 372.024 c
102.643 372.024 102.944 371.84 103.158 371.471 c
103.359 371.13 103.459 370.687 103.459 370.141 c
103.459 369.394 103.36 368.844 103.163 368.489 c
102.952 368.111 102.634 367.922 102.212 367.922 c
101.992 367.922 101.811 367.978 101.67 368.09 c
101.626 368.123 101.526 368.237 101.366 368.433 c
101.366 366.705 l
100.834 366.705 l
h
101.366 369.945 m
101.366 369.339 101.44 368.918 101.585 368.685 c
101.713 368.48 101.903 368.377 102.157 368.377 c
102.43 368.377 102.629 368.557 102.751 368.916 c
102.841 369.182 102.885 369.521 102.885 369.931 c
102.885 370.402 102.845 370.762 102.765 371.009 c
102.647 371.378 102.435 371.562 102.129 371.562 c
101.814 371.562 101.597 371.38 101.479 371.016 c
101.403 370.778 101.366 370.421 101.366 369.945 c
f
104.348 368.034 m
104.348 373.284 l
104.908 373.284 l
104.908 371.506 l
104.992 371.65 105.132 371.773 105.329 371.873 c
105.524 371.974 105.727 372.024 105.937 372.024 c
106.203 372.024 106.413 371.947 106.567 371.793 c
106.749 371.615 106.84 371.342 106.84 370.974 c
106.84 368.034 l
106.28 368.034 l
106.28 370.729 l
106.28 371.004 106.245 371.205 106.175 371.331 c
106.091 371.485 105.942 371.562 105.727 371.562 c
105.494 371.562 105.299 371.486 105.143 371.334 c
104.987 371.183 104.908 370.962 104.908 370.673 c
104.908 368.034 l
104.348 368.034 l
f
107.687 370.029 m
107.687 370.622 107.786 371.086 107.982 371.422 c
108.21 371.814 108.567 372.01 109.053 372.01 c
109.561 372.01 109.93 371.84 110.159 371.499 c
110.369 371.181 110.474 370.687 110.474 370.015 c
110.474 369.357 110.378 368.856 110.187 368.51 c
109.967 368.109 109.613 367.908 109.123 367.908 c
108.614 367.908 108.238 368.116 107.996 368.531 c
107.79 368.886 107.687 369.385 107.687 370.029 c
h
108.261 370.015 m
108.261 369.525 108.299 369.17 108.373 368.951 c
108.5 368.578 108.745 368.391 109.109 368.391 c
109.449 368.391 109.678 368.583 109.795 368.965 c
109.865 369.189 109.9 369.521 109.9 369.959 c
109.9 370.426 109.86 370.776 109.781 371.009 c
109.655 371.378 109.421 371.562 109.081 371.562 c
108.735 371.562 108.5 371.366 108.373 370.974 c
108.299 370.745 108.261 370.426 108.261 370.015 c
f
111.335 373.284 0.546 -5.263 re
f
112.91 371.919 0.532 -3.899 re
112.91 373.102 0.532 -0.7 re
f
114.457 366.705 m
114.457 371.919 l
114.989 371.919 l
114.989 371.464 l
115.208 371.837 115.505 372.024 115.878 372.024 c
116.265 372.024 116.566 371.84 116.781 371.471 c
116.982 371.13 117.082 370.687 117.082 370.141 c
117.082 369.394 116.983 368.844 116.786 368.489 c
116.575 368.111 116.257 367.922 115.835 367.922 c
115.615 367.922 115.434 367.978 115.292 368.09 c
115.249 368.123 115.149 368.237 114.989 368.433 c
114.989 366.705 l
114.457 366.705 l
h
114.989 369.945 m
114.989 369.339 115.063 368.918 115.208 368.685 c
115.336 368.48 115.526 368.377 115.78 368.377 c
116.053 368.377 116.252 368.557 116.374 368.916 c
116.464 369.182 116.508 369.521 116.508 369.931 c
116.508 370.402 116.468 370.762 116.388 371.009 c
116.27 371.378 116.058 371.562 115.752 371.562 c
115.437 371.562 115.22 371.38 115.102 371.016 c
115.026 370.778 114.989 370.421 114.989 369.945 c
f
117.971 371.919 0.532 -3.899 re
117.971 373.102 0.532 -0.7 re
f
119.35 369.896 m
119.35 370.489 119.406 370.939 119.518 371.247 c
119.705 371.765 120.055 372.024 120.568 372.024 c
120.732 372.024 120.887 371.977 121.034 371.884 c
121.181 371.79 121.313 371.66 121.429 371.492 c
121.429 373.284 l
121.976 373.284 l
121.976 368.02 l
121.457 368.02 l
121.457 368.538 l
121.346 368.337 121.232 368.191 121.116 368.097 c
120.957 367.971 120.762 367.908 120.53 367.908 c
120.088 367.908 119.767 368.118 119.566 368.538 c
119.423 368.846 119.35 369.238 119.35 369.714 c
119.35 369.896 l
h
121.429 369.973 m
121.429 370.477 121.381 370.85 121.284 371.093 c
121.159 371.406 120.944 371.562 120.638 371.562 c
120.339 371.562 120.13 371.342 120.014 370.904 c
119.945 370.638 119.91 370.293 119.91 369.868 c
119.91 369.43 119.943 369.108 120.007 368.902 c
120.113 368.562 120.315 368.391 120.61 368.391 c
120.888 368.391 121.09 368.498 121.215 368.713 c
121.358 368.96 121.429 369.38 121.429 369.973 c
f
124.482 368.965 m
124.482 369.282 124.54 369.527 124.657 369.7 c
124.755 369.849 124.911 369.964 125.126 370.043 c
125.959 370.386 l
126.038 370.414 126.118 370.444 126.197 370.477 c
126.276 370.524 126.316 370.594 126.316 370.687 c
126.316 371.093 l
126.316 371.224 126.276 371.328 126.197 371.408 c
126.094 371.51 125.943 371.562 125.742 371.562 c
125.499 371.562 125.338 371.513 125.259 371.415 c
125.18 371.317 125.14 371.137 125.14 370.876 c
124.636 370.876 l
124.636 371.282 124.733 371.574 124.926 371.754 c
125.12 371.934 125.392 372.024 125.742 372.024 c
126.218 372.024 126.538 371.891 126.701 371.625 c
126.799 371.466 126.848 371.217 126.848 370.876 c
126.848 368.783 l
126.848 368.625 126.86 368.524 126.883 368.482 c
126.906 368.44 126.955 368.415 127.03 368.405 c
127.053 368.415 127.081 368.419 127.114 368.419 c
127.147 368.419 127.172 368.419 127.191 368.419 c
127.191 368.02 l
126.848 367.992 l
126.666 367.992 126.54 368.037 126.466 368.125 c
126.394 368.214 126.358 368.361 126.358 368.566 c
126.251 368.333 126.108 368.163 125.931 368.055 c
125.786 367.967 125.618 367.922 125.427 367.922 c
125.058 367.922 124.799 368.034 124.65 368.258 c
124.538 368.426 124.482 368.662 124.482 368.965 c
h
126.274 370.127 m
125.896 369.95 125.644 369.831 125.518 369.77 c
125.21 369.621 125.056 369.366 125.056 369.007 c
125.056 368.797 125.104 368.64 125.2 368.535 c
125.295 368.43 125.417 368.377 125.567 368.377 c
125.744 368.377 125.907 368.446 126.053 368.584 c
126.2 368.722 126.274 368.898 126.274 369.112 c
126.274 370.127 l
f
127.87 368.02 m
127.87 371.919 l
128.43 371.919 l
128.43 371.478 l
128.435 371.51 128.491 371.576 128.598 371.674 c
128.855 371.907 129.104 372.024 129.347 372.024 c
129.688 372.024 129.944 371.937 130.117 371.765 c
130.29 371.592 130.376 371.319 130.376 370.946 c
130.376 368.02 l
129.816 368.02 l
129.816 370.673 l
129.816 370.981 129.79 371.191 129.739 371.303 c
129.66 371.476 129.499 371.562 129.256 371.562 c
129.023 371.562 128.827 371.487 128.668 371.338 c
128.509 371.188 128.43 370.976 128.43 370.701 c
128.43 368.02 l
127.87 368.02 l
f
131.468 368.797 m
131.468 371.45 l
130.936 371.45 l
130.936 371.919 l
131.468 371.919 l
131.468 372.969 l
132.014 372.969 l
132.014 371.919 l
132.672 371.919 l
132.672 371.45 l
132.014 371.45 l
132.014 368.734 l
132.014 368.646 132.032 368.582 132.067 368.542 c
132.102 368.502 132.175 368.482 132.287 368.482 c
132.644 368.482 l
132.644 368.02 l
132.042 368.02 l
131.79 368.02 131.627 368.083 131.552 368.209 c
131.496 368.303 131.468 368.498 131.468 368.797 c
f
133.323 371.919 0.532 -3.899 re
133.323 373.102 0.532 -0.7 re
f
134.898 368.02 m
134.898 373.284 l
135.444 373.284 l
135.444 371.52 l
135.561 371.692 135.684 371.82 135.812 371.901 c
135.94 371.983 136.088 372.024 136.256 372.024 c
136.672 372.024 136.982 371.864 137.188 371.544 c
137.393 371.225 137.495 370.757 137.495 370.141 c
137.495 369.376 137.398 368.815 137.201 368.458 c
137.006 368.101 136.697 367.922 136.277 367.922 c
135.913 367.922 135.622 368.109 135.402 368.482 c
135.402 368.02 l
134.898 368.02 l
h
135.402 369.854 m
135.402 369.322 135.464 368.943 135.588 368.717 c
135.711 368.491 135.916 368.377 136.2 368.377 c
136.49 368.377 136.693 368.559 136.809 368.923 c
136.884 369.161 136.921 369.476 136.921 369.868 c
136.921 370.127 l
136.921 370.57 136.863 370.92 136.746 371.177 c
136.63 371.433 136.452 371.562 136.214 371.562 c
135.86 371.562 135.624 371.368 135.507 370.981 c
135.437 370.747 135.402 370.372 135.402 369.854 c
f
138.223 370.029 m
138.223 370.622 138.322 371.086 138.518 371.422 c
138.746 371.814 139.103 372.01 139.589 372.01 c
140.097 372.01 140.466 371.84 140.695 371.499 c
140.905 371.181 141.01 370.687 141.01 370.015 c
141.01 369.357 140.914 368.856 140.723 368.51 c
140.503 368.109 140.149 367.908 139.659 367.908 c
139.15 367.908 138.774 368.116 138.532 368.531 c
138.326 368.886 138.223 369.385 138.223 370.029 c
h
138.797 370.015 m
138.797 369.525 138.835 369.17 138.909 368.951 c
139.036 368.578 139.281 368.391 139.645 368.391 c
139.985 368.391 140.214 368.583 140.331 368.965 c
140.401 369.189 140.436 369.521 140.436 369.959 c
140.436 370.426 140.396 370.776 140.317 371.009 c
140.191 371.378 139.957 371.562 139.617 371.562 c
139.271 371.562 139.036 371.366 138.909 370.974 c
138.835 370.745 138.797 370.426 138.797 370.015 c
f
141.703 369.896 m
141.703 370.489 141.759 370.939 141.871 371.247 c
142.057 371.765 142.407 372.024 142.921 372.024 c
143.084 372.024 143.239 371.977 143.386 371.884 c
143.533 371.79 143.665 371.66 143.782 371.492 c
143.782 373.284 l
144.328 373.284 l
144.328 368.02 l
143.81 368.02 l
143.81 368.538 l
143.698 368.337 143.585 368.191 143.468 368.097 c
143.309 367.971 143.114 367.908 142.882 367.908 c
142.44 367.908 142.119 368.118 141.919 368.538 c
141.775 368.846 141.703 369.238 141.703 369.714 c
141.703 369.896 l
h
143.782 369.973 m
143.782 370.477 143.733 370.85 143.636 371.093 c
143.511 371.406 143.296 371.562 142.991 371.562 c
142.691 371.562 142.482 371.342 142.367 370.904 c
142.298 370.638 142.263 370.293 142.263 369.868 c
142.263 369.43 142.295 369.108 142.359 368.902 c
142.466 368.562 142.668 368.391 142.963 368.391 c
143.241 368.391 143.442 368.498 143.567 368.713 c
143.711 368.96 143.782 369.38 143.782 369.973 c
f
145.042 367.257 m
145.196 367.202 145.338 367.173 145.469 367.173 c
145.632 367.173 145.771 367.233 145.885 367.352 c
146 367.471 146.09 367.67 146.155 367.95 c
144.909 371.919 l
145.483 371.919 l
146.372 368.524 l
147.275 371.919 l
147.849 371.919 l
146.792 368.524 l
146.587 367.89 146.475 367.547 146.456 367.495 c
146.339 367.197 146.216 366.994 146.085 366.887 c
146.01 366.83 145.917 366.785 145.805 366.75 c
145.693 366.715 145.562 366.698 145.413 366.698 c
145.334 366.698 145.267 366.701 145.213 366.708 c
145.16 366.715 145.102 366.728 145.042 366.747 c
145.042 367.257 l
f
150.019 370.974 m
150.019 371.291 150.12 371.546 150.319 371.737 c
150.519 371.928 150.808 372.024 151.188 372.024 c
151.564 372.024 151.85 371.942 152.047 371.779 c
152.272 371.592 152.385 371.291 152.385 370.876 c
151.839 370.876 l
151.839 371.118 151.795 371.291 151.705 371.394 c
151.615 371.497 151.457 371.548 151.23 371.548 c
151.018 371.548 150.859 371.502 150.753 371.411 c
150.647 371.32 150.593 371.198 150.593 371.044 c
150.593 370.764 150.695 370.565 150.897 370.449 c
150.976 370.402 151.188 370.312 151.531 370.179 c
151.874 370.047 152.125 369.902 152.283 369.746 c
152.44 369.589 152.518 369.392 152.518 369.154 c
152.518 368.753 152.401 368.447 152.165 368.237 c
151.929 368.027 151.611 367.922 151.209 367.922 c
150.738 367.922 150.407 368.062 150.215 368.342 c
150.084 368.534 150.019 368.804 150.019 369.154 c
150.551 369.154 l
150.551 368.907 150.591 368.725 150.67 368.608 c
150.768 368.464 150.948 368.391 151.209 368.391 c
151.443 368.391 151.624 368.444 151.752 368.549 c
151.88 368.654 151.944 368.797 151.944 368.979 c
151.944 369.212 151.879 369.38 151.747 369.483 c
151.667 369.549 151.447 369.644 151.088 369.77 c
150.727 369.896 150.489 370.008 150.372 370.106 c
150.137 370.297 150.019 370.586 150.019 370.974 c
f
152.994 367.257 m
153.148 367.202 153.291 367.173 153.421 367.173 c
153.585 367.173 153.724 367.233 153.838 367.352 c
153.952 367.471 154.042 367.67 154.107 367.95 c
152.861 371.919 l
153.435 371.919 l
154.324 368.524 l
155.227 371.919 l
155.802 371.919 l
154.744 368.524 l
154.539 367.89 154.427 367.547 154.408 367.495 c
154.292 367.197 154.168 366.994 154.037 366.887 c
153.963 366.83 153.869 366.785 153.757 366.75 c
153.645 366.715 153.515 366.698 153.365 366.698 c
153.286 366.698 153.22 366.701 153.166 366.708 c
153.112 366.715 153.055 366.728 152.994 366.747 c
152.994 367.257 l
f
156.424 368.02 m
156.424 371.919 l
156.984 371.919 l
156.984 371.478 l
156.989 371.51 157.045 371.576 157.152 371.674 c
157.409 371.907 157.659 372.024 157.901 372.024 c
158.242 372.024 158.499 371.937 158.672 371.765 c
158.844 371.592 158.93 371.319 158.93 370.946 c
158.93 368.02 l
158.37 368.02 l
158.37 370.673 l
158.37 370.981 158.345 371.191 158.293 371.303 c
158.214 371.476 158.053 371.562 157.81 371.562 c
157.577 371.562 157.381 371.487 157.222 371.338 c
157.064 371.188 156.984 370.976 156.984 370.701 c
156.984 368.02 l
156.424 368.02 l
f
159.756 369.896 m
159.756 370.489 159.813 370.939 159.925 371.247 c
160.111 371.765 160.461 372.024 160.975 372.024 c
161.138 372.024 161.293 371.977 161.44 371.884 c
161.587 371.79 161.719 371.66 161.836 371.492 c
161.836 373.284 l
162.382 373.284 l
162.382 368.02 l
161.864 368.02 l
161.864 368.538 l
161.752 368.337 161.639 368.191 161.522 368.097 c
161.363 367.971 161.168 367.908 160.936 367.908 c
160.494 367.908 160.173 368.118 159.972 368.538 c
159.829 368.846 159.756 369.238 159.756 369.714 c
159.756 369.896 l
h
161.836 369.973 m
161.836 370.477 161.787 370.85 161.69 371.093 c
161.565 371.406 161.35 371.562 161.045 371.562 c
160.745 371.562 160.536 371.342 160.42 370.904 c
160.352 370.638 160.317 370.293 160.317 369.868 c
160.317 369.43 160.349 369.108 160.413 368.902 c
160.52 368.562 160.721 368.391 161.017 368.391 c
161.294 368.391 161.496 368.498 161.621 368.713 c
161.764 368.96 161.836 369.38 161.836 369.973 c
f
163.495 368.02 m
163.495 371.933 l
164.013 371.933 l
164.013 371.261 l
164.139 371.508 164.272 371.681 164.412 371.779 c
164.589 371.905 164.844 371.968 165.175 371.968 c
165.175 371.394 l
165.091 371.408 165.037 371.416 165.014 371.418 c
164.99 371.421 164.949 371.422 164.888 371.422 c
164.626 371.422 164.42 371.325 164.268 371.131 c
164.117 370.938 164.041 370.661 164.041 370.302 c
164.041 368.02 l
163.495 368.02 l
f
165.602 370.029 m
165.602 370.622 165.7 371.086 165.896 371.422 c
166.124 371.814 166.482 372.01 166.967 372.01 c
167.476 372.01 167.844 371.84 168.073 371.499 c
168.283 371.181 168.388 370.687 168.388 370.015 c
168.388 369.357 168.292 368.856 168.101 368.51 c
167.881 368.109 167.527 367.908 167.037 367.908 c
166.528 367.908 166.152 368.116 165.91 368.531 c
165.705 368.886 165.602 369.385 165.602 370.029 c
h
166.176 370.015 m
166.176 369.525 166.213 369.17 166.288 368.951 c
166.414 368.578 166.659 368.391 167.023 368.391 c
167.364 368.391 167.592 368.583 167.709 368.965 c
167.779 369.189 167.814 369.521 167.814 369.959 c
167.814 370.426 167.774 370.776 167.695 371.009 c
167.569 371.378 167.335 371.562 166.995 371.562 c
166.649 371.562 166.414 371.366 166.288 370.974 c
166.213 370.745 166.176 370.426 166.176 370.015 c
f
169.277 368.02 m
169.277 371.919 l
169.809 371.919 l
169.809 371.408 l
169.921 371.599 170.065 371.75 170.24 371.859 c
170.415 371.969 170.591 372.024 170.768 372.024 c
170.964 372.024 171.137 371.974 171.286 371.873 c
171.436 371.773 171.564 371.613 171.671 371.394 c
171.802 371.59 171.951 371.744 172.119 371.856 c
172.287 371.968 172.478 372.024 172.693 372.024 c
173.085 372.024 173.361 371.886 173.519 371.611 c
173.617 371.443 173.666 371.23 173.666 370.974 c
173.666 368.02 l
173.12 368.02 l
173.12 370.904 l
173.12 371.077 173.094 371.209 173.043 371.303 c
172.954 371.466 172.789 371.548 172.546 371.548 c
172.308 371.548 172.122 371.482 171.986 371.352 c
171.832 371.203 171.755 370.976 171.755 370.673 c
171.755 368.02 l
171.195 368.02 l
171.195 370.757 l
171.195 371.027 171.16 371.221 171.089 371.338 c
171.004 371.478 170.853 371.548 170.636 371.548 c
170.419 371.548 170.241 371.492 170.099 371.38 c
169.906 371.226 169.809 370.99 169.809 370.673 c
169.809 368.02 l
169.277 368.02 l
f
174.485 369.917 m
174.485 370.43 174.548 370.855 174.673 371.191 c
174.882 371.746 175.237 372.024 175.738 372.024 c
176.225 372.024 176.562 371.835 176.747 371.457 c
176.872 371.2 176.935 370.815 176.935 370.302 c
176.935 369.917 l
175.059 369.917 l
175.045 369.728 l
175.045 369.345 175.08 369.054 175.15 368.853 c
175.257 368.545 175.451 368.391 175.731 368.391 c
176.021 368.391 176.217 368.506 176.319 368.734 c
176.38 368.869 176.41 369.066 176.41 369.322 c
176.935 369.322 l
176.935 368.888 176.84 368.552 176.648 368.314 c
176.434 368.044 176.128 367.908 175.731 367.908 c
175.223 367.908 174.868 368.167 174.667 368.685 c
174.546 369.002 174.485 369.413 174.485 369.917 c
h
176.361 370.372 m
176.361 370.834 176.306 371.148 176.197 371.313 c
176.087 371.479 175.937 371.562 175.745 371.562 c
175.535 371.562 175.372 371.48 175.255 371.317 c
175.115 371.116 175.045 370.801 175.045 370.372 c
176.361 370.372 l
f
76.032 360.331 m
78.514 364.542 l
76.092 364.542 l
76.092 365.06 l
79.117 365.06 l
79.117 364.542 l
76.624 360.328 l
79.145 360.328 l
79.145 359.811 l
76.036 359.811 l
76.032 360.331 l
f
79.63 361.707 m
79.63 362.221 79.693 362.645 79.818 362.981 c
80.027 363.536 80.381 363.814 80.883 363.814 c
81.369 363.814 81.707 363.625 81.892 363.247 c
82.017 362.99 82.08 362.605 82.08 362.092 c
82.08 361.707 l
80.204 361.707 l
80.19 361.518 l
80.19 361.136 80.225 360.844 80.295 360.644 c
80.402 360.335 80.596 360.182 80.876 360.182 c
81.165 360.182 81.361 360.296 81.464 360.525 c
81.525 360.66 81.555 360.856 81.555 361.112 c
82.08 361.112 l
82.08 360.678 81.984 360.343 81.793 360.104 c
81.578 359.834 81.273 359.699 80.876 359.699 c
80.367 359.699 80.013 359.958 79.812 360.475 c
79.691 360.793 79.63 361.203 79.63 361.707 c
h
81.506 362.162 m
81.506 362.624 81.451 362.938 81.342 363.104 c
81.232 363.269 81.081 363.352 80.89 363.352 c
80.68 363.352 80.517 363.27 80.4 363.107 c
80.26 362.906 80.19 362.592 80.19 362.162 c
81.506 362.162 l
f
82.731 362.764 m
82.731 363.081 82.831 363.336 83.031 363.527 c
83.23 363.718 83.52 363.814 83.9 363.814 c
84.276 363.814 84.561 363.732 84.759 363.569 c
84.984 363.382 85.097 363.081 85.097 362.666 c
84.551 362.666 l
84.551 362.909 84.507 363.081 84.417 363.184 c
84.327 363.287 84.168 363.338 83.942 363.338 c
83.73 363.338 83.571 363.292 83.465 363.201 c
83.359 363.111 83.305 362.988 83.305 362.834 c
83.305 362.554 83.407 362.356 83.608 362.239 c
83.688 362.192 83.9 362.103 84.243 361.97 c
84.586 361.837 84.837 361.692 84.994 361.536 c
85.152 361.38 85.23 361.182 85.23 360.944 c
85.23 360.543 85.112 360.237 84.877 360.028 c
84.641 359.818 84.322 359.712 83.921 359.712 c
83.45 359.712 83.118 359.852 82.927 360.133 c
82.796 360.324 82.731 360.595 82.731 360.944 c
83.263 360.944 l
83.263 360.697 83.303 360.515 83.382 360.398 c
83.48 360.254 83.66 360.182 83.921 360.182 c
84.154 360.182 84.335 360.234 84.464 360.339 c
84.592 360.444 84.656 360.587 84.656 360.769 c
84.656 361.003 84.591 361.171 84.459 361.273 c
84.378 361.339 84.159 361.434 83.8 361.56 c
83.439 361.686 83.201 361.798 83.083 361.896 c
82.849 362.088 82.731 362.377 82.731 362.764 c
f
86.035 358.495 m
86.035 363.709 l
86.567 363.709 l
86.567 363.254 l
86.786 363.627 87.083 363.814 87.456 363.814 c
87.843 363.814 88.144 363.63 88.359 363.261 c
88.56 362.92 88.66 362.477 88.66 361.931 c
88.66 361.185 88.561 360.634 88.364 360.279 c
88.153 359.902 87.835 359.712 87.413 359.712 c
87.193 359.712 87.012 359.769 86.87 359.881 c
86.827 359.913 86.727 360.028 86.567 360.224 c
86.567 358.495 l
86.035 358.495 l
h
86.567 361.735 m
86.567 361.129 86.641 360.709 86.786 360.475 c
86.914 360.27 87.104 360.167 87.358 360.167 c
87.631 360.167 87.83 360.347 87.952 360.706 c
88.042 360.972 88.086 361.311 88.086 361.721 c
88.086 362.192 88.046 362.552 87.966 362.799 c
87.848 363.168 87.636 363.352 87.33 363.352 c
87.015 363.352 86.798 363.17 86.68 362.806 c
86.604 362.568 86.567 362.211 86.567 361.735 c
f
89.388 361.819 m
89.388 362.412 89.486 362.876 89.682 363.212 c
89.911 363.604 90.268 363.8 90.753 363.8 c
91.262 363.8 91.631 363.63 91.859 363.289 c
92.069 362.972 92.174 362.477 92.174 361.805 c
92.174 361.147 92.079 360.646 91.887 360.301 c
91.668 359.899 91.313 359.699 90.823 359.699 c
90.315 359.699 89.939 359.906 89.696 360.322 c
89.491 360.676 89.388 361.175 89.388 361.819 c
h
89.962 361.805 m
89.962 361.315 90 360.961 90.074 360.741 c
90.2 360.368 90.445 360.182 90.809 360.182 c
91.15 360.182 91.379 360.373 91.495 360.755 c
91.565 360.979 91.6 361.311 91.6 361.749 c
91.6 362.216 91.561 362.566 91.481 362.799 c
91.355 363.168 91.122 363.352 90.781 363.352 c
90.436 363.352 90.2 363.156 90.074 362.764 c
90 362.535 89.962 362.216 89.962 361.805 c
h
91.005 365.067 m
91.761 365.067 l
90.858 364.08 l
90.382 364.08 l
91.005 365.067 l
f
93.035 362.008 m
92.643 361.763 l
92.643 362.365 l
93.035 362.61 l
93.035 365.074 l
93.581 365.074 l
93.581 362.946 l
94.044 363.233 l
94.044 362.631 l
93.581 362.344 l
93.581 359.811 l
93.035 359.811 l
93.035 362.008 l
f
96.06 360.755 m
96.06 361.073 96.118 361.318 96.235 361.49 c
96.333 361.639 96.489 361.754 96.704 361.833 c
97.537 362.176 l
97.616 362.204 97.696 362.234 97.775 362.267 c
97.854 362.314 97.894 362.384 97.894 362.477 c
97.894 362.883 l
97.894 363.014 97.854 363.119 97.775 363.198 c
97.672 363.301 97.52 363.352 97.32 363.352 c
97.077 363.352 96.916 363.303 96.837 363.205 c
96.758 363.107 96.718 362.927 96.718 362.666 c
96.214 362.666 l
96.214 363.072 96.311 363.365 96.504 363.544 c
96.698 363.724 96.97 363.814 97.32 363.814 c
97.796 363.814 98.116 363.681 98.279 363.415 c
98.377 363.256 98.426 363.007 98.426 362.666 c
98.426 360.574 l
98.426 360.415 98.438 360.314 98.461 360.273 c
98.484 360.231 98.533 360.205 98.608 360.195 c
98.631 360.205 98.659 360.21 98.692 360.21 c
98.725 360.21 98.75 360.21 98.769 360.21 c
98.769 359.811 l
98.426 359.783 l
98.244 359.783 98.118 359.827 98.044 359.915 c
97.972 360.004 97.936 360.151 97.936 360.356 c
97.829 360.123 97.686 359.953 97.509 359.845 c
97.364 359.757 97.196 359.712 97.005 359.712 c
96.636 359.712 96.377 359.824 96.228 360.049 c
96.116 360.216 96.06 360.452 96.06 360.755 c
h
97.852 361.917 m
97.474 361.74 97.222 361.621 97.096 361.56 c
96.788 361.411 96.634 361.157 96.634 360.797 c
96.634 360.587 96.682 360.43 96.777 360.325 c
96.873 360.22 96.995 360.167 97.145 360.167 c
97.322 360.167 97.484 360.236 97.631 360.374 c
97.778 360.512 97.852 360.688 97.852 360.902 c
97.852 361.917 l
f
99.448 359.811 m
99.448 363.709 l
100.008 363.709 l
100.008 363.268 l
100.013 363.301 100.069 363.366 100.176 363.464 c
100.433 363.697 100.682 363.814 100.925 363.814 c
101.266 363.814 101.522 363.728 101.695 363.555 c
101.868 363.382 101.954 363.109 101.954 362.736 c
101.954 359.811 l
101.394 359.811 l
101.394 362.463 l
101.394 362.771 101.368 362.981 101.317 363.093 c
101.238 363.266 101.077 363.352 100.834 363.352 c
100.601 363.352 100.405 363.277 100.246 363.128 c
100.087 362.979 100.008 362.766 100.008 362.491 c
100.008 359.811 l
99.448 359.811 l
f
103.046 360.587 m
103.046 363.24 l
102.514 363.24 l
102.514 363.709 l
103.046 363.709 l
103.046 364.759 l
103.592 364.759 l
103.592 363.709 l
104.25 363.709 l
104.25 363.24 l
103.592 363.24 l
103.592 360.525 l
103.592 360.436 103.61 360.372 103.645 360.332 c
103.68 360.292 103.753 360.273 103.865 360.273 c
104.222 360.273 l
104.222 359.811 l
103.62 359.811 l
103.368 359.811 103.205 359.873 103.13 360 c
103.074 360.093 103.046 360.289 103.046 360.587 c
f
104.558 359.048 m
104.712 358.992 104.855 358.964 104.985 358.964 c
105.149 358.964 105.287 359.023 105.402 359.142 c
105.516 359.261 105.606 359.461 105.671 359.741 c
104.425 363.709 l
104.999 363.709 l
105.888 360.314 l
106.791 363.709 l
107.365 363.709 l
106.308 360.314 l
106.103 359.68 105.991 359.337 105.972 359.286 c
105.856 358.987 105.732 358.784 105.601 358.677 c
105.526 358.621 105.433 358.575 105.321 358.54 c
105.209 358.505 105.078 358.488 104.929 358.488 c
104.85 358.488 104.783 358.491 104.73 358.498 c
104.676 358.505 104.619 358.518 104.558 358.537 c
104.558 359.048 l
f
108.142 359.811 m
108.142 363.24 l
107.568 363.24 l
107.568 363.709 l
108.142 363.709 l
108.142 364.297 l
108.142 364.586 108.24 364.799 108.436 364.934 c
108.586 365.036 108.779 365.088 109.017 365.088 c
109.304 365.088 l
109.304 364.612 l
109.031 364.612 l
108.915 364.612 108.828 364.587 108.772 364.537 c
108.716 364.487 108.688 364.382 108.688 364.221 c
108.688 363.709 l
109.304 363.709 l
109.304 363.24 l
108.688 363.24 l
108.688 359.811 l
108.142 359.811 l
f
109.78 361.819 m
109.78 362.412 109.878 362.876 110.074 363.212 c
110.303 363.604 110.66 363.8 111.145 363.8 c
111.654 363.8 112.023 363.63 112.251 363.289 c
112.461 362.972 112.567 362.477 112.567 361.805 c
112.567 361.147 112.471 360.646 112.279 360.301 c
112.06 359.899 111.705 359.699 111.215 359.699 c
110.707 359.699 110.331 359.906 110.088 360.322 c
109.883 360.676 109.78 361.175 109.78 361.819 c
h
110.354 361.805 m
110.354 361.315 110.392 360.961 110.466 360.741 c
110.592 360.368 110.837 360.182 111.201 360.182 c
111.542 360.182 111.771 360.373 111.887 360.755 c
111.957 360.979 111.992 361.311 111.992 361.749 c
111.992 362.216 111.953 362.566 111.873 362.799 c
111.747 363.168 111.514 363.352 111.173 363.352 c
110.828 363.352 110.592 363.156 110.466 362.764 c
110.392 362.535 110.354 362.216 110.354 361.805 c
f
113.224 362.764 m
113.224 363.081 113.325 363.336 113.524 363.527 c
113.724 363.718 114.013 363.814 114.394 363.814 c
114.769 363.814 115.055 363.732 115.252 363.569 c
115.477 363.382 115.59 363.081 115.59 362.666 c
115.044 362.666 l
115.044 362.909 115 363.081 114.91 363.184 c
114.82 363.287 114.662 363.338 114.436 363.338 c
114.223 363.338 114.064 363.292 113.958 363.201 c
113.852 363.111 113.799 362.988 113.799 362.834 c
113.799 362.554 113.9 362.356 114.102 362.239 c
114.181 362.192 114.394 362.103 114.737 361.97 c
115.08 361.837 115.331 361.692 115.488 361.536 c
115.645 361.38 115.724 361.182 115.724 360.944 c
115.724 360.543 115.606 360.237 115.37 360.028 c
115.134 359.818 114.816 359.712 114.415 359.712 c
113.943 359.712 113.612 359.852 113.42 360.133 c
113.29 360.324 113.224 360.595 113.224 360.944 c
113.757 360.944 l
113.757 360.697 113.796 360.515 113.875 360.398 c
113.973 360.254 114.153 360.182 114.415 360.182 c
114.648 360.182 114.829 360.234 114.957 360.339 c
115.085 360.444 115.15 360.587 115.15 360.769 c
115.15 361.003 115.084 361.171 114.952 361.273 c
114.872 361.339 114.652 361.434 114.293 361.56 c
113.933 361.686 113.695 361.798 113.577 361.896 c
113.342 362.088 113.224 362.377 113.224 362.764 c
f
116.682 359.811 m
116.682 363.24 l
116.108 363.24 l
116.108 363.709 l
116.682 363.709 l
116.682 364.297 l
116.682 364.586 116.781 364.799 116.976 364.934 c
117.126 365.036 117.319 365.088 117.558 365.088 c
117.844 365.088 l
117.844 364.612 l
117.571 364.612 l
117.455 364.612 117.368 364.587 117.313 364.537 c
117.257 364.487 117.228 364.382 117.228 364.221 c
117.228 363.709 l
117.844 363.709 l
117.844 363.24 l
117.228 363.24 l
117.228 359.811 l
116.682 359.811 l
f
118.32 361.819 m
118.32 362.412 118.419 362.876 118.615 363.212 c
118.843 363.604 119.2 363.8 119.686 363.8 c
120.194 363.8 120.563 363.63 120.792 363.289 c
121.002 362.972 121.107 362.477 121.107 361.805 c
121.107 361.147 121.011 360.646 120.82 360.301 c
120.6 359.899 120.246 359.699 119.756 359.699 c
119.247 359.699 118.871 359.906 118.629 360.322 c
118.423 360.676 118.32 361.175 118.32 361.819 c
h
118.894 361.805 m
118.894 361.315 118.932 360.961 119.006 360.741 c
119.133 360.368 119.378 360.182 119.742 360.182 c
120.082 360.182 120.311 360.373 120.428 360.755 c
120.498 360.979 120.533 361.311 120.533 361.749 c
120.533 362.216 120.493 362.566 120.414 362.799 c
120.288 363.168 120.054 363.352 119.714 363.352 c
119.368 363.352 119.133 363.156 119.006 362.764 c
118.932 362.535 118.894 362.216 118.894 361.805 c
f
121.968 365.074 0.546 -5.263 re
f
123.543 363.709 0.532 -3.899 re
123.543 364.892 0.532 -0.7 re
f
125.09 358.495 m
125.09 363.709 l
125.622 363.709 l
125.622 363.254 l
125.841 363.627 126.138 363.814 126.511 363.814 c
126.898 363.814 127.199 363.63 127.414 363.261 c
127.615 362.92 127.715 362.477 127.715 361.931 c
127.715 361.185 127.616 360.634 127.419 360.279 c
127.208 359.902 126.89 359.712 126.468 359.712 c
126.248 359.712 126.067 359.769 125.926 359.881 c
125.882 359.913 125.782 360.028 125.622 360.224 c
125.622 358.495 l
125.09 358.495 l
h
125.622 361.735 m
125.622 361.129 125.696 360.709 125.841 360.475 c
125.969 360.27 126.159 360.167 126.413 360.167 c
126.686 360.167 126.885 360.347 127.007 360.706 c
127.097 360.972 127.141 361.311 127.141 361.721 c
127.141 362.192 127.101 362.552 127.021 362.799 c
126.903 363.168 126.691 363.352 126.385 363.352 c
126.07 363.352 125.853 363.17 125.735 362.806 c
125.659 362.568 125.622 362.211 125.622 361.735 c
f
128.604 363.709 0.532 -3.899 re
128.604 364.892 0.532 -0.7 re
f
129.983 361.686 m
129.983 362.279 130.039 362.729 130.151 363.037 c
130.338 363.555 130.688 363.814 131.201 363.814 c
131.365 363.814 131.52 363.767 131.667 363.674 c
131.814 363.581 131.946 363.45 132.062 363.282 c
132.062 365.074 l
132.609 365.074 l
132.609 359.811 l
132.09 359.811 l
132.09 360.328 l
131.979 360.128 131.865 359.981 131.749 359.888 c
131.59 359.762 131.395 359.699 131.163 359.699 c
130.721 359.699 130.4 359.909 130.199 360.328 c
130.056 360.636 129.983 361.028 129.983 361.504 c
129.983 361.686 l
h
132.062 361.763 m
132.062 362.267 132.014 362.641 131.917 362.883 c
131.792 363.196 131.577 363.352 131.271 363.352 c
130.972 363.352 130.763 363.133 130.647 362.694 c
130.578 362.428 130.543 362.083 130.543 361.658 c
130.543 361.22 130.576 360.898 130.64 360.692 c
130.746 360.352 130.948 360.182 131.243 360.182 c
131.521 360.182 131.723 360.289 131.848 360.504 c
131.991 360.751 132.062 361.171 132.062 361.763 c
f
133.505 361.819 m
133.505 362.412 133.603 362.876 133.799 363.212 c
134.027 363.604 134.384 363.8 134.87 363.8 c
135.378 363.8 135.747 363.63 135.976 363.289 c
136.186 362.972 136.291 362.477 136.291 361.805 c
136.291 361.147 136.195 360.646 136.004 360.301 c
135.784 359.899 135.43 359.699 134.94 359.699 c
134.431 359.699 134.055 359.906 133.813 360.322 c
133.607 360.676 133.505 361.175 133.505 361.819 c
h
134.079 361.805 m
134.079 361.315 134.116 360.961 134.191 360.741 c
134.317 360.368 134.562 360.182 134.926 360.182 c
135.266 360.182 135.495 360.373 135.612 360.755 c
135.682 360.979 135.717 361.311 135.717 361.749 c
135.717 362.216 135.677 362.566 135.598 362.799 c
135.472 363.168 135.238 363.352 134.898 363.352 c
134.552 363.352 134.317 363.156 134.191 362.764 c
134.116 362.535 134.079 362.216 134.079 361.805 c
f
137.904 359.811 m
136.914 363.709 l
137.488 363.709 l
138.195 360.273 l
138.825 363.709 l
139.399 363.709 l
140.057 360.274 l
140.75 363.709 l
141.324 363.709 l
140.358 359.811 l
139.77 359.811 l
139.098 363.239 l
138.477 359.812 l
137.904 359.811 l
f
141.625 359.048 m
141.779 358.992 141.921 358.964 142.052 358.964 c
142.215 358.964 142.354 359.023 142.469 359.142 c
142.583 359.261 142.673 359.461 142.738 359.741 c
141.492 363.709 l
142.066 363.709 l
142.955 360.314 l
143.858 363.709 l
144.432 363.709 l
143.375 360.314 l
143.17 359.68 143.058 359.337 143.039 359.286 c
142.922 358.987 142.799 358.784 142.668 358.677 c
142.593 358.621 142.5 358.575 142.388 358.54 c
142.276 358.505 142.145 358.488 141.996 358.488 c
141.917 358.488 141.85 358.491 141.796 358.498 c
141.743 358.505 141.686 358.518 141.625 358.537 c
141.625 359.048 l
f
1 g
0.5 w
67.733 372.167 m
68.67 372.167 69.434 371.402 69.434 370.466 c
69.434 369.529 68.67 368.765 67.733 368.765 c
66.796 368.765 66.032 369.529 66.032 370.466 c
66.032 371.402 66.796 372.167 67.733 372.167 c
b*
0 g
210.437 372.664 0.588 -5.249 re
f
212.194 367.415 m
212.194 371.313 l
212.754 371.313 l
212.754 370.872 l
212.759 370.905 212.815 370.97 212.922 371.068 c
213.179 371.302 213.428 371.418 213.671 371.418 c
214.012 371.418 214.268 371.332 214.441 371.159 c
214.614 370.987 214.7 370.714 214.7 370.34 c
214.7 367.415 l
214.14 367.415 l
214.14 370.067 l
214.14 370.376 214.114 370.585 214.063 370.697 c
213.984 370.87 213.823 370.956 213.58 370.956 c
213.347 370.956 213.151 370.882 212.992 370.732 c
212.833 370.583 212.754 370.371 212.754 370.096 c
212.754 367.415 l
212.194 367.415 l
f
215.708 367.429 m
215.708 372.678 l
216.268 372.678 l
216.268 370.9 l
216.352 371.045 216.492 371.167 216.688 371.268 c
216.884 371.368 217.087 371.418 217.297 371.418 c
217.563 371.418 217.773 371.341 217.927 371.187 c
218.109 371.01 218.2 370.737 218.2 370.368 c
218.2 367.429 l
217.64 367.429 l
217.64 370.124 l
217.64 370.399 217.605 370.599 217.535 370.725 c
217.451 370.879 217.302 370.956 217.087 370.956 c
216.854 370.956 216.659 370.881 216.503 370.729 c
216.346 370.577 216.268 370.357 216.268 370.067 c
216.268 367.429 l
215.708 367.429 l
f
218.991 369.312 m
218.991 369.825 219.054 370.249 219.179 370.585 c
219.388 371.141 219.743 371.418 220.244 371.418 c
220.731 371.418 221.068 371.229 221.254 370.851 c
221.378 370.595 221.442 370.21 221.442 369.696 c
221.442 369.312 l
219.565 369.312 l
219.551 369.122 l
219.551 368.74 219.586 368.448 219.656 368.248 c
219.764 367.94 219.957 367.786 220.237 367.786 c
220.527 367.786 220.723 367.9 220.826 368.129 c
220.886 368.264 220.917 368.46 220.917 368.717 c
221.442 368.717 l
221.442 368.283 221.346 367.947 221.154 367.709 c
220.94 367.438 220.634 367.303 220.237 367.303 c
219.729 367.303 219.374 367.562 219.173 368.08 c
219.052 368.397 218.991 368.808 218.991 369.312 c
h
220.867 369.766 m
220.867 370.228 220.812 370.542 220.703 370.708 c
220.593 370.874 220.443 370.956 220.251 370.956 c
220.041 370.956 219.878 370.875 219.761 370.711 c
219.621 370.511 219.551 370.196 219.551 369.766 c
220.867 369.766 l
f
222.365 367.415 m
222.365 371.327 l
222.883 371.327 l
222.883 370.655 l
223.009 370.903 223.142 371.075 223.282 371.173 c
223.46 371.299 223.714 371.362 224.045 371.362 c
224.045 370.789 l
223.961 370.802 223.908 370.811 223.885 370.813 c
223.861 370.815 223.819 370.816 223.758 370.816 c
223.497 370.816 223.291 370.72 223.139 370.526 c
222.987 370.332 222.911 370.056 222.911 369.696 c
222.911 367.415 l
222.365 367.415 l
f
224.633 371.313 0.532 -3.899 re
224.633 372.496 0.532 -0.7 re
f
226.279 368.192 m
226.279 370.844 l
225.747 370.844 l
225.747 371.313 l
226.279 371.313 l
226.279 372.363 l
226.825 372.363 l
226.825 371.313 l
227.483 371.313 l
227.483 370.844 l
226.825 370.844 l
226.825 368.129 l
226.825 368.04 226.842 367.976 226.877 367.936 c
226.912 367.897 226.986 367.877 227.098 367.877 c
227.455 367.877 l
227.455 367.415 l
226.853 367.415 l
226.601 367.415 226.437 367.478 226.363 367.604 c
226.306 367.697 226.279 367.893 226.279 368.192 c
f
227.917 369.312 m
227.917 369.825 227.98 370.249 228.104 370.585 c
228.313 371.141 228.668 371.418 229.17 371.418 c
229.656 371.418 229.993 371.229 230.179 370.851 c
230.304 370.595 230.367 370.21 230.367 369.696 c
230.367 369.312 l
228.491 369.312 l
228.477 369.122 l
228.477 368.74 228.512 368.448 228.582 368.248 c
228.689 367.94 228.883 367.786 229.163 367.786 c
229.452 367.786 229.648 367.9 229.751 368.129 c
229.811 368.264 229.842 368.46 229.842 368.717 c
230.367 368.717 l
230.367 368.283 230.271 367.947 230.08 367.709 c
229.865 367.438 229.559 367.303 229.163 367.303 c
228.654 367.303 228.299 367.562 228.099 368.08 c
227.977 368.397 227.917 368.808 227.917 369.312 c
h
229.793 369.766 m
229.793 370.228 229.738 370.542 229.628 370.708 c
229.519 370.874 229.368 370.956 229.177 370.956 c
228.967 370.956 228.803 370.875 228.687 370.711 c
228.547 370.511 228.477 370.196 228.477 369.766 c
229.793 369.766 l
f
231.053 369.291 m
231.053 369.883 231.109 370.333 231.221 370.641 c
231.407 371.159 231.757 371.418 232.271 371.418 c
232.434 371.418 232.589 371.372 232.736 371.278 c
232.883 371.185 233.015 371.054 233.132 370.886 c
233.132 372.678 l
233.678 372.678 l
233.678 367.415 l
233.16 367.415 l
233.16 367.933 l
233.048 367.732 232.935 367.585 232.818 367.492 c
232.659 367.366 232.464 367.303 232.232 367.303 c
231.79 367.303 231.469 367.513 231.269 367.933 c
231.125 368.241 231.053 368.633 231.053 369.109 c
231.053 369.291 l
h
233.132 369.368 m
233.132 369.872 233.083 370.245 232.986 370.487 c
232.861 370.8 232.646 370.956 232.341 370.956 c
232.041 370.956 231.832 370.737 231.716 370.298 c
231.648 370.033 231.613 369.687 231.613 369.263 c
231.613 368.824 231.645 368.502 231.709 368.297 c
231.816 367.956 232.018 367.786 232.313 367.786 c
232.59 367.786 232.792 367.893 232.917 368.108 c
233.06 368.355 233.132 368.775 233.132 369.368 c
f
236.569 368.192 m
236.569 370.844 l
236.037 370.844 l
236.037 371.313 l
236.569 371.313 l
236.569 372.363 l
237.115 372.363 l
237.115 371.313 l
237.773 371.313 l
237.773 370.844 l
237.115 370.844 l
237.115 368.129 l
237.115 368.04 237.133 367.976 237.168 367.936 c
237.202 367.897 237.276 367.877 237.388 367.877 c
237.745 367.877 l
237.745 367.415 l
237.143 367.415 l
236.891 367.415 236.728 367.478 236.653 367.604 c
236.597 367.697 236.569 367.893 236.569 368.192 c
f
238.424 367.429 m
238.424 372.678 l
238.984 372.678 l
238.984 370.9 l
239.068 371.045 239.208 371.167 239.404 371.268 c
239.6 371.368 239.803 371.418 240.013 371.418 c
240.279 371.418 240.489 371.341 240.643 371.187 c
240.825 371.01 240.916 370.737 240.916 370.368 c
240.916 367.429 l
240.356 367.429 l
240.356 370.124 l
240.356 370.399 240.321 370.599 240.251 370.725 c
240.167 370.879 240.018 370.956 239.803 370.956 c
239.57 370.956 239.375 370.881 239.219 370.729 c
239.062 370.577 238.984 370.357 238.984 370.067 c
238.984 367.429 l
238.424 367.429 l
f
241.98 367.415 m
241.98 371.327 l
242.498 371.327 l
242.498 370.655 l
242.624 370.903 242.757 371.075 242.897 371.173 c
243.075 371.299 243.329 371.362 243.66 371.362 c
243.66 370.789 l
243.576 370.802 243.523 370.811 243.5 370.813 c
243.476 370.815 243.434 370.816 243.373 370.816 c
243.112 370.816 242.906 370.72 242.754 370.526 c
242.602 370.332 242.526 370.056 242.526 369.696 c
242.526 367.415 l
241.98 367.415 l
f
244.087 369.424 m
244.087 370.016 244.185 370.48 244.382 370.816 c
244.61 371.208 244.967 371.404 245.453 371.404 c
245.961 371.404 246.33 371.234 246.558 370.893 c
246.768 370.576 246.874 370.081 246.874 369.41 c
246.874 368.752 246.778 368.25 246.586 367.905 c
246.367 367.504 246.012 367.303 245.523 367.303 c
245.014 367.303 244.638 367.51 244.395 367.926 c
244.19 368.28 244.087 368.78 244.087 369.424 c
h
244.661 369.41 m
244.661 368.92 244.699 368.565 244.773 368.346 c
244.899 367.972 245.144 367.786 245.508 367.786 c
245.849 367.786 246.078 367.977 246.194 368.36 c
246.264 368.584 246.3 368.915 246.3 369.354 c
246.3 369.82 246.26 370.17 246.18 370.403 c
246.054 370.772 245.821 370.956 245.481 370.956 c
245.135 370.956 244.899 370.76 244.773 370.368 c
244.699 370.14 244.661 369.82 244.661 369.41 c
f
247.763 367.415 m
247.763 371.313 l
248.294 371.313 l
248.294 370.802 l
248.407 370.994 248.55 371.144 248.725 371.254 c
248.9 371.364 249.076 371.418 249.254 371.418 c
249.45 371.418 249.622 371.368 249.772 371.268 c
249.921 371.167 250.049 371.008 250.157 370.789 c
250.287 370.984 250.437 371.138 250.605 371.25 c
250.773 371.362 250.964 371.418 251.179 371.418 c
251.571 371.418 251.846 371.281 252.005 371.005 c
252.103 370.837 252.152 370.625 252.152 370.368 c
252.152 367.415 l
251.606 367.415 l
251.606 370.298 l
251.606 370.471 251.58 370.604 251.529 370.697 c
251.44 370.861 251.274 370.942 251.032 370.942 c
250.794 370.942 250.607 370.877 250.472 370.746 c
250.318 370.597 250.241 370.371 250.241 370.067 c
250.241 367.415 l
249.681 367.415 l
249.681 370.151 l
249.681 370.422 249.646 370.616 249.574 370.732 c
249.489 370.872 249.339 370.942 249.122 370.942 c
248.905 370.942 248.726 370.886 248.585 370.774 c
248.391 370.62 248.294 370.385 248.294 370.067 c
248.294 367.415 l
247.763 367.415 l
f
253.202 367.415 m
253.202 372.678 l
253.748 372.678 l
253.748 370.914 l
253.864 371.087 253.987 371.214 254.115 371.296 c
254.244 371.377 254.392 371.418 254.56 371.418 c
254.975 371.418 255.286 371.258 255.491 370.939 c
255.696 370.619 255.799 370.151 255.799 369.535 c
255.799 368.77 255.701 368.209 255.505 367.852 c
255.309 367.495 255.001 367.317 254.581 367.317 c
254.217 367.317 253.925 367.504 253.706 367.877 c
253.706 367.415 l
253.202 367.415 l
h
253.706 369.249 m
253.706 368.717 253.768 368.337 253.891 368.111 c
254.015 367.885 254.219 367.772 254.504 367.772 c
254.793 367.772 254.996 367.954 255.113 368.318 c
255.188 368.556 255.225 368.871 255.225 369.263 c
255.225 369.522 l
255.225 369.965 255.167 370.315 255.05 370.571 c
254.933 370.828 254.756 370.956 254.518 370.956 c
254.163 370.956 253.928 370.763 253.811 370.376 c
253.741 370.142 253.706 369.766 253.706 369.249 c
f
256.527 369.424 m
256.527 370.016 256.625 370.48 256.821 370.816 c
257.05 371.208 257.407 371.404 257.892 371.404 c
258.401 371.404 258.77 371.234 258.998 370.893 c
259.208 370.576 259.313 370.081 259.313 369.41 c
259.313 368.752 259.217 368.25 259.026 367.905 c
258.807 367.504 258.452 367.303 257.962 367.303 c
257.453 367.303 257.078 367.51 256.835 367.926 c
256.63 368.28 256.527 368.78 256.527 369.424 c
h
257.101 369.41 m
257.101 368.92 257.138 368.565 257.213 368.346 c
257.339 367.972 257.584 367.786 257.948 367.786 c
258.289 367.786 258.518 367.977 258.634 368.36 c
258.704 368.584 258.739 368.915 258.739 369.354 c
258.739 369.82 258.7 370.17 258.62 370.403 c
258.494 370.772 258.261 370.956 257.92 370.956 c
257.575 370.956 257.339 370.76 257.213 370.368 c
257.138 370.14 257.101 369.82 257.101 369.41 c
f
260.174 366.099 m
260.174 371.313 l
260.706 371.313 l
260.706 370.858 l
260.925 371.232 261.222 371.418 261.595 371.418 c
261.983 371.418 262.284 371.234 262.498 370.865 c
262.699 370.525 262.799 370.081 262.799 369.535 c
262.799 368.789 262.7 368.238 262.503 367.884 c
262.292 367.506 261.974 367.317 261.552 367.317 c
261.332 367.317 261.151 367.373 261.01 367.485 c
260.967 367.517 260.866 367.632 260.706 367.828 c
260.706 366.099 l
260.174 366.099 l
h
260.706 369.34 m
260.706 368.733 260.78 368.313 260.925 368.08 c
261.053 367.875 261.243 367.772 261.497 367.772 c
261.77 367.772 261.969 367.951 262.091 368.311 c
262.181 368.577 262.225 368.915 262.225 369.325 c
262.225 369.797 262.186 370.156 262.105 370.403 c
261.987 370.772 261.775 370.956 261.469 370.956 c
261.154 370.956 260.937 370.774 260.819 370.41 c
260.743 370.172 260.706 369.815 260.706 369.34 c
f
263.688 367.429 m
263.688 372.678 l
264.249 372.678 l
264.249 370.9 l
264.332 371.045 264.472 371.167 264.669 371.268 c
264.865 371.368 265.067 371.418 265.278 371.418 c
265.543 371.418 265.754 371.341 265.907 371.187 c
266.089 371.01 266.18 370.737 266.18 370.368 c
266.18 367.429 l
265.621 367.429 l
265.621 370.124 l
265.621 370.399 265.585 370.599 265.515 370.725 c
265.431 370.879 265.282 370.956 265.067 370.956 c
264.834 370.956 264.639 370.881 264.483 370.729 c
264.327 370.577 264.249 370.357 264.249 370.067 c
264.249 367.429 l
263.688 367.429 l
f
267.189 371.313 0.532 -3.899 re
267.189 372.496 0.532 -0.7 re
f
268.736 372.678 0.546 -5.263 re
f
270.311 371.313 0.532 -3.899 re
270.311 372.496 0.532 -0.7 re
f
271.571 368.36 m
271.571 368.677 271.629 368.922 271.746 369.095 c
271.844 369.244 272 369.358 272.215 369.438 c
273.048 369.781 l
273.128 369.808 273.207 369.839 273.286 369.872 c
273.365 369.918 273.405 369.988 273.405 370.081 c
273.405 370.487 l
273.405 370.618 273.365 370.723 273.286 370.802 c
273.183 370.905 273.032 370.956 272.831 370.956 c
272.588 370.956 272.427 370.907 272.348 370.809 c
272.269 370.711 272.229 370.532 272.229 370.27 c
271.725 370.27 l
271.725 370.676 271.822 370.969 272.016 371.149 c
272.209 371.328 272.481 371.418 272.831 371.418 c
273.307 371.418 273.627 371.285 273.79 371.019 c
273.888 370.861 273.937 370.611 273.937 370.27 c
273.937 368.178 l
273.937 368.019 273.949 367.919 273.972 367.877 c
273.996 367.835 274.045 367.809 274.119 367.8 c
274.142 367.809 274.171 367.814 274.203 367.814 c
274.236 367.814 274.262 367.814 274.28 367.814 c
274.28 367.415 l
273.937 367.387 l
273.755 367.387 273.629 367.431 273.556 367.52 c
273.483 367.608 273.447 367.756 273.447 367.961 c
273.34 367.727 273.198 367.557 273.02 367.45 c
272.876 367.361 272.707 367.317 272.516 367.317 c
272.148 367.317 271.888 367.429 271.739 367.653 c
271.627 367.821 271.571 368.057 271.571 368.36 c
h
273.363 369.522 m
272.985 369.344 272.733 369.225 272.607 369.165 c
272.299 369.015 272.145 368.761 272.145 368.402 c
272.145 368.192 272.193 368.034 272.289 367.929 c
272.384 367.824 272.507 367.772 272.656 367.772 c
272.834 367.772 272.996 367.841 273.143 367.978 c
273.29 368.116 273.363 368.292 273.363 368.507 c
273.363 369.522 l
f
210.997 359.205 m
209.863 364.468 l
210.514 364.468 l
211.244 360.584 l
211.36 359.634 l
211.489 360.584 l
212.306 364.468 l
213.04 364.469 l
213.772 360.612 l
213.881 359.605 l
214.014 360.612 l
214.826 364.468 l
215.463 364.468 l
214.238 359.205 l
213.51 359.205 l
212.752 363.168 l
212.649 364.042 l
212.551 363.167 l
211.704 359.205 l
210.997 359.205 l
f
216.149 359.205 m
216.149 363.118 l
216.667 363.118 l
216.667 362.446 l
216.793 362.693 216.926 362.866 217.066 362.964 c
217.243 363.089 217.498 363.152 217.829 363.152 c
217.829 362.579 l
217.745 362.593 217.692 362.601 217.668 362.603 c
217.645 362.605 217.603 362.607 217.542 362.607 c
217.281 362.607 217.074 362.51 216.923 362.316 c
216.771 362.122 216.695 361.846 216.695 361.487 c
216.695 359.205 l
216.149 359.205 l
f
218.256 361.214 m
218.256 361.806 218.354 362.271 218.55 362.607 c
218.779 362.998 219.136 363.195 219.621 363.195 c
220.13 363.195 220.499 363.024 220.727 362.684 c
220.937 362.366 221.042 361.872 221.042 361.2 c
221.042 360.542 220.947 360.04 220.755 359.695 c
220.536 359.294 220.181 359.093 219.691 359.093 c
219.182 359.093 218.807 359.301 218.564 359.716 c
218.359 360.071 218.256 360.57 218.256 361.214 c
h
218.83 361.2 m
218.83 360.71 218.867 360.355 218.942 360.136 c
219.068 359.763 219.313 359.576 219.677 359.576 c
220.018 359.576 220.247 359.767 220.363 360.15 c
220.433 360.374 220.468 360.705 220.468 361.144 c
220.468 361.611 220.429 361.96 220.349 362.194 c
220.223 362.562 219.99 362.747 219.649 362.747 c
219.304 362.747 219.068 362.551 218.942 362.159 c
218.867 361.93 218.83 361.611 218.83 361.2 c
f
221.735 361.081 m
221.735 361.673 221.791 362.124 221.903 362.432 c
222.09 362.949 222.44 363.208 222.953 363.208 c
223.117 363.208 223.272 363.162 223.419 363.068 c
223.566 362.975 223.698 362.845 223.814 362.677 c
223.814 364.468 l
224.361 364.468 l
224.361 359.205 l
223.842 359.205 l
223.842 359.723 l
223.73 359.522 223.617 359.375 223.5 359.282 c
223.342 359.156 223.147 359.093 222.915 359.093 c
222.473 359.093 222.152 359.303 221.951 359.723 c
221.807 360.031 221.735 360.423 221.735 360.899 c
221.735 361.081 l
h
223.814 361.158 m
223.814 361.662 223.766 362.035 223.669 362.278 c
223.544 362.59 223.329 362.747 223.023 362.747 c
222.723 362.747 222.515 362.527 222.399 362.089 c
222.33 361.823 222.295 361.477 222.295 361.053 c
222.295 360.614 222.328 360.292 222.392 360.087 c
222.498 359.746 222.7 359.576 222.995 359.576 c
223.273 359.576 223.475 359.683 223.6 359.898 c
223.743 360.145 223.814 360.565 223.814 361.158 c
f
225.074 359.666 m
226.864 362.648 l
225.142 362.648 l
225.142 363.104 l
227.452 363.104 l
227.452 362.648 l
225.646 359.667 l
227.466 359.667 l
227.466 359.219 l
225.072 359.219 l
225.074 359.666 l
f
227.98 361.214 m
227.98 361.806 228.078 362.271 228.274 362.607 c
228.502 362.998 228.859 363.195 229.345 363.195 c
229.853 363.195 230.222 363.024 230.451 362.684 c
230.661 362.366 230.766 361.872 230.766 361.2 c
230.766 360.542 230.67 360.04 230.479 359.695 c
230.259 359.294 229.905 359.093 229.415 359.093 c
228.906 359.093 228.53 359.301 228.288 359.716 c
228.082 360.071 227.98 360.57 227.98 361.214 c
h
228.554 361.2 m
228.554 360.71 228.591 360.355 228.666 360.136 c
228.792 359.763 229.037 359.576 229.401 359.576 c
229.741 359.576 229.97 359.767 230.087 360.15 c
230.157 360.374 230.192 360.705 230.192 361.144 c
230.192 361.611 230.152 361.96 230.073 362.194 c
229.947 362.562 229.713 362.747 229.373 362.747 c
229.027 362.747 228.792 362.551 228.666 362.159 c
228.591 361.93 228.554 361.611 228.554 361.2 c
f
231.627 359.205 m
231.627 363.104 l
232.187 363.104 l
232.187 362.663 l
232.192 362.695 232.248 362.761 232.355 362.858 c
232.612 363.092 232.861 363.208 233.104 363.208 c
233.445 363.208 233.701 363.122 233.874 362.949 c
234.047 362.777 234.133 362.504 234.133 362.131 c
234.133 359.205 l
233.573 359.205 l
233.573 361.858 l
233.573 362.166 233.547 362.376 233.496 362.487 c
233.417 362.66 233.256 362.747 233.013 362.747 c
232.78 362.747 232.584 362.672 232.425 362.523 c
232.266 362.373 232.187 362.161 232.187 361.886 c
232.187 359.205 l
231.627 359.205 l
f
234.84 360.15 m
234.84 360.467 234.898 360.712 235.015 360.885 c
235.113 361.034 235.269 361.149 235.484 361.228 c
236.317 361.571 l
236.397 361.599 236.476 361.629 236.555 361.662 c
236.634 361.708 236.674 361.778 236.674 361.872 c
236.674 362.278 l
236.674 362.408 236.634 362.513 236.555 362.593 c
236.452 362.695 236.301 362.747 236.1 362.747 c
235.857 362.747 235.696 362.697 235.617 362.6 c
235.538 362.502 235.498 362.322 235.498 362.061 c
234.994 362.061 l
234.994 362.466 235.091 362.759 235.285 362.939 c
235.478 363.119 235.75 363.208 236.1 363.208 c
236.576 363.208 236.896 363.076 237.059 362.809 c
237.157 362.651 237.206 362.401 237.206 362.061 c
237.206 359.968 l
237.206 359.809 237.218 359.709 237.241 359.667 c
237.265 359.625 237.314 359.599 237.388 359.59 c
237.411 359.599 237.439 359.604 237.472 359.604 c
237.505 359.604 237.53 359.604 237.549 359.604 c
237.549 359.205 l
237.206 359.177 l
237.024 359.177 236.898 359.222 236.825 359.31 c
236.752 359.399 236.716 359.546 236.716 359.751 c
236.609 359.518 236.467 359.347 236.289 359.24 c
236.145 359.152 235.976 359.107 235.785 359.107 c
235.417 359.107 235.157 359.219 235.008 359.443 c
234.896 359.611 234.84 359.847 234.84 360.15 c
h
236.632 361.312 m
236.254 361.134 236.002 361.016 235.876 360.955 c
235.568 360.806 235.414 360.551 235.414 360.192 c
235.414 359.982 235.462 359.824 235.558 359.72 c
235.653 359.615 235.776 359.562 235.925 359.562 c
236.103 359.562 236.265 359.631 236.412 359.769 c
236.559 359.906 236.632 360.082 236.632 360.297 c
236.632 361.312 l
f
240.076 359.982 m
240.076 362.635 l
239.544 362.635 l
239.544 363.104 l
240.076 363.104 l
240.076 364.153 l
240.622 364.153 l
240.622 363.104 l
241.28 363.104 l
241.28 362.635 l
240.622 362.635 l
240.622 359.919 l
240.622 359.83 240.64 359.766 240.675 359.727 c
240.71 359.687 240.783 359.667 240.895 359.667 c
241.252 359.667 l
241.252 359.205 l
240.651 359.205 l
240.399 359.205 240.235 359.268 240.16 359.394 c
240.104 359.487 240.076 359.683 240.076 359.982 c
f
241.987 359.205 m
241.987 363.118 l
242.505 363.118 l
242.505 362.446 l
242.632 362.693 242.764 362.866 242.905 362.964 c
243.082 363.089 243.336 363.152 243.667 363.152 c
243.667 362.579 l
243.583 362.593 243.53 362.601 243.507 362.603 c
243.483 362.605 243.441 362.607 243.381 362.607 c
243.119 362.607 242.913 362.51 242.761 362.316 c
242.609 362.122 242.533 361.846 242.533 361.487 c
242.533 359.205 l
241.987 359.205 l
f
244.094 361.214 m
244.094 361.806 244.192 362.271 244.389 362.607 c
244.617 362.998 244.974 363.195 245.46 363.195 c
245.968 363.195 246.337 363.024 246.565 362.684 c
246.776 362.366 246.881 361.872 246.881 361.2 c
246.881 360.542 246.785 360.04 246.594 359.695 c
246.374 359.294 246.019 359.093 245.53 359.093 c
245.021 359.093 244.645 359.301 244.402 359.716 c
244.197 360.071 244.094 360.57 244.094 361.214 c
h
244.668 361.2 m
244.668 360.71 244.706 360.355 244.78 360.136 c
244.907 359.763 245.151 359.576 245.515 359.576 c
245.856 359.576 246.085 359.767 246.201 360.15 c
246.271 360.374 246.307 360.705 246.307 361.144 c
246.307 361.611 246.267 361.96 246.188 362.194 c
246.061 362.562 245.828 362.747 245.488 362.747 c
245.142 362.747 244.907 362.551 244.78 362.159 c
244.706 361.93 244.668 361.611 244.668 361.2 c
f
247.77 359.205 m
247.77 363.104 l
248.302 363.104 l
248.302 362.593 l
248.414 362.784 248.557 362.934 248.732 363.044 c
248.907 363.154 249.083 363.208 249.261 363.208 c
249.457 363.208 249.629 363.158 249.779 363.058 c
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251.613 359.205 l
251.613 362.089 l
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249.688 359.205 l
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248.302 359.205 l
247.77 359.205 l
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253.713 359.205 l
253.209 359.205 l
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255.195 360.346 255.232 360.661 255.232 361.053 c
255.232 361.312 l
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253.748 361.932 253.713 361.557 253.713 361.039 c
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256.637 360.071 256.534 360.57 256.534 361.214 c
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258.296 359.576 258.525 359.767 258.641 360.15 c
258.711 360.374 258.746 360.705 258.746 361.144 c
258.746 361.611 258.707 361.96 258.627 362.194 c
258.501 362.562 258.268 362.747 257.927 362.747 c
257.582 362.747 257.346 362.551 257.22 362.159 c
257.145 361.93 257.108 361.611 257.108 361.2 c
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259.901 362.635 l
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260.475 363.104 l
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265.397 363.104 0.532 -3.899 re
265.397 364.286 0.532 -0.7 re
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(Acta Angiol., 2004, Vol. 10, No. 1)Tj
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(www.angiologia.pl)Tj
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(tients with inherited thrombophilia F1+2 levels rema-)Tj
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(Discussion)Tj
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(The sensitivity of Polish rabbit brain thromboplastin)Tj
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[(reagent )5.9(\(Biomed,)-21.1( )-20.6(WSS, Warsaw\) to the presence of a lu-)]TJ
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-0.0204 Tc
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(pus anticoagulant has not as yet been studied. The present)Tj
0 -1.4433 TD
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(study demonstrates, that Polish thromboplastin reagent)Tj
T*
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0.0222 Tw
(like Thromborel S \(Dade Behring, Marburg, Germany\) is)Tj
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(not sensitive to LA and may be used for prothrombin time)Tj
0 -1.4433 TD
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(measurement in patients with lupus anticoagulant.)Tj
1.5733 -1.4433 TD
0.0099 Tc
-0.0518 Tw
(Treatment of acute thrombotic event, if identified,)Tj
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(is no different in APS than in the general population.)Tj
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(Due to high of risk of recurrent thrombosis in patients)Tj
T*
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(with APS, after initial treatment with heparin a long-)Tj
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(term, if not life-long, antithrombotic prophylaxis with)Tj
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[(oral anticoagulants should be applied [3)5.2(6, 13, 14]. Ho-)]TJ
T*
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(wever, the optimal intensity of oral anticoagulant tre-)Tj
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(atment in patients with the antiphospholipid antibody)Tj
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(syndrome remains controversial. The issue is impor-)Tj
T*
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0.0898 Tw
(tant, since high-intensity anticoagulation carries a hi-)Tj
0 -1.4467 TD
0.0096 Tc
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(gher risk of hemorrhagic complications. Prandoni et)Tj
0 -1.4433 TD
0.009 Tc
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(al. [4] followed-up 21 patients with APS receiving war-)Tj
T*
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0.1361 Tw
(farin after VTE episode and during the initial three-)Tj
0 -1.4467 TD
0.0102 Tc
0.1184 Tw
[(month period of anticoagulation \(INR 2.0)9.2(3.0\), only)]TJ
0 -1.4433 TD
0.0097 Tc
-0.0694 Tw
(one patient experienced thrombotic recurrence in the)Tj
T*
0.0208 Tc
0.1389 Tw
(targeted INR range. Three minor bleedings, which)Tj
0 -1.4467 TD
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(ocurred during follow-up, did not require interruption)Tj
0 -1.4433 TD
0.01 Tc
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(of anticoagulation. Among 70 patients with APS, war-)Tj
T*
0.0084 Tc
-0.0694 Tw
[(farin treatment of intermediate intensity \(INR 2.0)-4.9()14.1(2.9\))]TJ
0 -1.4467 TD
0.0099 Tc
-0.0695 Tw
(and high intensity \(INR )Tj
/F6 1 Tf
10.29 0 TD
0 Tc
0 Tw
()Tj
/F2 1 Tf
0.8433 0 TD
0.0095 Tc
-0.0695 Tw
[( 3.0\) significantly reduced the)]TJ
-11.1333 -1.4433 TD
0.0098 Tc
0.1177 Tw
(rate of recurrent thrombosis, whereas low-intensity)Tj
T*
0.0096 Tc
0.0361 Tw
(treatment \(INR )Tj
/F6 1 Tf
7.3133 0 TD
0 Tc
0 Tw
()Tj
/F2 1 Tf
0.8433 0 TD
0.0102 Tc
0.037 Tw
[( 1.9\) did not confer significant pro-)]TJ
-8.1567 -1.4467 TD
0.0097 Tc
0.1341 Tw
(tection [6]. Kamashta et al. [3] recommended high-)Tj
0 -1.4433 TD
-0.0197 Tc
0.1388 Tw
[(intensity anticoagulation with INRs of 3.0 or higher )-6.5(f)-33(o)-33(r)]TJ
T*
0.0097 Tc
0.0871 Tw
(patients with APS and thrombotic events. However,)Tj
0 -1.4467 TD
0.0102 Tc
-0.0525 Tw
(in 7 out of 64 patients on high-intensity warfarin treat-)Tj
0 -1.4433 TD
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0 Tw
(ment, severe bleeding complications ocurred. In con-)Tj
T*
0.0639 Tw
(trast, Ginsberg et al. [15] and Rance et al. [5] sugge-)Tj
0 -1.4467 TD
0.0548 Tw
[(sted that an INR of 2.0)8.9(3.0 was sufficient to prevent)]TJ
0 -1.4433 TD
0.0095 Tc
-0.0014 Tw
(VTE recurrences in APS patients.)Tj
1.5733 -1.4433 TD
-0.0102 Tc
0.0313 Tw
(In the present study, 21 patients with APS receiving)Tj
-1.5733 -1.4467 TD
-0.0101 Tc
0.0769 Tw
[(acenocoumarol with targeted INR 2.0)-11.1(3.0, were follo-)]TJ
0 -1.4433 TD
0.0098 Tc
0.1122 Tw
(wed up for 3 to 8 years \(total length of prophylaxis)Tj
T*
0.0065 Tc
-0.0686 Tw
( 95 years\). )Tj
5.8733 0 TD
-0.013 Tc
-0.0685 Tw
(During maintenance treatment, prothrom-)Tj
-5.8733 -1.4467 TD
-0.0107 Tc
-0.0356 Tw
(bin time tests were repeated at least every 4 weeks, and)Tj
0 -1.4433 TD
-0.0098 Tc
-0.0339 Tw
[(the INR value was maintained within 2.0)-10.8(3.0 for 70% of)]TJ
T*
0.0257 Tw
(observation time. In the follow-up period only one APS)Tj
0 -1.4467 TD
-0.0103 Tc
-0.0421 Tw
(patient developed a recurrent episode of venous throm-)Tj
0 -1.4433 TD
0.0047 Tw
(bosis. The patient stopped taking acenocoumarol 3 we-)Tj
T*
-0.0107 Tc
-0.025 Tw
(eks before the recurrence. After the restart of acenoco-)Tj
0 -1.4467 TD
-0.0102 Tc
-0.0132 Tw
[(umarol \(INR 2.0)-11.2(3.0\) he had no further thrombosis epi-)]TJ
26.6167 73.6667 TD
0.0165 Tc
-0.0694 Tw
(na due ryzyko wystpienia nawrotw zakrzepicy, po)Tj
0 -1.4433 TD
0.0172 Tc
0.0444 Tw
(wstpnej terapii heparyn, pacjenci z APS wymagaj)Tj
T*
0.0225 Tc
0.1389 Tw
(dugotrwaej \(najczciej trwajcej do koca ycia\))Tj
0 -1.4467 TD
0.006 Tc
-0.0694 Tw
(profilaktyki przeciwzakrzepowej z zastosowaniem do-)Tj
0 -1.4433 TD
0.0182 Tc
0.0377 Tw
[(ustnego antykoagulantu [3)17.2(6, 13, 14]. Kontrowersje)]TJ
T*
0.0175 Tc
0 Tw
(natomiast )Tj
4.7633 0 TD
-0.0012 Tc
[(wzbudza )]TJ
4.2274 0 TD
0.0182 Tc
-0.0111 Tw
(intensywno wtrnej profilakty-)Tj
-8.9908 -1.4467 TD
0.0175 Tc
0.1016 Tw
(ki przeciwzakrzepowej u tych chorych. Jest to bar-)Tj
0 -1.4433 TD
0.0101 Tc
-0.0685 Tw
(dzo wane zagadnienie, )Tj
10.7733 0 TD
-0.0076 Tc
0 Tw
[(poniewa)-17.6( )]TJ
4.4293 0 TD
0.01 Tc
-0.0694 Tw
(intensyfikacja lecze-)Tj
-15.2026 -1.4433 TD
0.0171 Tc
0.0708 Tw
(nia przeciwzakrzepowego prowadzi do zwikszenia)Tj
0 -1.4467 TD
0.0177 Tc
-0.0222 Tw
(ryzyka wystpienia powika krwotocznych. Prando-)Tj
0 -1.4433 TD
-0.0066 Tc
-0.0694 Tw
(ni i wsp. [4] stwierdzili nawrt zakrzepicy tylko u 1 spo-)Tj
T*
0 Tc
-0.05 Tw
[(rd 21)-17.6( )]TJ
3.1672 0 TD
0.0176 Tc
(pacjentw z APS, otrzymujcych przez pierw-)Tj
-3.1672 -1.4467 TD
0.0169 Tc
-0.0689 Tw
(sze 3 miesice wtrnej profilaktyki przeciwzakrzepo-)Tj
0 -1.4433 TD
0.0171 Tc
0.1345 Tw
(wej warfaryn w dawkach pozwalajcych utrzyma)Tj
T*
0.0264 Tc
0.1388 Tw
[(warto INR w granicach 2,0)12.1(3)-0.4(,0. Trzy niewielkie)]TJ
0 -1.4467 TD
0.0102 Tc
-0.0695 Tw
(krwawienia, ktre wystpiy w okresie obserwacji, nie)Tj
0 -1.4433 TD
0.017 Tc
0.0852 Tw
(wymagay przerwania leczenia przeciwzakrzepowe-)Tj
T*
0.0176 Tc
0.0913 Tw
(go. W innym badaniu obserwacj objto 70 pacjen-)Tj
0 -1.4467 TD
-0.0018 Tw
[(tw z APS,)14.6( przyjmujcych warfaryn [6]. Znamienne)]TJ
0 -1.4433 TD
0.0183 Tc
0.1389 Tw
(zmniejszenie odsetka nawrotw zakrzepicy stwier-)Tj
T*
0.0181 Tc
0.0159 Tw
(dzono u osb, u ktrych INR utrzymywano w grani-)Tj
0 -1.4467 TD
0.0178 Tc
-0.0276 Tw
[(cach 2,0)16.8(2,9 oraz )]TJ
/F6 1 Tf
8.33 0 TD
0 Tc
0 Tw
()Tj
/F2 1 Tf
0.85 0 TD
0.018 Tc
-0.0291 Tw
[( 3,0, natomiast mniej intensywna)]TJ
-9.18 -1.4433 TD
0.0172 Tc
-0.0195 Tw
(antykoagulacja \(INR )Tj
/F6 1 Tf
9.3633 0 TD
0 Tc
0 Tw
()Tj
/F2 1 Tf
0.85 0 TD
0.0172 Tc
-0.0195 Tw
[( 1,9\) nie zabezpieczaa pacjen-)]TJ
-10.2133 -1.4433 TD
0.0175 Tc
0.0922 Tw
(tw przed kolejnymi epizodami zakrzepowymi. Ka-)Tj
0 -1.4467 TD
0.0678 Tw
(mashta i wsp. [3] zalecali u chorych z APS i zakrze-)Tj
0 -1.4433 TD
0.0179 Tc
0.077 Tw
(pic utrzymywanie INR na poziomie 3,0 lub wicej.)Tj
T*
0.0174 Tc
0.025 Tw
(Naley jednak podkreli, e u 7 spord 64 pacjen-)Tj
0 -1.4467 TD
0.0225 Tc
0.1389 Tw
(tw leczonych intensywnie warfaryn \(INR > 3,0\))Tj
0 -1.4433 TD
0.0031 Tc
-0.0695 Tw
(wystpiy powane powikania krwotoczne. Natomiast)Tj
T*
0.0175 Tc
-0.0692 Tw
(Ginsberg i wsp. [15] oraz Rance i wsp. [5] sugerowali,)Tj
0 -1.4467 TD
0.0177 Tc
0.0278 Tw
[(e utrzymywanie INR w przedziale 2,0)16.7(3,0 skutecz-)]TJ
0 -1.4433 TD
0.0172 Tc
0.1268 Tw
(nie zabezpiecza pacjentw z APS przed nawrotami)Tj
T*
0.0176 Tc
0.0055 Tw
(epizodw ylnej choroby zakrzepowo-zatorowej.)Tj
1.5733 -1.4467 TD
0.0098 Tc
0.0278 Tw
(W niniejszym badaniu 21 chorych z APS przyjmu-)Tj
-1.5733 -1.4433 TD
0.0235 Tc
0.2055 Tw
[(jcych acenokumarol \(INR 2,0)5.8(3,0\) obserwowano)]TJ
T*
0.0098 Tc
-0.0654 Tw
[(przez 3)8.8(8 lat \(czny okres profilaktyki wynis 95 lat\).)]TJ
0 -1.4467 TD
0.007 Tc
-0.0694 Tw
(Oznaczenia czasu protrombinowego wykonywano nie)Tj
0 -1.4433 TD
0.0097 Tc
-0.0618 Tw
[(rzadziej ni co 4 tygodnie, a warto INR utrzymywaa)]TJ
T*
0.0095 Tc
-0.0389 Tw
[(si w przedziale 2,0)8.5(3,0 przez 70% czasu obserwacji.)]TJ
0 -1.4467 TD
0.1287 Tw
(Podczas obserwacji stwierdzono tylko 1 nawrt za-)Tj
0 -1.4433 TD
-0.0083 Tw
(krzepicy u pacjenta, ktry samowolnie przesta przyj-)Tj
T*
0.0096 Tc
-0.0657 Tw
(mowa acenokumarol na 3 tygodnie przed nawrotem.)Tj
0 -1.4467 TD
0.0102 Tc
-0.069 Tw
[(Po ponownym wdroeniu O)10.2(A)0.3( \(INR 2,0)9.2(3,0\) nie )]TJ
21.4667 0 TD
-0.0023 Tc
0 Tw
(nast-)Tj
-21.4667 -1.4433 TD
0.0041 Tc
-0.0554 Tw
[(piy)4.1( u )]TJ
2.5658 0 TD
0.009 Tc
-0.0609 Tw
[(niego)-4.3( )8.4(kolejne)10.9( )9.2(epizody zakrzepicy. W okresie ob-)]TJ
-2.5658 -1.4433 TD
0.0236 Tc
0.1933 Tw
(serwacji wystpiy jedynie 3 niewielkie powikania)Tj
0 -1.4467 TD
0.0076 Tc
-0.0666 Tw
[(krwotoczne \(krwawienie z nosa\) )8(niewymaga)]TJ
19.7733 0 TD
-0.0067 Tc
0 Tw
[(jce)-6.7( )]TJ
1.9214 0 TD
0.0066 Tc
(prze-)Tj
-21.6948 -1.4433 TD
0.0092 Tc
-0.068 Tw
(rwania leczenia przeciwzakrzepowego ani hospitaliza-)Tj
T*
0.01 Tc
-0.0055 Tw
(cji chorych.)Tj
1.5733 -1.4467 TD
-0.0004 Tc
-0.0018 Tw
(U 10 pacjentw z APS leczonych acenokumarolem)Tj
-1.5733 -1.4433 TD
-0.0008 Tc
0.1 Tw
(w dawce zapewniajcej utrzymanie INR w przedziale)Tj
T*
-0.0015 Tc
-0.069 Tw
(2,03,0 w cigu 16 tygodni 4-krotnie oznaczono zawar-)Tj
0 -1.4467 TD
-0.0005 Tc
-0.0049 Tw
(to F1+2 w osoczu, ktry zawsze zawiera si w gra-)Tj
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[(2.)-267(Polish rabbit brain thromboplastin reagent \(Biomed,)]TJ
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(Haemat Pol, 33 \(suppl. 1\): 4352.)Tj
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0.0125 Tw
[(2.)-356.9(Musia J \(2002\) Zesp antyfosfolipidowy. In: opaciuk S.)]TJ
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(\(ed.\) Zakrzepy i zatory. PZWL, Warszawa, 89104.)Tj
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[(3.)-357.1(Khamashta MA, Guadrado MJ, Mujic F, Taub NA, Hunt)]TJ
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(BJ, Hughes GRV \(1995\) The management of thrombosis)Tj
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(in the antiphospholipid-antibody syndrome. N Engl J Med,)Tj
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(332: 993997.)Tj
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[(4.)-356.9(Prandoni P, Simioni P, Girolami A \(1996\) Antiphospholip-)]TJ
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(id antibodies, recurrent thromboembolism, and intensity)Tj
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[(5.)-356.8(Rance A, Emmerich J, Fiessinger J-N \(1997\) Anticardio-)]TJ
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(Haemost, 77: 221222.)Tj
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(bosis: clinical course after the first thrombotic event in 70)Tj
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(patients. Ann Intern Med, 117: 303308.)Tj
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0.1 Tw
[(7.)-356.7(Moll S, Ortel TL \(1997\) Monitoring warfarin therapy in)]TJ
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[(8.)-356.9(Wilson WA, Gharavi AE, Koike T, Lockshin MD, Branch)]TJ
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(for definite antiphospholipid syndrome. Report of an In-)Tj
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(ternational Workshop. Arthritis Rheum, 42: 13091311.)Tj
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[(9)-13.9(.)-369.6(Bertina RM, Koelman BPC, Koster T, Rosendaal FR, Dirven)]TJ
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[(RJ, de Ronde H, van der Velden PA, Reitsma PH \(1994\))]TJ
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(Mutation in blood coagulation factor V associated with)Tj
T*
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(resistance to activated protein C. Nature, 369: 6467.)Tj
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[(10.)-739.5(Poort SR, Rosendaal FR, Reitsma PH, Bertina RM \(1996\))]TJ
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[(1)42.3(1)42.3(.)-696.1(Robert A, Le Querrec A, Delahousse B, Caron C,)]TJ
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[(1)-14.3(4)-14.3(.)-752.7(Windyga J \(2002\) Przeciwciaa antyfosfolipidowe jako czyn-)]TJ
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[(15.)-739.3(Ginsberg JS, Wells PS, Brill-Edwards P, Donovan D, Mof-)]TJ
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[(1028)24(1)5.6(0)5.5(3)5.6(2)5.5(.)]TJ
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